Tissue Engineering and Therapeutic Advances in Musculoskeletal Medicine

肌肉骨骼医学的组织工程和治疗进展

• 批准号: 7938714
• 负责人: J. Edward PUZAS
• 金额: $ 27.17万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938714
• 关键词: Applied Research; Appointment; Area; Award; Biomedical Engineering; Cell physiology; Center Core Grants; Degenerative polyarthritis; Development; Doctor of Philosophy; Engineering; Environment; Faculty; Fostering; Fracture Healing; Funding; Goals; Grant; Investigation; Knowledge; Laboratories; Learning; Medicine; Mentors; MicroRNAs; Musculoskeletal; Orthopedics; Osteoporosis; Pathology; Personnel Management; Polymers; Recruitment Activity; Regenerative Medicine; Repair Complex; Research; Research Infrastructure; Research Personnel; Research Project Grants; School Dentistry; Schools; Science; Scientist; Stem cells; Technology; Therapeutic; Tissue Engineering; Tissues; Translational Research; Universities; Work; Writing; adult stem cell; career; graft healing; interest; medical schools; novel; programs; scaffold; skills; square foot

DESCRIPTION (provided by applicant): This proposal seeks to support a research program in the area of tissue engineering in the musculoskeletal sciences. It is aimed at enriching the infrastructure of a translational research partnership at the University of Rochester. The partnership is between the Department of Orthopaedics and the Department of Biomedical Engineering and bridges the School of Medicine and School of Engineering and Applied Sciences. Operationally, the partnership combines the strengths and facilities of two departments dedicated to advancing knowledge for the genesis of neotissues that may be used in the treatment of musculoskeletal pathologies. The physical space for this research program combines the 18,000 square foot fully equipped laboratory of the Center for Musculoskeletal Research with the newly constructed 4-story research and office building (Goergen Hall) for the Department of Biomedical Engineering. The combined strengths of the Departments of Biomedical Engineering and Orthopaedics provide an outstanding environment for the development of academic research careers. Specialized programs in mentoring, grant writing, collaborative interactions and scientific technologies make this alliance a fruitful ground for launching and completing translational research programs. This application will use the ARRA P30 mechanism to seek funds to support a new recruit (Dr. Danielle Benoit) to the Departments of Biomedical Engineering and Orthopaedics. Dr. Benoit is a young scientist with outstanding potential that has been offered a tenure track faculty appointment in the Department of Biomedical Engineering (primary) and Orthopaedics (secondary). Her areas of research interest are related to the development of novel polymer scaffolds for musculoskeletal regenerative medicine and the use of micro RNA technology to control stem cell function in the repair of complex tissues. Both areas fit well with the goals of the Center for Musculoskeletal Research and the Department of Biomedical Engineering.

描述（由申请人提供）：该提案旨在支持肌肉骨骼科学组织工程领域的研究计划。它旨在丰富罗切斯特大学转化研究合作伙伴关系的基础设施。该合作伙伴关系是骨科系和生物医学工程系之间的合作关系，并将医学院和工程与应用科学学院联系起来。在运作上，该伙伴关系结合了两个部门的优势和设施，致力于推进可用于治疗肌肉骨骼疾病的新组织起源的知识。该研究项目的物理空间将肌肉骨骼研究中心 18,000 平方英尺设备齐全的实验室与生物医学工程系新建的 4 层研究和办公楼（格尔根大厅）结合在一起。生物医学工程系和骨科系的综合优势为学术研究事业的发展提供了良好的环境。指导、资助写作、协作互动和科学技术方面的专业项目使该联盟成为启动和完成转化研究项目的丰硕土壤。该申请将使用 ARRA P30 机制寻求资金来支持生物医学工程和骨科系的新员工（Danielle Benoit 博士）。 Benoit 博士是一位具有杰出潜力的年轻科学家，已获得生物医学工程（小学）和骨科（中学）系的终身教职。她的研究兴趣领域涉及用于肌肉骨骼再生医学的新型聚合物支架的开发以及使用微小RNA技术来控制复杂组织修复中的干细胞功能。这两个领域都非常符合肌肉骨骼研究中心和生物医学工程系的目标。