Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin

颗粒体蛋白前体对 IL-10 基因表达和宿主败血症反应的调节

• 批准号: 8310364
• 负责人: XIAOJING MA
• 金额: $ 25.35万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8310364
• 关键词: Address; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Bacteria; Binding; Bone Marrow; Brain; CCL2 gene; Clinical; Dependency; Development; Disease; Elastases; Endotoxemia; Endotoxins; Equilibrium; Foundations; Gene Expression; Genes; Genetic Transcription; Glycoproteins; Goals; Hematopoiesis; Homeostasis; Host Defense; Human; IL10 gene; Immune; Immune Tolerance; Immune response; In Vitro; Infection; Inflammation; Inflammatory; Inflammatory Response; Interleukin-10; Interleukin-12; Interleukin-6; Intervention; Knock-out; Knockout Mice; Lead; Ligation; Liquid substance; Listeria monocytogenes; Liver; Luciferases; Mediating; Microbe; Modification; Molecular; Mus; Natural Immunity; Peptides; Play; Positioning Attribute; Predisposition; Production; Progranulin; Proteins; Puncture procedure; Recombinants; Regulation; Reporter; Respiratory Burst; Role; Sepsis; Sepsis Syndrome; Septic Shock; Series; Serine Proteinase Inhibitors; Spleen; Stimulus; TNF gene; Testing; Tissues; Transgenes; Trauma; Wound Healing; activating transcription factor; antileukoprotease; antimicrobial; chromatin remodeling; chymotrypsin; cytokine; effective intervention; granulin; histone modification; human SLPI protein; in vivo; insight; macrophage; microbial; monocyte; neutrophil; novel; novel strategies; promoter; response; septic; transcription factor