STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL

评估毒理学和致癌潜力的研究

• 批准号: 8328335
• 负责人: CHARLES HERBERT
• 金额: $ 19.41万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-10-30 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8328335
• 关键词: Chemicals; Chemistry; Chronic; Contracts; Cutaneous Administration; Flame Retardants; Indole-3-Carbinol; Ketones; Laboratory Animals; Mus; Oxides; Perinatal; Rattus; Toxic effect; Wistar Rats; carcinogenicity; design; programs

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This contract involes the prechronic and chronic studies of 5 chemicals by gavage and dermal routes including Pentabromodiphenyl oxide (DE-71); Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate. The 90-Day studies of Pentaerythritol triacrylate, Pentabromodiphenyl oxide and Indole-3-carbinol have been completed and reported. The 2-year studies for Pentaerythritol triacrylate and Indole-3 carbinol have been cancelled from this contract. The in-life portion of the 2-year Methyl styryl ketone and Trimethylolpropane triacrylate studies have been completed. Chronic 2 year studies on Pentabromodiphenyl oxide are ongoing in rats and mice. In the Pentabromodiphenyl oxide chronic rat study, rats have been treated in utero beginning on gestation day 6, continuing through the lactation period and will be continuously treated through puberty to adulthood. Dosing will continue until rats are two years of age at which time animals will be thoroughly examined for signs of carcinogenicity. Keywords Carcinogenicty; Toxicity; Wistar Han rats; Fisher rats; B6C3F1 mice; perinatal; triacrylates, flame retardants; Pentabromodiphenyl oxide; DE-71; Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate.

该合同的目的是提供国家毒理学计划（NTP）危害识别活动的支持，该活动针对预防疾病或由环境暴露于化学或物理药物引起的不良影响。该合同涉及对5种化学物质和皮肤途径的5种化学物质进行的预测和慢性研究，包括五苯基二苯基氧化物（DE-71）；吲哚-3-甲醇;甲基styryl酮；五烷基三烯酸酯；和三甲基丙烷三晶。对五烷基三烯酸戊酸酯，戊二苯基氧化物和吲哚-3-甲醇的90天研究已完成并报告。该合同中取消了针对三烯酸五戊酯和吲哚-3卡比醇的两年研究。两年甲基苯乙烯酮和三甲基丙烷三晶酸酯研究的生命部分已经完成。在大鼠和小鼠中，对五苯基氧化苯基苯基的慢性2年研究正在进行中。在五苯基二苯基氧化物慢性大鼠研究中，在妊娠第6天开始在子宫内治疗大鼠，一直持续到整个泌乳期，并将通过青春期到成年后不断治疗。剂量将继续持续到大鼠两岁的时候，在此期间将彻底检查动物是否有致癌性的迹象。 关键词癌变；毒性; Wistar Han Rats；费舍尔大鼠； B6C3F1小鼠；围产期三角晶，阻燃剂；戊二苯基氧化物； DE-71;吲哚-3-甲醇;甲基styryl酮；五烷基三烯酸酯；和三甲基丙烷三晶。