4/8- Predictors & Mechanisms of Conversion to Psychosis
4/8- 预测
基本信息
- 批准号:7516245
- 负责人:
- 金额:$ 40.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-30 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAdultAdvisory CommitteesAffectAffectiveAgeAge of OnsetAlgorithmsAmericanAntipsychotic AgentsAppendixAreaArtsAttentionAwardBiologicalBiological AssayBiological MarkersBiologyBrainCalibrationCaliforniaCandidate Disease GeneChronicClassificationClinicalClinical assessmentsCollaborationsCommitConsensusCore FacilityDNADSM-IVDataData SetDepthDeteriorationDevelopmentDiabetes MellitusDiagnosisDiagnosticDiseaseEP300 geneEarly DiagnosisEarly InterventionEconomicsElectrophysiology (science)ElementsEnrollmentEnsureEpidemiologyEtiologyEvaluationFamilyFamily history ofFunctional disorderFundingFutureGeneticGenetic PolymorphismGenetic Predisposition to DiseaseGenomeGenomicsGoalsGrantHPSE geneHeart DiseasesHeterogeneityHormonalHormonesHospitalsHydrocortisoneImageImpaired cognitionImpairmentIncidenceIndividualInfluentialsInformation NetworksInternationalInterventionInvestigationKnowledgeLaboratoriesLaboratory ProceduresLifeLightLiteratureLongitudinal StudiesLos AngelesMeasuresMedialMemoryMessenger RNAMeta-AnalysisMethodologyMethodsModelingMonitorNational Institute of Mental HealthNatural HistoryNeurobiologyNeurocognitionNeurocognitiveNeurocognitive DeficitNeuropsychologyNorth AmericaNorth CarolinaNumbersOccupationalOnset of illnessOutcomePaperParanoiaPathway interactionsPatientsPerformancePersonsPhasePoliciesPopulationPostdoctoral FellowPreparationPreventionPrevention interventionPrevention strategyPreventive InterventionProblem SolvingProcessProductivityProspective StudiesProtocols documentationPsychopathologyPsychosocial FactorPsychotic DisordersPublic HealthPublicationsPublishingRNARangeRateRecruitment ActivityReportingRequest for ApplicationsResearchResearch PersonnelRetrospective StudiesRiskRisk FactorsRoleSample SizeSamplingSchizophreniaScienceScoreSeminalSeriesSiteSocietiesStagingStressStructureSubgroupSymptomsSyndromeSystemTemporal LobeTestingThinkingTimeTractionTrainingTwin StudiesUniversitiesVisitWalkersWood materialWorkaffective psychosesbasecareercluster computingdeviantendophenotypeexecutive functionexperiencefollow-upgenetic associationgenome wide association studygray matterhelp-seeking behaviorhypothalamic-pituitary-adrenal axisimage processingimprovedindexinginstrumentinterestlymphoblastoid cell linememberneuroimagingneuromechanismneurophysiologyneuropsychologicalpreventprogramsprospectivepsychogeneticspsychosocialrepositorysizesocialsocial cognitionsymposiumtraittreatment effect
项目摘要
DESCRIPTION (provided by applicant): Schizophrenia and other forms of psychosis affect approximately 3% of the population with a disorder that is usually chronic and disabling. The peak age of onset is between ages 18-30, occurring just as life's most productive years are beginning. Although genetic liability and abnormal brain development are known contributing factors, the etiology and pathophysiology of schizophrenia and related syndromes is largely unknown. To date, prospective