Neuromuscular control of the human tongue

人类舌头的神经肌肉控制

• 批准号: 8131677
• 负责人: E. FIONA BAILEY
• 金额: $ 35.99万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8131677
• 关键词: Action Potentials; Axon; Behavior; Breathing; Complex; Data; Deglutition; Development; Diagnosis; Elements; Exhibits; Goals; Human; Intervention; Investigation; Larynx; Libraries; Mastication; Motor; Motor Cortex; Motor Neurons; Movement; Muscle; Muscle Fibers; Muscle function; Nervous system structure; Neuraxis; Oral; Organ; Output; Pattern; Phonation; Process; Production; Property; Relative (related person); Respiration; Respiratory Muscles; Rest; Skeletal Muscle; Sleep; Speech; Speech Disorders; Synapses; System; Techniques; Testing; Therapeutic; Time; Tongue; Work; base; bone; central pattern generator; design; human subject; insight; lung volume; minimally invasive; neuromuscular; neuroregulation; presynaptic; public health relevance; relating to nervous system; research study; respiratory; tongue root

DESCRIPTION (provided by applicant): The tongue is a complex muscular organ that is critical for oro-motor behaviors such as swallowing, breathing, speaking and chewing. The astonishing complexity and precision of the voluntary movements performed by the tongue depend upon the coordination of intrinsic (origin and insertion within the body of the tongue) and extrinsic (attached to bone and inserted into the base of tongue) tongue muscles. Until recently, almost all studies of lingual muscle function whether in speech, respiration or deglutition have concerned themselves with the study of whole muscle electromyographic (EMG) activities. Recently, we characterized respiratory-related tongue muscle and motor unit activities in healthy human subjects as a function of sleep/wake and in slow volitional movements. The results of this work provided de novo insights into lingual motor function and a platform from which to begin studies aimed at identifying how tongue muscles are controlled in more complex volitional behaviors. The current application builds thematically on previous work by the PI and yet departs from previous investigations in incorporating critical elements of the speech production process. Specifically, we propose to examine tongue muscle and motor unit activities and the potential for these activities to be modulated by inputs arising in the respiratory, phonatory (laryngeal) and/or supralaryngeal (oral- articulatory) subsystems. Understanding muscle and MU activities as a function of these influences separately and when successively overlaid is a logical first-step toward understanding how tongue muscle and motor unit activities are modulated in the more complex volitional behavior that is human speech production. PUBLIC HEALTH RELEVANCE: The human tongue is perhaps one of the most complex, challenging, and least understood of all motor systems. This application outlines a plan to identify the fundamental processes by which the central nervous system controls tongue movement for speech.

描述（由申请人提供）：舌头是一个复杂的肌肉器官，对于吞咽，呼吸，口语和咀嚼等诸如Oro-Motor行为至关重要。舌头执行的自愿运动的惊人复杂性和精度取决于固有的（舌体内的起源和插入）和外在（附着在骨头上并插入舌头的舌头）肌肉的协调。直到最近，几乎所有关于语音，呼吸或退化中的舌肌功能的研究都与整个肌肉肌电图（EMG）活性的研究有关。最近，我们表征了健康人类受试者中与呼吸有关的舌头肌肉和运动单位活动，这是睡眠/唤醒和自愿运动缓慢的功能。这项工作的结果为舌运动功能提供了从头洞察力，以及一个旨在确定舌头肌肉如何以更复杂的自愿行为控制的平台。当前的应用程序以PI为主题为主题，但在整合语音生产过程的关键要素时与先前的调查背道而驰。具体而言，我们建议检查舌头肌肉和运动单位活动，并通过在呼吸道，语音（喉）和/或supralaryngeal（口腔宣传）子系统中引起的投入来调节这些活动。将肌肉和MU活动分别理解为这些影响的函数，而持续覆盖是一个合乎逻辑的第一步，以了解舌头肌肉和运动单位活动如何在人类言语产生的更复杂的自愿行为中调节。 公共卫生相关性：人类舌头可能是所有运动系统中最复杂，最具挑战性和最不明智的一种。该应用程序概述了一个计划，以确定中枢神经系统控制舌头运动的基本过程。