Management and Retrieval of Multidisciplinary HIV Research Data

多学科 HIV 研究数据的管理和检索

基本信息

批准号：
8019466
负责人：
JAMES Ivan MULLINS
金额：
$ 24.65万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-15 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8019466
关键词：
Acquired Immunodeficiency Syndrome Address Adoption Bioinformatics Biological Biological Assay Biological Models Client Clinic Clinical Collaborations Communicable Diseases Communities Computational Biology Computer software Computers Cytotoxic T-Lymphocytes Data Data Analyses Data Set Data Storage and Retrieval Databases Development Diagnostic Disease Electronics Etiology Failure Fostering Genes Genetic Goals HIV HLA Antigens Housing Human Individual Infection prevention Institution Laboratories Link Location Manuals Methods Modeling Molecular Genetics Notification Nucleic Acids Outcome Pathogenesis Pharmaceutical Preparations Procedures Process Public Health Recording of previous events Recovery Research Research Infrastructure Research Personnel Resources Retrieval Sampling Science Scientist Series Site Source Specimen Testing Vaccine Design Validation Viral Work abstracting analytical tool base clinically relevant cohort data acquisition database structure immune resistance interoperability microbial multidisciplinary novel open source pathogen public health relevance quality assurance reconstitution relational database repository research clinical testing research study tool tool development web services

项目摘要

DESCRIPTION (provided by applicant): Title: Management and Retrieval of Multidisciplinary HIV Research Data Abstract We propose to build a relational database and bioinformatics toolkit to provide a software infrastructure for the acquisition, retention and evaluation of clinical, laboratory and genetic data derived from microbial pathogens and their infected human hosts. With the goal of discovering mechanisms of disease causation and means of preventing infection and disease, as well as addressing an urgent public health problem, we will develop the toolkit with a focus on HIV as a prototypical viral infectious disease. To assure interoperability and maximal util- ity, the toolkit will be developed in collaboration with prominent investigators who are together responsible for much of the leading edge data acquisition and analysis in the HIV field today. The database and accompany- ing tools will dynamically link all available data to allow a large array of collaborating scientists to easily track the clinical histories, current status, experimental results and analyses for all subjects and specimens. It will serve as a fully searchable resource for all work leading to the finalized data and as a source for integrated data analysis. PUBLIC HEALTH RELEVANCE: We propose to expand and refine a new database and bioinformatics toolkit that will include a relational database and toolkit that together comprise a software infrastructure to be used for the acquisition, retention and evaluation of clinical, laboratory and genetic data derived from microbial pathogens and their infected human hosts. With the goal of discovering mechanisms of disease causation and means of preventing infection and disease, as well as addressing an urgent public health problem, we will focus on HIV as a prototypical viral infectious disease.

描述（由申请人提供）：标题：多学科 HIV 研究数据的管理和检索摘要我们建议建立一个关系数据库和生物信息学工具包，为获取、保留和评估源自微生物的临床、实验室和遗传数据提供软件基础设施。病原体及其感染的人类宿主。为了发现致病机制和预防感染和疾病的方法，以及解决紧迫的公共卫生问题，我们将开发该工具包，重点关注艾滋病毒这种典型的病毒传染病。为了确保互操作性和最大实用性，该工具包将与著名研究人员合作开发，这些研究人员共同负责当今艾滋病毒领域的大部分前沿数据采集和分析。该数据库和随附工具将动态链接所有可用数据，使大量合作科学家能够轻松跟踪所有受试者和标本的临床病史、当前状态、实验结果和分析。它将作为最终数据所有工作的完全可搜索资源，并作为综合数据分析的来源。公共卫生相关性：我们建议扩展和完善一个新的数据库和生物信息学工具包，其中包括一个关系数据库和工具包，它们共同构成一个软件基础设施，用于获取、保留和评估源自微生物的临床、实验室和遗传数据。病原体及其感染的人类宿主。为了发现致病机制和预防感染和疾病的方法，以及解决紧迫的公共卫生问题，我们将重点关注艾滋病毒作为一种典型的病毒传染病。