observation of onset, i.e., the transition from vulnerability to disorder has not been possible because most persons at true risk cannot be identified premorbidly. This has hampered efforts at prevention. However, recent progress in risk ascertainment methodology has enabled reliable identification of help-seeking persons with pre-psychotic or "prodromal" clinical syndromes who develop psychosis within 1-2 years at rates between 20%-50%. Thus, clinical high-risk populations are now available for tracking prospectively the development and emergence of psychosis. However, because of the low incidence of schizophrenia and the heterogeneity of outcomes in clinical high-risk cases, single site studies cannot efficiently exploit the risk criteria in identifying predictors and mechanisms of psychosis. The NAPLS consortium was created to solve this problem. Eight NIMH-funded sites in North America studying prodromal patients using a common prodromal assessment instrument pooled data to create the largest sample of such persons worldwide (N=291), 35% of whom converted to psychosis after 2 years. An algorithm of baseline data was generated predicting psychosis with about 80% positive predictive power and 40% sensitivity. In this revised proposal, we describe a collaborative prospective study for which we will recruit 800 cases and 400 appropriate controls over 5 years using common, standardized clinical and neurobiological measures. The aim is to collect a sample with sufficient size and power to rigorously test elements critical to the liability for and development of psychosis in the biomarker domains of brain structure, electrophysiology, stress hormones, and genomics, and in the clinical domains of prodromal presentation and epidemiology. The revised proposal addresses reviewers' concerns, including the integration of the research plan and measures into a unifying framework. The findings will enhance our ability to identify persons at high risk for imminent psychosis, by refining predictors of conversion, and expanding our understanding of the underlying neural mechanisms. Such knowledge is critical for future efforts at early detection, intervention and prevention of psychotic disorders. PUBLIC HEALTH RELEVANCE: Preventing schizophrenia and other psychoses could relieve an enormous burden of personal and family suffering and economic losses to society. This 8-site project aims to increase our ability to identify high-risk individuals prior to onset and to pinpoint neurobiological changes that underlie the emergence of a psychotic disorder. These efforts are critical to the development of effective preventative intervention strategies for psychotic disorders.
