Harvard Older Americans Independence Center Grant

哈佛大学美国老年人独立中心拨款

• 批准号: 7935360
• 负责人: LEWIS LIPSITZ
• 金额: $ 20.56万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935360
• 关键词: ARHGEF5 gene; Address; Age; Aging; Ally; American; Angiotensins; Area; Award; Biological Markers; Biology; Biology of Aging; Blood Vessels; Cardiovascular system; Cause of Death; Cellular biology; Cerebrum; Clinical Research; Cognitive; Coronary heart disease; Development; Diabetic Angiopathies; Elderly; Ensure; Faculty; Fostering; Funding; Future; Gerontology; Goals; Grant; Heart failure; Image Analysis; Impaired cognition; Informatics; Institution; Intervention; Investigation; Knowledge; Leadership; Link; Measurement; Medicine; Mentors; Minority; Modeling; Obesity; Physical Function; Physiological; Physiology; Principal Investigator; Process; Proteomics; Psychometrics; Renin; Research; Research Methodology; Research Personnel; Research Training; Resources; Retinal; Risk Factors; Role; Scientist; Signal Transduction; Source; Stroke; Technology; Testing; Training; Training Programs; Translational Research; Vascular Diseases; age related; arm; cardiovascular risk factor; career development; cognitive function; cultural competence; design; disability; functional decline; functional loss; functional outcomes; improved; innovation; interest; meetings; member; multidisciplinary; new technology; outreach; precursor cell; professor; public health relevance; statistics

DESCRIPTION (provided by applicant): This is the second revision of our application to renew the Harvard Older Americans Independence Center (OAIC), which was previously funded by a P60 mechanism for 15 years. Over the past funding cycle our research has shown important relationships between cardiovascular risk factors, the development of cerebral and systemic microvascular disease, and the ultimate development of impaired cognitive and physical functions in older adults. Building on these observations, our renewal will focus on the vascular role In age related functional loss. The overarching goal of the new Harvard OAIC is to strengthen and expand our expertise, scientific resources, and translational research at the interface of vascular medicine and gerontology in order to enhance our understanding of the vascular role in age-related physical and cognitive functional decline, design new interventions to ameliorate this decline, and train new investigators to become skilled in this important area of research. To achieve this goal we are proposing a Research Career Development Core (RCDC) led by Drs. Edward Marcantonio and Murray Mittleman; a Pilot/Exploratory Studies Core (PESC) led by Drs. Douglas Kiel and Anthony Rosenzweig; a Leadership and Administration Core (LAC) led by Drs. Lewis Lipsitz and Peter Oettgen; and 3 Resource Cores, including: 1) Clinical Research and Recruitment, led by Dr. Lewis Lipsitz; 2) Advanced Statistics and Psychometrics led by Drs. Richard Jones and Adrienne Cupples; and 3) Physiologic Measurement and Biomarkers led by Dr. Vera Novak. For the RCDC, PESC, and LAC we have created leadership pairs who bring expertise in vascular biology, aging, and mentoring to our OAIC. Dr. Lipsitz Professor of Medicine and founding member of the Harvard OAIC, will continue to serve as principal investigator. After a formal solicitation and review process, we selected 3 RCD, 3 pilot, 2 small pilot, and 12 external projects for support. These are closely allied with our theme, have strong potential for future funding address knowledge gaps in our conceptual model, and bring new expertise to our Pepper Center in endothelial precursor cell biology, adipokine and obesity research, retinal vascular image analysis, endothelial function measurement, renin angiotensin physiology, proteomics, informatics, and nonlinear analysis of dynamic cardiovascular signals. The Harvard OAIC will bring faculty members together for research seminars, cultural competence training, and scientific suppers, and will foster the career development of a diverse group of new scientists who are dedicated to translational research in vascular aging. Our strong institutional commitments, outstanding faculty, extensive resources, and pipeline of talented trainees and junior faculty will help ensure we meet our goals. PUBLIC HEALTH RELEVANCE: Aging is one of the major risk factors for vascular diseases such as coronary heart disease, heart failure, and stroke, which are leading causes of death and disability in elderly people. The Harvard OAIC will strengthen and expand our knowledge and scientific resources in vascular medicine and aging to help us better understand the vascular role in age-related physical and cognitive decline, design new interventions to ameliorate this decline, and train new investigators to study this critical problem.

描述（由申请人提供）：这是我们续签哈佛老年人独立中心（OAIC）的申请的第二次修订，该中心先前由P60机制资助了15年。在过去的资金周期中，我们的研究表明心血管危险因素，大脑和全身微血管疾病的发展以及老年人认知和身体功能受损的最终发展之间的重要关系。在这些观察结果的基础上，我们的更新将集中在与年龄相关的功能损失中的血管作用上。新哈佛OAIC的总体目标是在血管医学和老年病的界面上增强和扩展我们的专业知识，科学资源和翻译研究，以增强我们对与年龄相关的物理和认知功能下降中血管作用的理解，并设计新的研究人员，以减轻这一新的研究者，并培训新的研究者，从而成为这一重要领域的研究人员。为了实现这一目标，我们提出了由DRS领导的研究职业发展核心（RCDC）。爱德华·马坎托尼奥（Edward Marcantonio）和默里·米特曼（Murray Mittleman）；由DRS领导的试点/探索性研究核心（PESC）。道格拉斯·基尔（Douglas Kiel）和安东尼·罗森茨威（Anthony Rosenzweig）；由Drs领导的领导力和管理核心（LAC）。 Lewis Lipsitz和Peter Oettgen；和3个资源核心，包括：1）由刘易斯·利普茨（Lewis Lipsitz）博士领导的临床研究和招聘； 2）由DRS领导的高级统计和精神计量学。理查德·琼斯（Richard Jones）和艾德里安（Adrienne Cupples）； 3）由Vera Novak博士领导的生理测量和生物标志物。对于RCDC，PESC和LAC，我们创建了领导对，他们为我们的OAIC带来了血管生物学，衰老和指导方面的专业知识。 Lipsitz博士医学教授和哈佛OAIC的创始成员将继续担任首席研究员。经过正式的招标和审查过程，我们选择了3个RCD，3个飞行员，2个小型飞行员和12个外部项目以进行支持。这些与我们的主题密切相关，具有强大的未来资金潜力解决我们的概念模型中的知识差距，并将新的专业知识带入我们的胡椒中心前体的前体细胞生物学，脂肪因子和肥胖研究，视网膜血管图像分析，内皮功能分析，内皮功能测量，肾素血管素的物理学，蛋白质学，蛋白质组学，蛋白质组学，非元素和非细胞分析。哈佛大学将将教职员工召集在一起，以进行研究研讨会，文化能力培训和科学晚餐，并将促进一群致力于在血管衰老中转化研究的新科学家的职业发展。我们强大的机构承诺，杰出的教职员工，丰富的资源以及有才华的学员和初级教师的管道将有助于确保我们实现我们的目标。 公共卫生相关性：衰老是血管疾病（例如冠心病，心力衰竭和中风）的主要危险因素之一，这是老年人死亡和残疾的主要原因。哈佛大学将加强和扩大我们在血管医学和衰老方面的知识和科学资源，以帮助我们更好地了解与年龄相关的身体和认知能力下降中的血管作用，设计新的干预措施以改善这种下降，并培训新的研究人员研究这个关键问题。