Listeria-based vaccines engineered to modulate the innate immune system

基于李斯特菌的疫苗旨在调节先天免疫系统

• 批准号: 8296801
• 负责人: DANIEL A PORTNOY
• 金额: $ 35.51万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8296801
• 关键词: Affect; Amino Acids; Antibody Formation; Antigens; Attenuated; Bacteriophages; Biological Assay; Breeding; CD8B1 gene; Cancer Vaccines; Caspase-1; Cell Death; Cells; Cellular Immunity; Cellular biology; Chimeric Proteins; Chromosomes; Clinical; Clinical Trials; Collaborations; Collection; Communicable Diseases; Cytolysis; Cytosol; DNA; Dendritic Cells; Development; Dose; Drug Formulations; Engineering; Flagellin; Generations; Genes; Genetic; Goals; Growth; Human; Immune; Immune response; Immune system; Immunity; Immunization; In Vitro; Infection; Interferon Type I; Interferons; Interleukin-1; Knockout Mice; Knowledge; Laboratories; Lead; Life; Life Cycle Stages; Ligands; Listeria; Listeria monocytogenes; Malaria; Malignant Neoplasms; Measures; Mediating; Modeling; Monitor; Mus; Mutation; Natural Immunity; Ovalbumin; Pathway interactions; Plasmodium berghei; Pre-Clinical Model; Production; Property; Proteins; Recombinants; Role; T cell response; T-Lymphocyte; T-Lymphocyte Epitopes; Testing; Therapeutic; Time; Vaccines; Vaccinia; Vaccinium; Work; abstracting; acquired immunity; base; biodefense; cell mediated immune response; cytotoxicity; efflux pump; fitness; global health; immunogenicity; in vivo; insight; macrophage; mouse model; mutant; nonhuman primate; overexpression; pathogen; phosphoric diester hydrolase; preclinical study; response; therapeutic vaccine; tool; vaccine candidate; vaccine development; vector; vector vaccine; vector-based vaccine