CELL BIOLOGY OF SIGNALING ACROSS MEMBRANES

跨膜信号传导的细胞生物学

• 批准号: 8359564
• 负责人: CHRISTOPHER S VON BARTHELD
• 金额: $ 214.23万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359564
• 关键词: Achievement; Apoptosis; Area; Biological Models; Biomedical Research; Cell membrane; Cell physiology; Cells; Cellular biology; Centers of Research Excellence; Clinical; Disease; Endocytosis; Enteral; Faculty; Fostering; Funding; Gene Expression Regulation; Generations; Goals; Grant; Growth Factor; Human; Immune System Diseases; Lead; Malignant Neoplasms; Medicine; Membrane; Membrane Protein Traffic; Mentors; Molecular; Molecular Genetics; National Center for Research Resources; Neurodegenerative Disorders; Nevada; Nuclear; Principal Investigator; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Science; Signal Transduction; Source; Training Programs; United States National Institutes of Health; Universities; axon guidance; college; computerized data processing; cost; interdisciplinary approach; malformation; nervous system disorder; programs; public health relevance; synergism; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases. Signal transduction and molecular trafficking are intertwined in ways that make it impossible to truly understand mechanisms of either in isolation. We propose to create a Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR) in the area of cell biology of signaling across membranes. This COBRE will make significant progress in the emerging fusion of the fields of membrane trafficking and signal transduction by examining how molecular signaling is achieved across membranes, both between cells and between subcellular compartments. Five junior faculty with outstanding research accomplishments will use diverse and uniquely advantageous model systems where critical aspects of signaling and transport functions can be examined by molecular, genetic and structural approaches. The proposed research topics will utilize interdisciplinary approaches in the field of signal transduction and molecular trafficking, including growth factor signaling, regulation of gene expression, nuclear and cytoplasmic transport, secretion, endocytosis, apoptosis, and axon guidance. The proposed COBRE is a comprehensive effort that will integrate high-quality biomedical research and expertise in different departments and colleges at UNR under one theme and program. This will bridge the traditional physical and administrative division between the Colleges of Science and Medicine on the upper and lower campus at UNR, and foster interactions that lead to synergism and enhanced biomedical research capacity. The COBRE will provide an efficient mentoring program for junior faculty that will expand already existing training programs at UNR, and support the research of selected young faculty by teaming with clinical mentors and consultants to establish disease focus. The COBRE will provide enhanced infrastructure and technical support for Nevada's new generation of biomedical researchers with truly outstanding credentials and promise for major achievements in biomedical research. PUBLIC HEALTH RELEVANCE (provided by applicant): Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases, ranging from cancer (abnormal proliferation) to neurodegenerative diseases (abnormal trophic signaling). The common and ultimate overall research goal of this proposal is to understand, and eventually manipulate, fundamental processes of signaling in cell biology that are relevant for human disorders, including cancer, immunological and neurological diseases and enteric malformations.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 描述（由申请人提供）：跨细胞膜的信号对于正常细胞功能和理解许多疾病至关重要。信号转导和分子运输的交织方式使人们无法真正理解任何一个孤立的机制。我们建议在内华达大学里诺（UNR）的内华达大学（UNR）建立一个生物医学研究卓越中心（COBRE），跨膜信号传导领域。该毛刺将通过检查如何在细胞之间和亚细胞隔室之间的膜之间进行分子信号传导，从而在膜运输和信号转导的领域的新出现融合和信号转导。具有出色研究成就的五个初级教师将使用各种和独特的有利模型系统，在这些模型系统中，可以通过分子，遗传和结构方法来检查信号和运输功能的关键方面。拟议的研究主题将利用信号转导和分子运输领域的跨学科方法，包括生长因子信号传导，基因表达的调节，核和细胞质转运，分泌，内吞作用，凋亡，凋亡和轴突指导。拟议中的鞋垫是一项全面的努力，它将在一个主题和计划下在UNR的不同部门和大学中整合高质量的生物医学研究和专业知识。这将弥合UNR上上下校园的科学与医学学院的传统物理和行政划分，并促进导致协同作用并增强生物医学研究能力的相互作用。该柯布尔将为初级教师提供有效的指导计划，该计划将在UNR扩大现有的培训计划，并通过与临床导师和顾问合作以建立疾病的重点来支持所选年轻教师的研究。该鞋底将为内华达州的新一代生物医学研究人员提供增强的基础设施和技术支持，并具有真正出色的证书和对生物医学研究的重大成就的希望。 公共卫生相关性（由申请人提供）：跨细胞膜的信号对于正常的细胞功能和了解许多疾病至关重要，从癌症（异常增殖）到神经退行性疾病（异常营养信号）。该提案的共同和最终的总体研究目标是了解并最终操纵与人类疾病有关的细胞生物学信号传导的基本过程，包括癌症，免疫学和神经系统疾病以及肠道畸形。