An Open Source Digital Pathology System Supporting Multi-Touch Interaction

支持多点触控交互的开源数字病理系统

• 批准号: 8199429
• 负责人: Beverly Elizabeth Faulkner-Jones
• 金额: $ 14.94万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199429
• 关键词: Accreditation; Address; Anatomy; Architecture; Area; Atlases; Biopsy; Client; Clinical; Collaborations; Collection; Communities; Computer software; Computer-Assisted Diagnosis; Computers; Data; Data Set; Development; Devices; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Environment; Excision; Formalin; Glass; Goals; Health Care Costs; Hematoxylin and Eosin Staining Method; Histologic; Hospitals; Image; Image Analysis; Imagery; Individual; Information Systems; Instruction; Internet; Length; Lesion; Linux; Longevity; Manufacturer Name; Measurement; Medical; Medical Records; Metadata; Microscope; Paraffin; Pathologist; Pathology; Patient Care; Performance; Phase; Plug-in; Process; Radiology Specialty; Reading; Recording of previous events; Research; Resolution; Scanning; Site; Slide; Solutions; Specimen; Speed; Staging; Staining method; Stains; Stream; Supercomputing; Support System; Surgical Pathology; System; Technology; Three-dimensional analysis; Tissues; Touch sensation; Training and Education; Ursidae Family; Waxes; Work; base; computerized tools; cost; cost effective; data integration; design; digital; digital imaging; experience; flexibility; image processing; improved; innovation; insight; interest; medical schools; medical specialties; open source; preference; prototype; segmentation Image analysis; tool

DESCRIPTION (provided by applicant): Medical records are being digitized in order to improve patient care, and the integrated digitization of all components of the medical record will also help reduce the number of errors and reduce health care costs. Images form part of the medical record. In some specialty areas such as radiology, the use of digital imaging is widespread. However, in other specialties digital images are less frequently used. One example is anatomic (surgical) pathology in which a microscope is used to view tissue mounted on a glass slide to obtain an image, a practice that has not changed much over decades. Pathologists have been slow to transition from glass slides to digital imaging for reasons which relate to image acquisition and interpretation. High-resolution digital images are necessary for accurate diagnosis, and acquisition of these images has been slow and expensive. Advances in computer technology have increased the speed of acquisition and reduced costs such that slide digitizing systems are now available from major microscope manufacturers. For digital imaging to become widely accepted in pathology there is still need for innovation to improve performance at all stages of the imaging process including acquisition, user interfaces, display, analysis, access and long-term storage. Here we propose development of a freely available open source system that can operate on multiple different computing platforms (Windows, Mac OSX, Linux) and process slide image data for integration of digital pathology into hospital-wide clinical information systems. The client/server software will manage collection of the image data and create large high resolution images that can be streamed over standard networks for display and remote viewing. Features of the software will include the ability to annotate images as well as support three-dimensional multi-channel datasets. This will enable pathologists to rapidly step through images of successive sections from a tissue block and facilitate three-dimensional analysis of the lesion biopsied. As pathologists require an efficient and fast workflow and may have limited computer expertise, our goal will be to have software that is as fast and easy to use as a microscope- the standard by which pathologists will judge the usefulness of the tool. We will develop and evaluate several client applications, one based on a standard desktop workstation interface paradigm, another deployed within a web browser, and finally a third in a multi-touch environment supporting direct interaction with images. In addition the software will have a plug-in interface (API) that enables development of image processing modules as well as new client interfaces. Ultimately the open source system will have advantages for training, education, remote/collaborative viewing, and research. PUBLIC HEALTH RELEVANCE: Pathology has a storied history in the medical profession and is vital to the diagnosis and treatment of disease. Digital pathology has the potential to advance the efficiency and accuracy of the field, providing new tools for interaction, analysis, collaboration and education.

描述（由申请人提供）：医疗记录正在数字化，以改善患者护理，医疗记录所有组成部分的集成数字化也将有助于减少错误数量并降低医疗保健成本。图像构成医疗记录的一部分。在放射学等一些专业领域，数字成像的使用非常广泛。然而，在其他专业中，数字图像的使用频率较低。一个例子是解剖（外科）病理学，其中使用显微镜观察载玻片上的组织以获得图像，这种做法几十年来没有太大变化。由于与图像采集和解释相关的原因，病理学家从载玻片过渡到数字成像的速度很慢。高分辨率数字图像对于准确诊断是必要的，但获取这些图像的速度缓慢且昂贵。计算机技术的进步提高了采集速度并降低了成本，因此现在主要的显微镜制造商都可以提供载玻片数字化系统。为了使数字成像在病理学中得到广泛接受，仍然需要创新来提高成像过程各个阶段的性能，包括采集、用户界面、显示、分析、访问和长期存储。在这里，我们建议开发一个免费的开源系统，该系统可以在多个不同的计算平台（Windows、Mac OSX、Linux）上运行并处理幻灯片图像数据，以便将数字病理学集成到全医院的临床信息系统中。客户端/服务器软件将管理图像数据的收集并创建大型高分辨率图像，这些图像可以通过标准网络进行流式传输以进行显示和远程查看。该软件的功能包括注释图像以及支持三维多通道数据集的能力。这将使病理学家能够快速浏览组织块的连续切片的图像，并促进对活检病变进行三维分析。由于病理学家需要高效、快速的工作流程，并且计算机专业知识可能有限，因此我们的目标是拥有像显微镜一样快速且易于使用的软件，这是病理学家判断该工具有用性的标准。 我们将开发和评估多个客户端应用程序，一个基于标准桌面工作站界面范例，另一个部署在网络浏览器中，最后一个在支持与图像直接交互的多点触控环境中。此外，该软件还将具有一个插件接口（API），可用于开发图像处理模块以及新的客户端接口。最终，开源系统将在培训、教育、远程/协作查看和研究方面具有优势。 公共卫生相关性：病理学在医学界有着悠久的历史，对于疾病的诊断和治疗至关重要。 数字病理学有潜力提高该领域的效率和准确性，为交互、分析、协作和教育提供新工具。