Animal Imaging

动物成像

• 批准号: 8104198
• 负责人: Bradford Moffat
• 金额: $ 64.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-05 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8104198
• 关键词: Animals; Arts; Biological Markers; Biological Sciences; Bioluminescence; Cell Line; Clinical; Clinical Trials; Custom; Data; Data Collection; Devices; Educational workshop; Health; Housing; Human Resources; Image; Imaging technology; Interdisciplinary Study; Laboratories; Lead; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Maps; Michigan; Microscope; Modeling; Molecular Biology; Mus; Optics; Patients; Perfusion; Postdoctoral Fellow; Preparation; Production; Protocols documentation; Protons; Rattus; Recombinant Proteins; Recombinants; Recruitment Activity; Research; Research Personnel; Resource Sharing; Resources; Scanning; Schedule; Science; Security; Services; Spectrum Analysis; Spin Labels; System; Time; Training; Universities; Weight; anticancer research; computerized data processing; data acquisition; design; digital imaging; experience; image processing; image reconstruction; in vivo; innovation; investigator training; lectures; medical schools; molecular imaging; operation; programs; research study; success; technique development; treatment response; tumor; water diffusion

CORE B: Animal Imaging Core. The Animal Imaging Core will perform all MRI/S and bioluminescence studies on mouse tumor models for Projects 1 and 2. Core personnel will provide these services: (a) define and implement data acquisition/imaging sequences; (b) assist with animal preparation for imaging; (c) perform all data collection on the 9.4 Tesla MRI, 7 Tesla MRI and Xenogen bioluminescence systems; (d) preliminary data processing/image reconstruction; (e) security archival of raw data and network transfer of reconstructed data to the Digital Image Processing Core (Core C); (f) scheduling of imaging experiments; and (g) provide support to Program Investigators in technical design of imaging experiments. These services designed, in part, after a "clinical MRI service" model since continual, high-volume animal scanning is essential for success of each project. More then 8000 sessions of MRI/S and 7000 bioluminescence scans will be performed over five years. Specific animal MRI/S protocols will vary with each project, but will primarily include serial studies using: standard T2-weighted; T1-weighted dynamic contrast enhanced; multislice quantitative water diffusion mapping; arterial spin labeling perfusion mapping; single-voxel proton spectroscopy. Dr. B.A. Moffat will serve as Core B Director. Dr. Moffat has extensive experience in small animal imaging research. A Co-Investigator and a Post-Doc will assist Dr. Moffat with day-to-day operations and technique development. A full time MR research technician will perform the remainder of Core B services.

核心B：动物成像核心。动物成像芯将执行所有MRI/S和生物发光 项目1和2的小鼠肿瘤模型的研究。核心人员将提供以下服务：（a）定义 并实施数据采集/成像序列； （b）协助动物制备成像； （C） 在9.4 Tesla MRI，7 Tesla MRI和异种生物发光系统上执行所有数据收集； （D） 初步数据处理/图像重建； （e）原始数据和网络传输的安全档案 重建数据到数字图像处理核心（核心C）； （f）成像实验的调度； （g）在成像实验的技术设计方面为计划调查人员提供支持。这些 由于连续的，大量的动物扫描，因此在某种程度上设计的服务部分是在“临床MRI服务”模型之后设计的 对于每个项目的成功至关重要。超过8000次MRI/S和7000次生物发光 扫描将在五年内进行。特定的动物MRI/S协议将随着每个项目的变化，但是 主要包括以下串行研究：标准T2加权； T1加权动态对比增强了； 多层定量水扩散映射；动脉自旋标记灌注映射；单素质子 光谱法。博士莫法特将担任B核心主管。莫法特博士在小的经验中有丰富的经验 动物成像研究。共同投资者和演出后将协助莫法特博士进行日常操作 和技术开发。全日制MR研究技术员将执行其余的核心B 服务。