ASSESSMENT OF CRH RECEPTOR ANTAGONIST FOR SELF-INJURIOUS BEHAVIOR IN MACAQUES

CRH 受体拮抗剂对猕猴自伤行为的评估

• 批准号: 8357487
• 负责人: Karen Renee Strait
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357487
• 关键词: Alternative Therapies; American; Animal Welfare; Animals; Anti-Anxiety Agents; Behavior; Biomedical Research; Buspirone; CRH gene; Clinical; Corticotropin-Releasing Hormone Receptors; Data; Funding; Grant; Health; Housing; Hydrocortisone; Macaca; Macaca mulatta; Methods; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Process; Research; Research Infrastructure; Resources; Self-Injurious Behavior; Societies; Source; Symptoms; United States National Institutes of Health; base; cost; design; improved; meetings; receptor; research facility

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Self-injurious behavior is one of the most troublesome clinical conditions in rhesus monkeys housed in biomedical research facilities, for which current treatment methods are often ineffective. This study was originally designed to evaluate the efficacy of a CRH1 receptor antagonist in reducing self-injurious behavior (SIB) in captive housed rhesus macaques. During the early part of the study, preliminary data indicated that the CRH1 receptor antagonist consistently increased cortisol levels in monkeys. Based on this unexpected finding, we decided to forgo treatment with the CRH antagonist to avoid exacerbating symptoms and instead focus on alternative therapies. We are currently evaluating treatment for self-injurious and stereotypical behavior with the anxiolytic buspirone. Data has been collected from 8 animals and we are in the process of identifying an additional 2 animals for study. Preliminary results were presented at the American Society of Primatologists 2010 annual meeting. Data from this study has the potential to greatly impact the clinical health of rhesus monkeys both at our center and at other biomedical research facilities, improving animal welfare and allowing for quality research.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 自残行为是生物医学研究设施中恒河猴最麻烦的临床症状之一，目前的治疗方法往往无效。本研究最初旨在评估 CRH1 受体拮抗剂在减少圈养恒河猴自残行为 (SIB) 方面的功效。 在研究的早期阶段，初步数据表明 CRH1 受体拮抗剂持续增加猴子的皮质醇水平。 基于这一意外发现，我们决定放弃 CRH 拮抗剂治疗，以避免症状恶化，转而专注于替代疗法。 我们目前正在评估抗焦虑丁螺环酮对自残和刻板行为的治疗。数据已从 8 只动物身上收集，我们正在确定另外 2 只动物进行研究。 初步结果已在美国灵长类动物学家协会 2010 年年会上公布。 这项研究的数据有可能极大地影响我们中心和其他生物医学研究机构的恒河猴的临床健康，改善动物福利并允许高质量的研究。