Development of pan-filoviral inhibitors of replication targeting VP35 proteins

开发针对 VP35 蛋白的泛丝状病毒复制抑制剂

• 批准号: 8321747
• 负责人: Christopher F Basler
• 金额: $ 76.12万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321747
• 关键词: Affinity; Antiviral Agents; Antiviral Response; Binding; Biochemical; Biochemistry; Biological Assay; Biological Availability; Bioterrorism; Categories; Cell Culture Techniques; Cells; Chemistry; Complex; Computational Biology; Computer Simulation; Cytochrome P450; DNA-Directed RNA Polymerase; Data; Democratic Republic of the Congo; Development; Disease Outbreaks; Double-Stranded RNA; Drug Kinetics; Ebola virus; Exhibits; Filovirus; Frankfurt-Marburg Syndrome Virus; Germ Cells; Goals; Health; Human; Immunity; Immunosuppression; In Vitro; Interdisciplinary Study; Interferons; Knowledge; Laboratories; Lead; Metabolic; Molecular; Mus; National Institute of Allergy and Infectious Disease; Nature; Nucleoproteins; Organic Chemistry; Pathogenesis; Pathway interactions; Pharmaceutical Chemistry; Pharmaceutical Preparations; Polymerase; Preclinical Drug Development; Preclinical Drug Evaluation; Production; Proteins; RNA Viruses; RNA chemical synthesis; RNA replication; Research; Research Personnel; Resolution; Reston; Role; Signal Pathway; Specificity; Structure; Synthesis Chemistry; Therapeutic; Toxic effect; Toxicology; Viral; Viral Hemorrhagic Fevers; Virulence; Virulent; Virus Diseases; Work; X-Ray Crystallography; analog; base; drug development; in vitro activity; in vitro testing; inhibitor/antagonist; insight; interest; mutant; pathogen; pre-clinical; programs; response; scaffold; small molecule; structural biology; therapeutic development; viral RNA; virology; virtual