Microvascular Functional Imaging System
微血管功能成像系统
基本信息
- 批准号:8196672
- 负责人:
- 金额:$ 15.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAgeAlgorithmsAmericanAmputationAreaCardiovascular systemCenter for Translational Science ActivitiesClinicClinicalClinical ResearchClinical SciencesComplicationComputer softwareDataDevicesDiabetes MellitusDiabetic FootDiabetic RetinopathyDiagnosisDiseaseDoctor of PhilosophyEarly DiagnosisEconomicsElderlyEndocrinologyEnvironmentEthanolEye diseasesFoot UlcerFunctional ImagingFunctional disorderHealth SciencesHeart DiseasesHome environmentHypoglycemiaImageImage AnalysisImaging DeviceImaging technologyIndividualInternal MedicineKidney DiseasesLegal patentLower ExtremityMagnetic Resonance ImagingMeasurementMeasuresMedicalMedical ImagingNeuronsNew MexicoNon-Insulin-Dependent Diabetes MellitusPatientsPatternPattern RecognitionPeripheral Nervous System DiseasesPeripheral arterial diseasePhasePilot ProjectsPopulationProtocols documentationPublicationsRecruitment ActivityResearchResearch PersonnelRiskScreening procedureSensitivity and SpecificitySignal TransductionSleepStagingStudentsSystemSystemic diseaseTechniquesTechnologyTestingUniversitiesWorkbasecohortcommercializationcomputer sciencecomputerized data processingcostdiabeticdiabetic patientexperiencefootimage processingindependent component analysisinnovationinstrumentnoveloptical imagingpatient orientedpre-clinicalresponsesuccess
项目摘要
DESCRIPTION (provided by applicant):
VisionQuest Biomedical and the University of New Mexico (UNM) Health Science Center have formed a team to implement and demonstrate a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy. This team will develop and test the Microvascular1Functional Imaging System (MFIS), a device that can be easily adopted for both a clinical environment and a tele-screening setting. Diabetes afflicts an estimated 171 million people worldwide, including more than 24 million Americans. Diabetic patients are at risk for a wide array of complications including heart disease, kidney disease (nephropathy), ocular diseases (diabetic retinopathy), and peripheral neuropathy (diabetic foot). Two million diabetics will develop a foot ulcer during their lifetime. Foot ulcers are the main cause, 85 percent, of lower extremity amputation in patients with diabetes. Our MFIS device is aimed to show that differences in the functional signals will reveal pre- clinical indications of peripheral neuropathy. There are three specific aims to be accomplished in Phase I. The first aim is to integrate, calibrate and test the MFIS device. The second aim is to use the MFIS to conduct a clinical study using subjects to be recruited at the University of New Mexico Endocrinology Clinic. In the third aim we will use advanced signal and image processing techniques, such as Independent Component Analysis (ICA), to extract low-level signals resulting from the functional response captured in thermal and spectral videos. Our commercialization strategy is to create two commercial instruments: One based in thermal imaging that can be used in a clinical setting for diagnosis of peripheral neuropathy, and a second low-cost device based on spectral imaging for screening purposes.
PUBLIC HEALTH RELEVANCE:
Peripheral neuropathy (diabetic foot) is a complication arising from diabetes that causes 82,000 lower extremity amputations in diabetic patients. Fifteen percent of diabetics will undergo amputation sometime in their lives. In this project, we will develop and test the Microvascular Functional Imaging System (MFIS), a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy.
描述(由申请人提供):
VisionQuest Biomedical 和新墨西哥大学 (UNM) 健康科学中心组建了一个团队,实施和演示热光成像系统,用于检测和量化与周围神经病变相关的神经元和微血管功能障碍。该团队将开发和测试微血管功能成像系统(MFIS),这是一种可以轻松应用于临床环境和远程筛查环境的设备。据估计,全世界有 1.71 亿人患有糖尿病,其中包括超过 2400 万美国人。糖尿病患者面临多种并发症的风险,包括心脏病、肾脏疾病(肾病)、眼部疾病(糖尿病视网膜病变)和周围神经病变(糖尿病足)。两百万糖尿病患者一生中会患上足部溃疡。足部溃疡是糖尿病患者下肢截肢的主要原因(85%)。我们的 MFIS 设备旨在表明功能信号的差异将揭示周围神经病变的临床前迹象。第一阶段要实现三个具体目标。第一个目标是集成、校准和测试 MFIS 设备。第二个目标是利用 MFIS 对新墨西哥大学内分泌诊所招募的受试者进行临床研究。在第三个目标中,我们将使用先进的信号和图像处理技术,例如独立分量分析(ICA),来提取从热和光谱视频中捕获的功能响应产生的低电平信号。我们的商业化策略是创建两种商业仪器:一种基于热成像,可在临床环境中用于诊断周围神经病变,另一种基于光谱成像的低成本设备,用于筛查目的。
公共卫生相关性:
周围神经病变(糖尿病足)是糖尿病引起的一种并发症,导致 82,000 名糖尿病患者下肢截肢。百分之十五的糖尿病患者在一生中的某个时候会接受截肢手术。在这个项目中,我们将开发和测试微血管功能成像系统(MFIS),这是一种热光成像系统,用于检测和量化与周围神经病变相关的神经元和微血管功能障碍。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Peter N Soliz', 18)}}的其他基金
Thermal Imaging Modality for Detection of Large and Small Fiber Diabetic Peripheral Neuropathy
用于检测大纤维和小纤维糖尿病周围神经病变的热成像模式
- 批准号:
10601546 - 财政年份:2022
- 资助金额:
$ 15.5万 - 项目类别:
Automated diabetic retinopathy screening system
自动化糖尿病视网膜病变筛查系统
- 批准号:
7792138 - 财政年份:2009
- 资助金额:
$ 15.5万 - 项目类别:
Computer Based Screening for Diabetic Retinopathy
基于计算机的糖尿病视网膜病变筛查
- 批准号:
8855540 - 财政年份:2008
- 资助金额:
$ 15.5万 - 项目类别:
Computer Based Screening for Diabetic Retinopathy
基于计算机的糖尿病视网膜病变筛查
- 批准号:
8502503 - 财政年份:2008
- 资助金额:
$ 15.5万 - 项目类别:
Computer Based Screening for Diabetic Retinopathy
基于计算机的糖尿病视网膜病变筛查
- 批准号:
8312281 - 财政年份:2008
- 资助金额:
$ 15.5万 - 项目类别:
Low-Cost, High Resolution Clinical Retinal Imager
低成本、高分辨率临床视网膜成像仪
- 批准号:
7225774 - 财政年份:2007
- 资助金额:
$ 15.5万 - 项目类别:
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