North Carolina A&T University-Wake Forest Cancer Center partnership (2 of 2)

北卡罗来纳州A

• 批准号: 7913029
• 负责人: STEVEN A AKMAN
• 金额: $ 13.28万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7913029
• 关键词: 3-hydroxybutanal; Agriculture; Animal Cancer Model; Animal Model; Biological Assay; Biology; Boronic Acids; Brain Neoplasms; CCL7 gene; Cancer Biology; Cancer Center; Cell Line; Cell Mobility; Cells; Chemistry; Chemoprevention; Chemopreventive Agent; Collaborations; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Computational Biology; DU145; Data; Doctor of Philosophy; Educational process of instructing; Engineering; Enrollment; Enzymes; Evaluation; Faculty; Fostering; Funding; Funding Agency; GSTP1 gene; Genetic; Glioblastoma; Goals; Grant; Growth; Hour; In Vitro; Incidence; Institution; Joints; Knock-out; LNCaP; Laboratories; Malignant Epithelial Cell; Malignant Neoplasms; Malignant neoplasm of prostate; Master' s Degree; Measurement; Mentors; Methods; Minority; Modeling; Mus; NAD(P)H dehydrogenase (quinone) 1, human; NQO1 gene; North Carolina; PTEN gene; Phase; Physical condensation; Pilot Projects; Polyunsaturated Fatty Acids; Preparation; Process; Production; Prostate; Prostate carcinoma; Research; Research Project Grants; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Role; Structure-Activity Relationship; Students; Testing; Therapeutic; Universities; Western Blotting; Writing; anticancer research; base; cancer cell; cancer genomics; cancer health disparity; cancer therapy; carcinogenesis; career development; cytotoxicity; enzyme activity; evidence base; forest; health disparity; in vivo; in vivo Model; innovation; interest; mouse model; novel; outreach; prevent; professor; programs; transcription factor; treatment strategy

DESCRIPTION (provided by applicant): This P20 proposal presents a research and educational partnership between the Wake Forest University Comprehensive Cancer Center (WFUCCC) and the Departments of Biology and Chemistry of North Carolina Agricultural and Technical University (NC A&T). The objectives of the partnership are: (1) to foster cancer research collaborations between WFUCCC and NC A&T, especially research focused on cancer disparities and to facilitate the career development of minority cancer research faculty at NC A&T through collaborations with and mentoring provided by the WFUCCC; (2) to foster interest in obtaining a PhD in cancer biology among minority undergraduate and Master's degree students at NC A&T. To achieve the first objective, the P20 will provide pilot funds for two collaborative research projects: (1) Drs. Suzy Torti and Yong Chen of the WFUCCC will mentor and collaborate with Dr. Marion Franks, Assistant Professor of Chemistry at NC A&T, on a project to synthesize and evaluate novel benzylidenes as prostate cancer chemopreventive agents; (2) Dr. Waldemar Debinski, Director of the Brain Tumor Center of the WFUCCC, will mentor and collaborate with Dr. Patrick Martin, Assistant Professor of Biology at NC A&T on a project to understand the role of transcription factor Fra1 in glioblastoma cell mobility and resistance to therapeutics. To achieve the second objective: (1) Selected RISE, MARC, and BLEND program undergraduates at NC A&T will participate in wet laboratory, computational biology, or health disparity outreach projects mentored by WFUCCC faculty; (2) Each pilot project team will select at least one NC A&T Master's degree student to ; participate in the project. The students will be offered the option of continued participation in the projects as PhD students in Cancer Biology at WFU; (3) WFUCCC and NC A&T faculty will collaborate to develop didactic teaching modules in cancer genomics and animal models of cancer for currently ongoing coursework at NC A&T. By the conclusion of the P20 it is expected that: (1) Drs. Franks and Martin and their WFUCCC collaborators will be writing joint RO1s; (2) The WFUCCC and NC A&T will be writing an R25 bridge application to support enrollment of NC A&T students in the PhD program in Cancer Biology at WFU.

描述（由申请人提供）：本 P20 提案提出了维克森林大学综合癌症中心 (WFUCCC) 与北卡罗来纳农业技术大学 (NC A&T) 生物系和化学系之间的研究和教育合作伙伴关系。该伙伴关系的目标是：(1) 促进 WFUCCC 和 NC A&T 之间的癌症研究合作，特别是针对癌症差异的研究，并通过与 WFUCCC 的合作和提供的指导，促进 NC A&T 少数族裔癌症研究人员的职业发展; (2) 培养 NC A&T 少数族裔本科生和硕士生获得癌症生物学博士学位的兴趣。为了实现第一个目标，P20将为两个合作研究项目提供试点资金：（1）Drs. WFUCCC 的 Suzy Torti 和 Yong Chen 将与 NC A&T 化学助理教授 Marion Franks 博士指导和合作开展一个项目，合成和评估作为前列腺癌化学预防剂的新型苯亚甲基； (2) WFUCCC 脑肿瘤中心主任 Waldemar Debinski 博士将与 NC A&T 生物学助理教授 Patrick Martin 博士指导和合作开展一个项目，以了解转录因子 Fra1 在胶质母细胞瘤细胞迁移中的作用和对治疗的抵抗力。为了实现第二个目标：(1) NC A&T 选定的 RISE、MARC 和 BLEND 项目本科生将参加由 WFUCCC 教师指导的湿实验室、计算生物学或健康差异外展项目； （2）每个试点项目组将至少选派一名NC A&T硕士生；参与该项目。学生将可以选择作为 WFU 癌症生物学博士生继续参与这些项目； (3) WFUCCC 和 NC A&T 教师将合作开发癌症基因组学和癌症动物模型方面的教学模块，用于 NC A&T 目前正在进行的课程。根据 P20 的结论，预计： (1) Drs. Franks 和 Martin 以及他们的 WFUCCC 合作者将联合编写 RO1； (2) WFUCCC 和 NC A&T 将编写 R25 过渡申请，以支持 NC A&T 学生注册 WFU 癌症生物学博士课程。