The East Coast AIDS and Cancer Specimen Resource

东海岸艾滋病和癌症样本资源

• 批准号: 8137105
• 负责人: SYLVIA SILVER
• 金额: $ 137.57万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8137105
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Area; Auras; Cessation of life; Clinical Data; Conflict (Psychology); General Population; Goals; HIV; Highly Active Antiretroviral Therapy; Human body; Immune response; Incidence; Individual; Infection; Leadership; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Manuals; Mission; Morbidity - disease rate; Opportunistic Infections; Pathogenesis; Population; Procedures; Qualifying; Research; Research Personnel; Resources; Role; Smoking; Therapeutic; Translational Research; Virus Diseases; Washington; Work; cancer specimen resource; member; mortality; operation; organizational structure; pandemic disease; repository; theories; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Area; Auras; Cessation of life; Clinical Data; Conflict (Psychology); General Population; Goals; HIV; Highly Active Antiretroviral Therapy; Human body; Immune response; Incidence; Individual; Infection; Leadership; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Manuals; Mission; Morbidity - disease rate; Opportunistic Infections; Pathogenesis; Population; Procedures; Qualifying; Research; Research Personnel; Resources; Role; Smoking; Therapeutic; Translational Research; Virus Diseases; Washington; Work; cancer specimen resource; member; mortality; operation; organizational structure; pandemic disease; repository; theories

DESCRIPTION (provided by applicant): Although infection with the human immunodeficiency virus (HIV) has been widely researched, there is still not yet definitive proof of its pathogenesis in the human body. Conflicting theories exist regarding exact mechanisms in the progression from HIV infection to AIDS. Unfortunately, no one theory has been accepted that definitively explains the ability of HIV to evade our immune response. It is true that scientific research has produced therapeutic products for HIV-infected individuals that can increase their life-spans and reduce the incidence of opportunistic infections, which caused so much morbidity and mortality at the beginning of the pandemic. But despite highly active antiretroviral therapy (HAART), HIV-associated malignancies still cause almost a third of the deaths in HIV disease and research questions abound. For instance, elucidation is needed to explain the recent increase in non-AIDS defining malignancies; why some of these malignancies present with such aggressiveness as compared to the general population; why increases in lung cancer are not explained by the unusually high incidence of smoking present in this population, etc. Clearly, we need to unravel the aura of HIV-associated malignancies. Therefore, having resources available to investigators working in this important area of HIV research is of paramount importance. The National AIDS and Cancer Specimen Resource (ACSR) fills an important role by making available necessary biospecimens and associated clinical data to investigators. The East Coast AIDS and Cancer Specimen Resource (EC ACSR) led by the George Washington University Medical Center (GWUMC), is one of the most active members of the National ACSR. The major goals of the EC ACSR are to 1) support the National ACSR (following the NCI Best Practices for Biospecimen Resources, the ACSR Manual of Operations and the ACSR Standard Operating Procedures) as a productive Regional Biospecimen Repository (RBR) by participating in a significant way to assist investigators in the area of HIV-associated malignancy research, 2) continue as a major team member in the scientific and administrative functions of the ACSR, and 3) facilitate interdisciplinary HIV-related studies and the ACSR.

描述（由申请人提供）：尽管对人类免疫缺陷病毒（HIV）的感染进行了广泛的研究，但仍未证明其在人体中的发病机理。关于从艾滋病毒感染到艾滋病进展的确切机制的理论相互矛盾。不幸的是，没有一个理论被认为可以明确地解释艾滋病毒逃避我们的免疫反应的能力。的确，科学研究已经为感染的艾滋病毒感染者生产了治疗产品，这些人可以增加寿命并减少机会性感染的发生，这在大流行开始时引起了如此多的发病率和死亡率。但是，尽管高度活跃的抗逆转录病毒疗法（HAART），与HIV相关的恶性肿瘤仍然导致艾滋病毒疾病中几乎三分之一的死亡，研究问题比比皆是。例如，需要阐明来解释定义恶性肿瘤的最新提高。为什么与普通人群相比，这些恶性肿瘤中的一些具有侵略性？为什么在该人群中存在的吸烟发生率异常高。显然，我们需要揭示与HIV相关的恶性肿瘤的光环。因此，为在艾滋病毒研究的这一重要领域工作的研究人员提供资源至关重要。 国家艾滋病和癌症标本资源（ACSR）通过使研究人员提供必要的生物测量和相关的临床数据，从而填补了重要的作用。由乔治华盛顿大学医学中心（GWUMC）领导的东海岸艾滋病和癌症标本资源（EC ACSR）是国家ACSR中最活跃的成员之一。 The major goals of the EC ACSR are to 1) support the National ACSR (following the NCI Best Practices for Biospecimen Resources, the ACSR Manual of Operations and the ACSR Standard Operating Procedures) as a productive Regional Biospecimen Repository (RBR) by participating in a significant way to assist investigators in the area of​​ HIV-associated malignancy research, 2) continue as a major team member in the scientific and administrative functions of the ACSR和3）促进跨学科的HIV相关研究和ACSR。