描述(由申请人提供):约 3% 的人口患有精神分裂症和其他形式的精神病,这些疾病通常是慢性且致残的。发病高峰年龄在 18 岁至 30 岁之间,此时正值生命中生产力最高的时期开始。尽管遗传倾向和大脑发育异常是已知的促成因素,但精神分裂症及相关综合征的病因学和病理生理学在很大程度上尚不清楚。迄今为止,对发病情况(即从脆弱性到疾病的转变)的前瞻性观察尚不可能,因为大多数处于真正风险的人无法在病前识别。这阻碍了预防工作。然而,风险确定方法的最新进展已经能够可靠地识别患有精神病前期或“前驱期”临床综合征的寻求帮助者,这些人在 1-2 年内以 20%-50% 的比率发展为精神病。因此,临床高危人群现在可用于前瞻性追踪精神病的发展和出现。然而,由于精神分裂症的发病率低以及临床高风险病例结果的异质性,单中心研究无法有效利用风险标准来识别精神病的预测因素和机制。 NAPLS 联盟就是为了解决这个问题而创建的。北美 NIMH 资助的 8 个研究中心使用通用的前驱评估工具汇总数据,创建了全球此类患者的最大样本 (N=291),其中 35% 的患者在 2 年后转变为精神病。生成的基线数据算法可预测精神病,其阳性预测能力约为 80%,敏感性为 40%。在这份修订后的提案中,我们描述了一项合作前瞻性研究,我们将在 5 年内使用常见的标准化临床和神经生物学措施招募 800 例病例和 400 名适当对照。目的是收集足够大小和功效的样本,在大脑结构、电生理学、应激激素和基因组学的生物标志物领域,以及前驱表现和症状的临床领域,严格测试对精神病的责任和发展至关重要的元素。流行病学。修订后的提案解决了审稿人的担忧,包括将研究计划和措施纳入统一框架。这些发现将通过完善转变的预测因素并扩大我们对潜在神经机制的理解,增强我们识别即将发生精神病的高风险人群的能力。这些知识对于未来早期发现、干预和预防精神障碍的努力至关重要。公共卫生相关性:预防精神分裂症和其他精神病可以减轻个人和家庭痛苦以及社会经济损失的巨大负担。这个包含 8 个地点的项目旨在提高我们在发病前识别高风险个体的能力,并查明精神障碍出现背后的神经生物学变化。这些努力对于制定有效的精神障碍预防干预策略至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BARBARA A. CORNBLATT其他文献
BARBARA A. CORNBLATT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BARBARA A. CORNBLATT', 18)}}的其他基金
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
针对处理速度缺陷,改善临床精神病高风险青少年的社会功能并降低精神病风险
- 批准号:
10193909 - 财政年份:2021
- 资助金额:
$ 40.06万 - 项目类别:
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
针对处理速度缺陷,改善临床精神病高风险青少年的社会功能并降低精神病风险
- 批准号:
10193909 - 财政年份:2021
- 资助金额:
$ 40.06万 - 项目类别:
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
针对处理速度缺陷,改善临床精神病高风险青少年的社会功能并降低精神病风险
- 批准号:
10402865 - 财政年份:2021
- 资助金额:
$ 40.06万 - 项目类别:
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis
针对处理速度缺陷,改善临床精神病高风险青少年的社会功能并降低精神病风险
- 批准号:
10718302 - 财政年份:2021
- 资助金额:
$ 40.06万 - 项目类别:
2/3-Cognitive Behavioral Social Skills Training for Youth at Risk of Psychosis
2/3-针对患有精神病风险的青少年的认知行为社交技能培训
- 批准号:
8786233 - 财政年份:2014
- 资助金额:
$ 40.06万 - 项目类别:
2/3-Cognitive Behavioral Social Skills Training for Youth at Risk of Psychosis
2/3-针对患有精神病风险的青少年的认知行为社交技能培训
- 批准号:
8935921 - 财政年份:2014
- 资助金额:
$ 40.06万 - 项目类别:
Sensory processing deficits in the schizophrenia prodrome
精神分裂症前驱症状的感觉处理缺陷
- 批准号:
8105223 - 财政年份:2010
- 资助金额:
$ 40.06万 - 项目类别:
Clinical Assessment Strategies Unit (Research Methods Core)
临床评估策略单元(研究方法核心)
- 批准号:
8110771 - 财政年份:2010
- 资助金额:
$ 40.06万 - 项目类别:
4/8- Predictors & Mechanisms of Conversion to Psychosis
4/8- 预测
- 批准号:
8066006 - 财政年份:2008
- 资助金额:
$ 40.06万 - 项目类别:
相似国自然基金
青少年焦虑的预测和干预:基于跨通道恐惧泛化视角
- 批准号:32300928
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
推拿“舒筋调骨”干预青少年脊柱侧弯“肌肉力学-椎间载荷”平衡机制研究
- 批准号:82374607
- 批准年份:2023
- 资助金额:51 万元
- 项目类别:面上项目
基于数字表型青少年自杀行为转化风险测度及虚拟现实矫正干预研究
- 批准号:72304244
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
心肺耐力对青少年执行功能影响效应及其特定脑区激活状态的多民族研究
- 批准号:82373595
- 批准年份:2023
- 资助金额:47 万元
- 项目类别:面上项目
视屏活动和CaMKII m6A甲基化修饰影响青少年抑郁症状的纵向研究
- 批准号:82304168
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
Effects of tACS on alcohol-induced cognitive and neurochemical deficits
tACS 对酒精引起的认知和神经化学缺陷的影响
- 批准号:
10825849 - 财政年份:2024
- 资助金额:
$ 40.06万 - 项目类别:
Early Life Stress Induced Mechanisms of Cardiovascular Disease Risk and Resilience
生命早期压力诱发心血管疾病风险和恢复力的机制
- 批准号:
10555121 - 财政年份:2023
- 资助金额:
$ 40.06万 - 项目类别:
Neuromelanin MRI: A tool for non-invasive investigation of dopaminergic abnormalities in adolescent substance use.
神经黑色素 MRI:一种用于非侵入性调查青少年物质使用中多巴胺能异常的工具。
- 批准号:
10735465 - 财政年份:2023
- 资助金额:
$ 40.06万 - 项目类别:
Using policy codesign to achieve multi-sector alignment in adolescent behavioral health
利用政策协同设计实现青少年行为健康的多部门协调
- 批准号:
10724024 - 财政年份:2023
- 资助金额:
$ 40.06万 - 项目类别: