GESTATIONAL DIABETES IN RHESUS MONKEYS

恒河猴的妊娠期糖尿病

• 批准号: 8357534
• 负责人: Andrew J. Muir
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357534
• 关键词: Adult; American; Cell Nucleus; Clinical Research; Data; Development; Diabetes Mellitus; Diet; Experimental Animal Model; Fatty acid glycerol esters; Female; Foundations; Funding; Gestational Diabetes; Glucose; Grant; Health; Hyperglycemia; Incidence; Insulin Resistance; Macaca mulatta; Monkeys; National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Pilot Projects; Population; Pregnancy; Primates; Principal Investigator; Recruitment Activity; Reporting; Research; Research Infrastructure; Resources; Risk; Serum; Source; United States National Institutes of Health; blood glucose regulation; cardiovascular disorder risk; cohort; cost; feeding; glucose tolerance; offspring; pregnant; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Gestational diabetes mellitus (GDM) is an increasingly prevalent problem with important health and societal impact, yet controversies continue in the most elementary issues related to GDM. While clinical studies are assessing the effects of maternal hyperglycemia on subsequent development of obesity, insulin resistance, diabetes, and cardiovascular disease risk in the offspring, progress is hampered by the absence of a good experimental animal model. While clinicians report that frank gestational diabetes is rare in the monkey population at Yerkes, they are presented with only the most advanced cases. No systematic studies of glucose tolerance have been done in the captive population. Last year, we initiated a pilot project to identify pregnant female rhesus monkeys at risk for gestational diabetes. Of 10 females studied during pregnancy, three have serum glucose in excess of 160 mg/dl, clearly indicative of potential problems with glucose regulation. Data are being collected on a large number of rhesus females to better understand the incidence in our population. In addition a second cohort of adult females were recruited to be fed a high fat, high sugar diet during pregnancy and the early post partum period to determine how macronutrituient content influences gestational glucose regulation and what consequences these may have on post natal development of the offspring. The data generated in these studies will serve as the nucleus for grants submitted to the NIH (e.g. NICHD, NIDDK, NHLBI) and foundations, such as the American Diabetes Association and March of Dimes.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 妊娠糖尿病 (GDM) 是一个日益普遍的问题，具有重要的健康和社会影响，但与 GDM 相关的最基本问题仍然存在争议。 虽然临床研究正在评估母亲高血糖对后代肥胖、胰岛素抵抗、糖尿病和心血管疾病风险的影响，但由于缺乏良好的实验动物模型，进展受到阻碍。虽然临床医生报告说，在耶克斯的猴群中，明显的妊娠糖尿病很少见，但他们只看到了最晚期的病例。 尚未对圈养种群进行葡萄糖耐量的系统研究。去年，我们启动了一个试点项目，以确定怀孕的雌性恒河猴是否有妊娠糖尿病的风险。 在怀孕期间研究的 10 名女性中，有 3 名的血糖超过 160 mg/dl，这清楚地表明血糖调节存在潜在问题。 正在收集大量雌性恒河猴的数据，以更好地了解我们人口中的发病率。 此外，还招募了第二组成年女性，让其在怀孕期间和产后早期接受高脂肪、高糖饮食，以确定常量营养素含量如何影响妊娠血糖调节以及这些营养素可能对后代的产后发育产生什么影响。 这些研究中生成的数据将作为向 NIH（例如 NICHD、NIDDK、NHLBI）和美国糖尿病协会和 March of Dimes 等基金会提交的资助的核心。