DEVELOPMENT OF METABOLIC SYNDROME IN FILIPINO, NATIVE HAWAIIAN AND SAMOAN YOUTH

菲律宾、夏威夷本土和萨摩亚青年代谢综合征的发生情况

• 批准号: 8286806
• 负责人: May Michiko Okihiro
• 金额: $ 34.38万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2012-12-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8286806
• 关键词: Adolescence; Adolescent; Adult; Asians; Body Composition; Cardiovascular Diseases; Child; Childhood; Communities; Community Health Centers; Data; Development; Diabetes Mellitus; Epidemic; Ethnic group; Filipino; Gestational Diabetes; Glucose; Growth; Hawaii; Hawaiian population; High Prevalence; Hormonal; Individual; Insulin Resistance; Laboratory Markers; Laboratory Study; Lead; Life; Light; Lipids; Measurement; Medical Records; Metabolic; Metabolic syndrome; Mexican Americans; National Health and Nutrition Examination Survey; Native Americans; Obesity; Overweight; Pacific Island Americans; Pacific Islands; Pathogenesis; Pattern; Phenotype; Physiological; Population; Pregnancy; Prevalence; Prevention program; Public Health; Recruitment Activity; Reporting; Request for Applications; Risk; Risk Factors; Samoan; Surveys; Youth; base; blood pressure regulation; cardiovascular disorder risk; diabetes risk; early childhood; high risk; obesity in children; prevent; rapid growth; treatment program

The recent and dramatic increase in the obesity prevalence has been followed closely by a rapidly rising prevalence of metabolic complications, especially diabetes and the metabolic syndrome, a well recognized, but poorly understood condition involving lipid, glucose and hormonal dysregulation associated with increased risk for cardiovascular disease. The prevalence of MS has increased significantly among adults over the last 20 years to 23.7%. More worrisome, over 30% of overweight adolescents in the NHANES 1999- 2000 survey were found to have a MS phenotype. Obesity and diabetes are common among certain ethnic groups including Asians, Native Hawaiians and other Pacific Islanders (PI). MS is also more common among certain ethnic groups including NH and Asians adults, especially Filipinos. Filipino, NH and other PI children have a high prevalence of obesity but prevalence of MS is not known. In light of the high prevalence of childhood obesity and adult MS, Filipino, NH and other PI children may be particularly susceptible to the development of MS. Physiologic abnormalities that appear to be MS may be reversible initially but become stable later and much more difficult to treat. This reversibility underscores the idea that in order to understand MS, and develop effective prevention and treatment programs, we need to understand how it develops in childhood, especially in diverse, high-risk populations such as Asian and PI. The specific aims of this study are to 1) To determine the prevalence of MS in a high-risk population of overweight Filipino, NH, and Samoan adolescents 2) To examine the pattern of physical and laboratory markers associated with the development MS in a high-risk population of children 3) To examine the relationship between gestational and early childhood factors and the development of MS/ The study will be a cross-sectional community-based study of 450 Filipino, NH and Samoan overweight and at risk for overweight youth recruited from community health centers in Hawaii and surrounding community groups. Subjects will undergo anthropometric measurement, body composition analysis and laboratory studies to determine which overweight adolescents have a MS phenotype. Medical records will be reviewed to collect pregnancy, child growth data and determine associations with the development of MS. PUBLIC: Metabolic syndrome (MS) is a common and serious consequence of obesity involving problems with lipid, glucose and blood pressure regulation and increases risk of developing cardiovascular disease. Like obesity, it is becoming more common in children but little is known about how it develops. This study will determine how common MS is in a population of high-risk, understudied Asian and Pacific Island children and examine the relationship between factors in pregnancy and early childhood and the onset of MS.

肥胖症患病率的最近和急剧增加，紧随其后的是迅速上升 代谢并发症的患病率，尤其是糖尿病和代谢综合征，一种公认的， 但是涉及脂质，葡萄糖和激素失调的状况知之甚少 心血管疾病的风险增加。成年人中MS的患病率显着增加 在过去的20年中，至23.7％。更令人担忧，超过30％的NHANES超重青少年1999- 发现2000年的调查具有MS表型。 肥胖和糖尿病在某些种族中很常见，包括亚洲人，夏威夷原住民和 其他太平洋岛民（PI）。 MS在包括NH和亚洲人在内的某些族裔中也更为普遍 成人，尤其是菲律宾人。菲律宾，NH和其他PI儿童的肥胖症患病率很高，但 MS的患病率尚不清楚。鉴于儿童肥胖症和成人MS的高患病率，菲律宾 NH和其他PI儿童可能特别容易受到MS的发展。 最初似乎是MS的生理异常可能是可逆的，但以后变得稳定， 更难治疗。这种可逆性强调了为了了解MS的想法，并且 制定有效的预防和治疗计划，我们需要了解它在童年时代的发展方式， 特别是在各种高风险的人群中，例如亚洲和PI。 这项研究的具体目的是1）确定高危人群中MS的患病率 超重菲律宾，NH和萨摩亚青少年2）检查物理和实验室的模式 高危儿童中与发展MS相关的标记3）检查 妊娠与幼儿因素之间的关系以及MS/的发展 该研究将是一项基于横断面的社区研究，对450菲律宾，NH和萨摩亚超重 并有从夏威夷及周边社区卫生中心招募的超重青年的风险 社区团体。受试者将进行人体测量，身体成分分析和 实验室研究以确定哪些超重青少年具有MS表型。病历将是 审查以收集怀孕，儿童成长数据并确定与MS的发展相关。 公共：代谢综合征（MS）是肥胖的常见和严重的后果 随着脂质，葡萄糖和血压调节，并增加患心血管疾病的风险。 像肥胖一样，它在儿童中变得越来越普遍，但对它的发展方式知之甚少。这项研究会 确定MS在高风险，研究的亚洲和太平洋岛儿童中的普遍性 并检查怀孕与幼儿时因素与MS发作之间的关系。