UT M.D. Anderson Cancer Center Lymphoma SPORE

UT M.D. 安德森癌症中心淋巴瘤孢子

• 批准号: 7922023
• 负责人: ANAS YOUNES
• 金额: $ 50万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922023
• 关键词: UT; M.D.; Anderson; Cancer; Center

The University of Texas M. D. Anderson Cancer Center is proposing a Lymphoma Specialized Program of Research Excellence (SPORE). The primary goal of this Lymphoma SPORE is to improve the cure rate of lymphoma through innovative therapeutic strategies based on effective and focused translation of recent discoveries in lymphoma biology, immunology, and molecular genetics. The M. D. Anderson Lymphoma SPORE is a multidisciplinary collaborative effort between basic and translational scientists, clinical investigators, hematopathologists, and biostatisticians that is organized in 4 research projects and 4 core resources, as well as programs for developmental research and career development program. The research projects listed are designed to target specific areas important in lymphoma: Project 1 - Epigenetic-based therapy of Hodgkin lymphoma (Liu/Younes) Project 2 - Development of 8-chloro-adenosine therapy (Gandhi/McLaughlin) Project 3 - Targeting MDM2/P53 in ALL (Andreeff/O'Brien) Project 4 - Gene expression profiling and pathway targeted therapy in peripheral T-cell lymphoma (Chan/Vose) Core and other resources are the following: Core A - Administrative Core B - Biospecimen Core C - Clinical Research Core D - Biostatistics and Bioinformatics Development Research Program (DRP) and Career Development Program (CDP)

德克萨斯大学M. D. Anderson癌症中心正在提出一项卓越研究淋巴瘤专业计划（Spore）。该淋巴瘤孢子的主要目标是通过创新的治疗策略来提高淋巴瘤的治愈率，基于对淋巴瘤生物学，免疫学和分子遗传学最新发现的有效和重点翻译。 M. D. Anderson淋巴瘤孢子是基础科学家和转化科学家，临床研究者，血管病理学家和生物统计学家之间的多学科合作，该协作在4个研究项目和4个核心资源以及发展研究和职业发展计划的计划中。 列出的研究项目旨在针对淋巴瘤重要的特定领域： 项目1-基于表观遗传学的霍奇金淋巴瘤（LIU/YOUNES） 项目2-开发8-氯 - 腺苷疗法（Gandhi/McLaughlin） 项目3-全部针对MDM2/P53（Andreeff/O'Brien） 项目4-外周T细胞淋巴瘤（CHAN/VOSE）中靶向治疗的基因表达分析和途径 核心和其他资源如下： 核心A-管理 核心B-生物测试 核心C-临床研究 核心D-生物统计学和生物信息学 发展研究计划（DRP）和职业发展计划（CDP）