Neuromuscular control of the tongue

舌头的神经肌肉控制

• 批准号: 7089877
• 负责人: E. FIONA BAILEY
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7089877
• 关键词: clinical research; human subject; hypoglossal nerve; motor neurons; neuromuscular function; neurophysiology; patient oriented research; polysomnography; pulmonary respiration; sleep; tongue; wakefulness; clinical research; human subject; hypoglossal nerve; motor neurons; neuromuscular function; neurophysiology; patient oriented research; polysomnography; pulmonary respiration; sleep; tongue; wakefulness

DESCRIPTION (provided by applicant): This application outlines a plan to conduct research examining the respiratory-related neuromuscular control of the tongue. The plan proposes a series of experiments to be conducted in human subjects that will examine the modulation of human hypoglossal motor unit activities as a function of sleep and wakefulness, in response to respiratory-related sensory stimuli and during volitional movement. These experiments will provide insights into the nervous system (efferent and afferent components) control of the tongue muscles in healthy human subjects that will have implications for the neural control of movement in the broadest sense. The application includes a plan for the acquisition of new theoretical knowledge in cell physiology, systems neurobiology, sleep physiology and practical skills in human neurophysiology, polysomnography and sleep staging. The plan has tremendous potential and will provide the foundation for future studies of lingual motor control in upper airway muscles during more complex oromotor functions such as swallowing. Additional training is needed by the candidate to achieve this potential since the human neurophysiological, polysomnography, sleep state assessment and data analysis techniques are all new to her. The training proposed in this application will extend and develop upon the candidate's previous research experience studying the respiratory-related control of tongue muscle activities in the spontaneously breathing anesthetized rat. The candidate will work with a select group of highly talented co-mentors who will provide expertise in respiratory physiology, sleep and sleep disorders, neurophysiology and motor control. The candidate proposes to conduct all research at the University of Arizona, which offers state of the art facilities for the study of respiratory, sleep and neurophysiology in human subjects and offers advanced courses in cell biology, systems neurobiology, sleep and sleep disorders. Receipt of this award will enable the candidate to go on to develop an independent research program that combines behavioral and neurophysiological approaches to study lingual neuromuscular control in human and lower mammalian model systems.

描述（由申请人提供）：本申请概述了一项计划，以研究研究舌头的呼吸相关神经肌肉控制。该计划建议在人类受试者中进行一系列实验，该实验将检查人类降压运动单位活性的调节，这是睡眠和清醒的函数，以响应与呼吸相关的感觉刺激和自愿运动。这些实验将提供对健康人受试者舌肌的神经系统（传出和传染性成分）的见解，这些肌肉将对最广泛的运动对运动的神经控制产生影响。该应用程序包括一项计划，以获取细胞生理学，系统神经生物学，睡眠生理学和人类神经生理学，多性疗法和睡眠阶段方面的新理论知识。该计划具有巨大的潜力，并将为在更复杂的Oromotor功能（例如吞咽）功能期间对未来在上呼吸道肌肉中进行舌运动控制的基础。候选人需要额外的培训来实现这一潜力，因为人类的神经生理学，多种志摄影，睡眠状态评估和数据分析技术对她来说都是新的。本应用程序中提出的培训将扩展和发展候选人的先前研究经验，该研究经验研究了自发呼吸麻醉大鼠对呼吸相关的舌肌活动的控制。候选人将与一群有才华的同事一起工作，他们将提供呼吸生理，睡眠和睡眠障碍，神经生理学和运动控制方面的专业知识。候选人建议在亚利桑那大学进行所有研究，该大学为人类受试者提供呼吸，睡眠和神经生理学研究的最先进的设施，并提供细胞生物学，系统神经生物学，睡眠和睡眠障碍的先进课程。该奖项的收到将使候选人能够继续制定一个独立的研究计划，该计划结合了人类和下哺乳动物模型系统中的行为和神经生理方法来研究舌神经肌肉控制。