Structure of Semantic Memory and its Measurement in Dementia and Aphasia

痴呆和失语症的语义记忆结构及其测量

• 批准号: 8117577
• 负责人: James Joseph Reilly
• 金额: $ 17.33万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-10 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8117577
• 关键词: Alzheimer' s Disease; Aphasia; Award; Brain; Clinic; Clinical; Clinical Research; Cognition; Communities; Data Analyses; Dementia; Deterioration; Development Plans; Diagnostic; Differential Diagnosis; Doctor of Medicine; Doctor of Philosophy; Electroencephalography; Environmental Wind; Florida; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Hospitals; Impairment; Institutes; Knowledge; Language; Measurement; Measures; Medical; Medical center; Memory Disorders; Mentors; Neuropsychology; Patients; Public Health; Recruitment Activity; Rehabilitation Research; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Semantic memory; Semantics; Specificity; Staging; Structure; Techniques; Testing; Universities; Variant; Veterans; abstracting; aging population; career development; cognitive neuroscience; improved; loris; neurobehavioral; neurophysiology; rapid growth; relating to nervous system; skills; theories; trauma centers

DESCRIPTION (provided by applicant): During the project period we will investigate the structure and deterioration of semantic memory (i.e., stored knowledge of word and object meaning) and develop an assessment of verbal and nonverbal semantic memory that can be used to stage impairment in dementia. The trainee's long-term goal is to develop and sustain this programmatic line of research as an independent investigator. The K-23 mentored award will foster this goal through a career development plan that emphasizes the following objectives: 1)To advance the trainee's knowledge of neurophysiological and neurobehavioral measurement techniques (e.g., electroencephalography, fMRI); 2) To improve the trainee's knowledge of clinical research design and data analysis; and 3) To improve the trainee's skill in obtaining competitive research funding. The trainee will conduct the bulk of his research at the University of Florida, a major research university whose onsite resources include the McKnight Brain Institute (equipped with 3 Tesla Philips MR Scanner), Shands Hospital (level I trauma center with satellite memory disorders clinics for patient recruiting) and the Brain Rehabilitation Research Center (BRRC) of the Malcom Randall Veterans Affairs Medical Center. In addition to substantial research infrastructure, UF offers an outstanding intellectual community with renowned researchers in cognitive neuroscience and clinical neuropsychology. Primary mentors for the K-23 include Bruce Crosson, Ph.D. and Leslie Gonzalez-Rothi, Ph.D. Additional contributors include Murray Grossman, M.D., Edith Kaan, Ph.D., Wind Cowles, Ph.D., Nadine Martin, Ph.D., and Lori Altmann, Ph.D. Specific aims are as follows: 1) We will assess the neural substrates of concept representation using both spatially sensitive (i.e., fMRI) and temporally sensitive (i.e, ERP) measures in support of a biologically-constrained theory of semantic cognition; 2) We will develop a psychometrically valid measure of semantic memory with test-retest reliability that can be used to stage the intergrity of multiple components of semantic memory in dementia. Components of this battery will include knowledge: a) word meaning; b) perceptual features; c) abstract attributes; d) environmental context; e) associative relationships; and f) object function. RELEVANCE: The rapid growth of dementia in our aging population poses a clear public health crisis; differential diagnosis among the many dementia variants is crucial for effective medical management. Profiles of language and semantic memory can potentially provide diagnostic markers for distinguishing Alzheimer's disease from other dementias. However, lack of specificity inherent within existing scales limits their clinical utility.

描述（由申请人提供）：在项目期间，我们将研究语义记忆的结构和恶化（即存储了对单词和对象含义的知识），并对可以用来在痴呆症中进行障碍的口头和非语言语义记忆进行评估。学员的长期目标是作为独立研究者发展和维持这一程序化研究线。 K-23指导奖将通过强调以下目标的职业发展计划来促进这一目标：1）促进受训者对神经生理学和神经行为测量技术的了解（例如，脑电图，fMRI）； 2）提高学员的临床研究设计和数据分析知识； 3）为了提高学员获得竞争性研究资金的技巧。 The trainee will conduct the bulk of his research at the University of Florida, a major research university whose onsite resources include the McKnight Brain Institute (equipped with 3 Tesla Philips MR Scanner), Shands Hospital (level I trauma center with satellite memory disorders clinics for patient recruiting) and the Brain Rehabilitation Research Center (BRRC) of the Malcom Randall Veterans Affairs Medical Center.除了实质性的研究基础设施外，UF还通过认知神经科学和临床神经心理学领域的著名研究人员提供了一个杰出的知识社区。 K-23的主要导师包括Bruce Crosson博士。和Leslie Gonzalez-Rothi博士其他贡献者包括医学博士Murray Grossman，Edith Kaan，Ph.D.，Wind Cowles，Ph.D.具体目的如下：1）我们将使用空间敏感的（即fMRI）和时间敏感（即ERP）测量来评估概念表示的神经底物，以支持对生物学约束的语义认知理论； 2）我们将使用重新测试可靠性来开发一种对语义记忆的有效度量，可用于分阶段进行痴呆症语义记忆的多个组成部分的整个组成部分。该电池的组件将包括知识：a）单词含义； b）感知特征； c）抽象属性； d）环境环境； e）关联关系；和f）对象功能。 相关性：痴呆症在我们老龄化的人口中的快速增长构成了明显的公共卫生危机；许多痴呆症变体之间的鉴别诊断对于有效的医疗管理至关重要。语言和语义记忆的概况可能会提供诊断标记，以区分阿尔茨海默氏病和其他痴呆症。但是，现有量表内固有的缺乏特异性限制了其临床实用性。