Simian Vaccine Evaluation Unit (SVEU)

猿猴疫苗评估中心 (SVEU)

• 批准号: 8328469
• 负责人: Phillip D Markham
• 金额: $ 461.02万
• 依托单位: ADVANCED BIOSCIENCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-22 至 2012-06-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8328469
• 关键词: AIDS Vaccines; Advanced Development; Animals; Antibodies; Biological Assay; Caring; Cercocebus atys; Cercopithecine Herpesvirus 1; Cercopithecus pygerythrus; Chinese People; Contracts; Data; Databases; Development; Family suidae; Housing; Immunologics; Immunotherapy; In Vitro; Infection; Laboratories; Macaca; Macaca fascicularis; Macaca mulatta; Macaca nemestrina; Maintenance; Modality; National Institute of Allergy and Infectious Disease; Papio; Prevention; Protocols documentation; Records; Retroviridae; SIV; Tail; Testing; Tuberculosis; Type D Retrovirus; Virus; microbicide; nonhuman primate; protocol development; simian T cell lymphotrophic virus; vaccine evaluation

The major functions to be carried out by the Simian Vaccine Evaluation Units (SVEUs) are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-tail macaques (Macaca nemestrina), cynomolgus monkeys (Macaca fascicularis), African green monkeys (Cercocebus atys), or baboons may be requested. 2. Housing and care of non-human primates; maintenance of animal records (Provide tuberculosis (TB)-free nonhuman primates that are also free of infection with simian immunodeficiency virus (SIV), simian T-cell lymphotrophic virus (STLV), and simian type D retrovirus (SRV). To confirm that animals are free from infection with these retroviruses, conduct testing of the nonhuman primates to screen for these viruses prior to purchase and shipment to the SVEU facility. In addition, test the nonhuman primates for the presence of antibodies to simian herpes B virus so that their serostatus is known. 3. Protocol Development 4. Conduct of Studies 5. In Vitro Laboratory Immunologic and Virologic Assays 6. Storage and shipment of materials 7. Entry of SVEU study protocols, information, and data into the DAIDS SVEU database

猿猴疫苗评估单位（SVEU）的主要职能如下： 1 非人灵长类动物的采集和测试（重点关注印度猕猴（Macaca mulatta）、中国猕猴或其他非人灵长类动物，如猪尾猕猴（Macaca nemestrina）、食蟹猴（Macaca nemestrina）食蟹猴）、非洲绿猴（Cercocebus atys）或狒狒可能会被要求。 2. 非人类灵长类动物的饲养和护理；维护动物记录（提供无结核病（TB）且未感染猿猴免疫缺陷病毒（SIV）、猿猴T细胞淋巴病毒（STLV）和猿猴D型逆转录病毒（SRV）的非人灵长类动物。以确认如果动物没有感染这些逆转录病毒，则在购买并运送到 SVEU 设施之前对非人类灵长类动物进行测试以筛查这些病毒。非人灵长类动物是否存在猿猴疱疹 B 病毒抗体，以便了解其血清状态。 3. 协议开发 4. 研究的进行 5. 体外实验室免疫学和病毒学测定 六、材料的储存和运输 7. 将 SVEU 研究方案、信息和数据输入 DAIDS SVEU 数据库