East Coast AIDS and Cancer Specimen Bank

东海岸艾滋病和癌症样本库

• 批准号: 6771132
• 负责人: SYLVIA SILVER
• 金额: $ 97.28万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6771132
• 关键词: AIDS related neoplasm /cancer; cancer registry /resource; clinical research; cooperative study; cryopreservation; human immunodeficiency virus 1; human tissue; information dissemination; information systems; medical outreach /case finding; microarray technology; neoplasm /cancer epidemiology; tissue /cell preparation; tissue resource /registry

DESCRIPTION (provided by applicant): The world has now been confronting the challenges posed by the human immunodeficiency virus (HIV) for more than two decades. Researchers have excelled in elucidating the biology of this virus and establishing targets for therapy. However, individuals infected with this virus show a marked increase in malignancies, which are usually more aggressive and difficult to treat. Translational research is gravely needed on the spectrum of HIV-associated malignancies, e.g., effects of prolonged moderate immunodeficiency, response, incomplete or failed response to antiretroviral therapies; other infectious agents and their interactions with HIV. The major goal of this proposal is to sustain the East Coast AIDS and Cancer Specimen Bank (EC ACSB) as a major resource in the support of translantional research into the pathogenesis of HIV-related malignancies. The specific aims to accomplish this goal are: 1) Establish the EC ACSB membership and organizational structure to continue to support the cooperative efforts of the National AIDS and Cancer Specimen Bank; 2) Expand the inventory of the EC ACSB to dynamically support translational research; 3) Assure quality control of the specimens and data distributed to investigators; 4) Ensure protection of patients' rights while providing specimens and corresponding clinical histories to investigators; and 5) Collaborate with the NCI and other awardees to publicize the National ACSB, establish uniform collection methods and policies, assure quality control of specimens and data, and ensure adequate and proper disbursement of specimens. The George Washington University Medical Center is exceedingly qualified to lead the EC ACSB as exemplified by its past contributions to the National AIDS and Cancer Specimen Bank. The EC ACSB will have tissues and specimens available to investigators reflecting the AIDS pandemic from four continents: North America, South America, Africa and Asia. The EC ACSB will address the special scientific and technical NCI program requirements; and, the Principal Investigator and key personnel have exemplary qualifications and experience which ensures achievement in the implementation, organization and activities of the EC ACSB.

描述（由申请人提供）： 现在，世界一直在面对人类提出的挑战 免疫缺陷病毒（HIV）超过二十年。研究人员有 在阐明该病毒的生物学并建立目标方面表现出色 治疗。但是，感染该病毒的个体显示出明显增加 在恶性肿瘤中，通常更具侵略性和难以治疗。 在艾滋病毒相关的范围内需要进行翻译研究 恶性肿瘤，例如，中度免疫缺陷延长的影响，反应， 对抗逆转录病毒疗法的反应不完全或失败；其他感染力 代理商及其与艾滋病毒的互动。 该提案的主要目标是维持东海岸艾滋病和癌症 标本库（EC ACSB）是支持翻译的主要资源 研究与HIV相关的恶性肿瘤的发病机理。具体目标 实现此目标的是：1）建立EC ACSB成员资格和 组织结构继续支持 国家艾滋病和癌症标本库； 2）扩大EC ACSB的清单 动态支持翻译研究； 3）确保质量控制 分配给研究人员的标本和数据； 4）确保保护 在提供标本和相应临床的同时，患者的权利 调查员的历史； 5）与NCI和其他获奖者合作 宣传国家ACSB，建立统一的收集方法和 政策，确保标本和数据的质量控制，并确保足够 和标本的适当支出。 乔治华盛顿大学医学中心非常有资格 领导EC ACSB以过去对国家艾滋病的贡献为例 和癌症标本库。 EC ACSB将具有组织和标本 可用于反映四大洲艾滋病大流行的研究人员： 北美，南美，非洲和亚洲。 EC ACSB将解决 特殊科学和技术NCI计划的要求；而且，校长 调查员和关键人员具有典范的资格和经验 确保实施，组织和活动的成就 EC ACSB。