Sensory Over Responsivity & Anxiety in Youth with Autism

感觉过度反应

• 批准号: 8255104
• 负责人: Shulamite Abra Green
• 金额: $ 3.33万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-11-16 至 2014-11-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8255104
• 关键词: Accounting; Adaptive Behaviors; Affect; Aftercare; Amygdaloid structure; Anxiety; Anxiety Disorders; Area; Autistic Disorder; Basic Science; Brain; Brain Mapping; Child; Clinical; Cognitive Therapy; Combined Modality Therapy; Development; Diagnosis; Discipline; Enrollment; Event; Exhibits; Functional disorder; Goals; Health Benefit; Hippocampus (Brain); Image; Impairment; Intervention; Interview; Link; Nature; Neurologic; Occupational Therapy; Participant; Provider; Psychiatry; Psychology; Public Health; Recruitment Activity; Research; Sensory; Severities; Social Functioning; Strategic Planning; Structure; Symptoms; Syndrome; Testing; Wood material; Work; Youth; aged; auditory stimulus; autism spectrum disorder; base; biobehavior; cost effective; disease classification; high risk; improved; relating to nervous system; response; sensory stimulus; therapy design; visual stimulus

Youth with autism spectrum disorders (ASD) are at high risk for anxiety and sensory over-responsivity (SOR), which cause significant impairments in adaptive behavior and social functioning independent of ASD severity. While emerging research shows an association between these two syndromes in children with ASD, little is known about (1) the mechanism that links them, such as a common neurological basis, and (2) implications of this association for the treatment of children with ASD. It is possible that anxiety and SOR have a similar neural basis, such as amygdala and hippocampus abnormalities, but the brain structure and function of children with ASD and SOR has not been examined. Findings of a similar neural basis might support a coordinated diagnosis and treatment approach for anxiety and SOR in youth with autism. The proposed study takes a two- pronged approach to improve the understanding and treatment of these two syndromes: the first is a basic science approach to identifying putative common neural abnormalities underlying anxiety and SOR, and the second is a treatment design to examine whether the connection between anxiety and SOR has real-world implications for intervention. Participants will be 68 children with ASD, aged 10-14 years, recruited from the UCLA Center for Autism Research and Treatment (CART) into ongoing imaging studies at the UCLA Brain Mapping Center. Children who are above the cutoff for significant anxiety on a standardized anxiety interview (approximately 38) will be enrolled in an ongoing cognitive-behavioral treatment (CBT) intervention for youth with ASD and comorbid anxiety disorders. The proposed study will examine amygdala and hippocampus volume as well as brain response to mildly unpleasant sensory stimuli in relation to symptoms of SOR and anxiety. Additionally, this study will test whether symptoms of SOR improve over the course of CBT for children with ASD and anxiety, and whether improvements in SOR correspond with improvements in anxiety. This work will contribute to the field by facilitating understanding of the nature and impact of anxiety and SOR in autism, with possible implications for the development of a more effective and efficient treatment approach for these two related syndromes. These aims are consistent with the aspirational goals of the 2009 Interagency Autism Coordinating Committee Strategic Plan for Autism Spectrum Disorder Research, which stipulates the need for biobehavioral studies of ASD to identify and characterize co-occurring symptoms.

自闭症谱系障碍（ASD）的青年处于焦虑和感觉过度响应率（SOR）的高风险，这些风险与ASD严重程度无关，在适应性行为和社会功能方面造成了重大损害。虽然新兴研究表明，ASD儿童的这两种综合症之间存在关联，但对（1）将它们联系起来的机制，例如共同的神经系统基础，以及（2）这种关联对治疗ASD儿童的影响。焦虑和SOR可能具有相似的神经基础，例如杏仁核和海马异常，但是尚未检查ASD和SOR儿童的大脑结构和功能。相似的神经基础的发现可能支持自闭症青年的焦虑和SOR的协调诊断和治疗方法。拟议的研究采用了两种措施的方法来改善对这两种综合症的理解和治疗：第一种是一种基础科学方法，用于识别焦虑和SOR的假定常见神经异常，第二个是一种治疗设计，用于检查焦虑与SOR之间的联系是否具有现实的干预效果。参与者将是68名ASD儿童，年龄10-14岁，从UCLA自闭症研究与治疗中心（CART）招募到UCLA脑映射中心正在进行的成像研究。在标准化焦虑访谈中严重焦虑（约38个）的儿童将纳入正在进行的认知行为治疗（CBT）干预措施（CBT）干预措施（CBT），患有ASD和合并症焦虑症。拟议的研究将检查杏仁核和海马体积以及大脑对与SOR和焦虑症状有关的轻度不愉快感觉刺激的反应。此外，这项研究将测试SOR的症状在CBT过程中的ASD和焦虑症患者的CBT过程中是否会改善，以及SOR的改善是否与焦虑症的改善相对应。这项工作将通过促进自闭症中焦虑和SOR在自闭症中的性质和影响的理解来促进该领域，这可能对这两种相关综合症的更有效，更有效的治疗方法产生影响。这些目标与2009年机构间自闭症协调委员会自闭症谱系障碍研究战略计划的理想目标一致，该计划规定了对ASD的生物行为研究的需求，以识别和表征同时发生的症状。