DEVELOPMENT OF METABOLIC SYNDROME IN FILIPINO, NATIVE HAWAIIAN AND SAMOAN YOUTH

菲律宾、夏威夷本土和萨摩亚青年代谢综合征的发生情况

• 批准号: 8085921
• 负责人: May Michiko Okihiro
• 金额: $ 33.8万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8085921
• 关键词: Adolescence; Adolescent; Adult; Asians; Body Composition; Cardiovascular Diseases; Child; Childhood; Communities; Community Health Centers; Data; Development; Diabetes Mellitus; Epidemic; Ethnic group; Filipino; Gestational Diabetes; Glucose; Growth; Hawaii; Hawaiian population; High Prevalence; Hormonal; Individual; Insulin Resistance; Laboratory Markers; Laboratory Study; Lead; Life; Light; Lipids; Measurement; Medical Records; Metabolic; Metabolic syndrome; Mexican Americans; National Health and Nutrition Examination Survey; Native Americans; Obesity; Overweight; Pacific Island Americans; Pacific Islands; Pathogenesis; Pattern; Phenotype; Physiological; Population; Pregnancy; Prevalence; Prevention; Public Health; Recruitment Activity; Reporting; Risk; Risk Factors; Samoan; Surveys; United States National Institutes of Health; Youth; base; blood pressure regulation; cardiovascular disorder risk; diabetes risk; early childhood; high risk; obesity in children; prevent; rapid growth; treatment program

The recent and dramatic increase in the obesity prevalence has been followed closely by a rapidly rising prevalence of metabolic complications, especially diabetes and the metabolic syndrome, a well recognized, but poorly understood condition involving lipid, glucose and hormonal dysregulation associated with increased risk for cardiovascular disease. The prevalence of MS has increased significantly among adults over the last 20 years to 23.7%. More worrisome, over 30% of overweight adolescents in the NHANES 1999- 2000 survey were found to have a MS phenotype. Obesity and diabetes are common among certain ethnic groups including Asians, Native Hawaiians and other Pacific Islanders (PI). MS is also more common among certain ethnic groups including NH and Asians adults, especially Filipinos. Filipino, NH and other PI children have a high prevalence of obesity but prevalence of MS is not known. In light of the high prevalence of childhood obesity and adult MS, Filipino, NH and other PI children may be particularly susceptible to the development of MS. Physiologic abnormalities that appear to be MS may be reversible initially but become stable later and much more difficult to treat. This reversibility underscores the idea that in order to understand MS, and develop effective prevention and treatment programs, we need to understand how it develops in childhood, especially in diverse, high-risk populations such as Asian and PI. The specific aims of this study are to 1) To determine the prevalence of MS in a high-risk population of overweight Filipino, NH, and Samoan adolescents 2) To examine the pattern of physical and laboratory markers associated with the development MS in a high-risk population of children 3) To examine the relationship between gestational and early childhood factors and the development of MS/ The study will be a cross-sectional community-based study of 450 Filipino, NH and Samoan overweight and at risk for overweight youth recruited from community health centers in Hawaii and surrounding community groups. Subjects will undergo anthropometric measurement, body composition analysis and laboratory studies to determine which overweight adolescents have a MS phenotype. Medical records will be reviewed to collect pregnancy, child growth data and determine associations with the development of MS. PUBLIC: Metabolic syndrome (MS) is a common and serious consequence of obesity involving problems with lipid, glucose and blood pressure regulation and increases risk of developing cardiovascular disease. Like obesity, it is becoming more common in children but little is known about how it develops. This study will determine how common MS is in a population of high-risk, understudied Asian and Pacific Island children and examine the relationship between factors in pregnancy and early childhood and the onset of MS.

最近肥胖患病率急剧上升，紧随其后的是肥胖患病率的迅速上升。 代谢并发症的患病率，特别是糖尿病和代谢综合征，这是一个公认的、 但人们对涉及脂质、葡萄糖和激素失调的病症知之甚少 心血管疾病的风险增加。成年人中多发性硬化症的患病率显着增加 过去 20 年上升至 23.7%。更令人担忧的是，1999 年 NHANES 中超过 30% 的青少年超重 2000年调查发现具有MS表型。 肥胖和糖尿病在某些种族群体中很常见，包括亚洲人、夏威夷原住民和 其他太平洋岛民 (PI)。 MS 在某些种族群体中也更常见，包括新罕布什尔州和亚洲人 成年人，尤其是菲律宾人。菲律宾、新罕布什尔州和其他菲律宾儿童的肥胖率很高，但 MS 的患病率尚不清楚。鉴于儿童肥胖症和成人多发性硬化症的患病率很高，菲律宾人 NH 和其他 PI 儿童可能特别容易患 MS。 看似多发性硬化症的生理异常最初可能是可逆的，但后来会变得稳定， 治疗起来更加困难。这种可逆性强调了这样的想法：为了理解 MS， 制定有效的预防和治疗方案，我们需要了解它在儿童时期是如何发展的， 尤其是在亚洲和 PI 等多样化的高风险人群中。 本研究的具体目的是 1) 确定 MS 在高危人群中的患病率 超重的菲律宾、新罕布什尔州和萨摩亚青少年 2) 检查身体和实验室的模式 与高危儿童人群中发展 MS 相关的标志物 3) 检查 妊娠和幼儿期因素与 MS/ 发展之间的关系 该研究将以社区为基础，对 450 名超重的菲律宾人、新罕布什尔州人和萨摩亚人进行横断面研究 从夏威夷及周边地区的社区卫生中心招募的超重青少年面临风险 社区团体。受试者将接受人体测量、身体成分分析和 实验室研究以确定哪些超重青少年具有多发性硬化症表型。医疗记录将会 进行审查以收集怀孕、儿童生长数据并确定与多发性硬化症发展的关联。 公众：代谢综合征 (MS) 是肥胖引起的常见且严重的后果 与血脂、血糖和血压调节有关，会增加患心血管疾病的风险。 与肥胖一样，它在儿童中变得越来越普遍，但人们对其如何发展却知之甚少。这项研究将 确定多发性硬化症在高风险且研究不足的亚洲和太平洋岛屿儿童群体中的常见程度 并研究妊娠和幼儿时期的因素与多发性硬化症发病之间的关系。