Harvard Older Americans Independence Center Grant

哈佛大学美国老年人独立中心拨款

• 批准号: 7935360
• 负责人: LEWIS LIPSITZ
• 金额: $ 20.56万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935360
• 关键词: ARHGEF5 gene; Address; Age; Aging; Ally; American; Angiotensins; Area; Award; Biological Markers; Biology; Biology of Aging; Blood Vessels; Cardiovascular system; Cause of Death; Cellular biology; Cerebrum; Clinical Research; Cognitive; Coronary heart disease; Development; Diabetic Angiopathies; Elderly; Ensure; Faculty; Fostering; Funding; Future; Gerontology; Goals; Grant; Heart failure; Image Analysis; Impaired cognition; Informatics; Institution; Intervention; Investigation; Knowledge; Leadership; Link; Measurement; Medicine; Mentors; Minority; Modeling; Obesity; Physical Function; Physiological; Physiology; Principal Investigator; Process; Proteomics; Psychometrics; Renin; Research; Research Methodology; Research Personnel; Research Training; Resources; Retinal; Risk Factors; Role; Scientist; Signal Transduction; Source; Stroke; Technology; Testing; Training; Training Programs; Translational Research; Vascular Diseases; age related; arm; cardiovascular risk factor; career development; cognitive function; cultural competence; design; disability; functional decline; functional loss; functional outcomes; improved; innovation; interest; meetings; member; multidisciplinary; new technology; outreach; precursor cell; professor; public health relevance; statistics

DESCRIPTION (provided by applicant): This is the second revision of our application to renew the Harvard Older Americans Independence Center (OAIC), which was previously funded by a P60 mechanism for 15 years. Over the past funding cycle our research has shown important relationships between cardiovascular risk factors, the development of cerebral and systemic microvascular disease, and the ultimate development of impaired cognitive and physical functions in older adults. Building on these observations, our renewal will focus on the vascular role In age related functional loss. The overarching goal of the new Harvard OAIC is to strengthen and expand our expertise, scientific resources, and translational research at the interface of vascular medicine and gerontology in order to enhance our understanding of the vascular role in age-related physical and cognitive functional decline, design new interventions to ameliorate this decline, and train new investigators to become skilled in this important area of research. To achieve this goal we are proposing a Research Career Development Core (RCDC) led by Drs. Edward Marcantonio and Murray Mittleman; a Pilot/Exploratory Studies Core (PESC) led by Drs. Douglas Kiel and Anthony Rosenzweig; a Leadership and Administration Core (LAC) led by Drs. Lewis Lipsitz and Peter Oettgen; and 3 Resource Cores, including: 1) Clinical Research and Recruitment, led by Dr. Lewis Lipsitz; 2) Advanced Statistics and Psychometrics led by Drs. Richard Jones and Adrienne Cupples; and 3) Physiologic Measurement and Biomarkers led by Dr. Vera Novak. For the RCDC, PESC, and LAC we have created leadership pairs who bring expertise in vascular biology, aging, and mentoring to our OAIC. Dr. Lipsitz Professor of Medicine and founding member of the Harvard OAIC, will continue to serve as principal investigator. After a formal solicitation and review process, we selected 3 RCD, 3 pilot, 2 small pilot, and 12 external projects for support. These are closely allied with our theme, have strong potential for future funding address knowledge gaps in our conceptual model, and bring new expertise to our Pepper Center in endothelial precursor cell biology, adipokine and obesity research, retinal vascular image analysis, endothelial function measurement, renin angiotensin physiology, proteomics, informatics, and nonlinear analysis of dynamic cardiovascular signals. The Harvard OAIC will bring faculty members together for research seminars, cultural competence training, and scientific suppers, and will foster the career development of a diverse group of new scientists who are dedicated to translational research in vascular aging. Our strong institutional commitments, outstanding faculty, extensive resources, and pipeline of talented trainees and junior faculty will help ensure we meet our goals. PUBLIC HEALTH RELEVANCE: Aging is one of the major risk factors for vascular diseases such as coronary heart disease, heart failure, and stroke, which are leading causes of death and disability in elderly people. The Harvard OAIC will strengthen and expand our knowledge and scientific resources in vascular medicine and aging to help us better understand the vascular role in age-related physical and cognitive decline, design new interventions to ameliorate this decline, and train new investigators to study this critical problem.

描述（由申请人提供）：这是我们更新哈佛美国老年人独立中心 (OAIC) 的申请的第二次修订，该中心之前由 P60 机制资助 15 年。在过去的资助周期中，我们的研究表明了心血管危险因素、脑和全身微血管疾病的发展以及老年人认知和身体功能受损的最终发展之间的重要关系。基于这些观察，我们的更新将重点关注血管在年龄相关功能丧失中的作用。新的哈佛 OAIC 的总体目标是加强和扩大我们在血管医学和老年学交叉领域的专业知识、科学资源和转化研究，以增强我们对血管在与年龄相关的身体和认知功能下降中的作用的理解，设计新的干预措施来改善这种下降，并培训新的研究人员熟练掌握这一重要的研究领域。为了实现这一目标，我们提议建立一个由 Drs. 领导的研究职业发展核心 (RCDC)。爱德华·马坎托尼奥和默里·米特曼；由博士领导的试点/探索性研究核心（PESC）道格拉斯·基尔和安东尼·罗森茨威格；由博士领导的领导和管理核心（LAC）刘易斯·利普西茨和彼得·奥特根； 3 个资源核心，包括： 1) 临床研究和招募，由 Lewis Lipsitz 博士领导； 2）由博士领导的高级统计和心理测量学。理查德·琼斯和艾德丽安·库普尔斯； 3) 由 Vera Novak 博士领导的生理测量和生物标志物。对于 RCDC、PESC 和 LAC，我们创建了领导对，他们为我们的 OAIC 带来血管生物学、衰老和指导方面的专业知识。哈佛 OAIC 的创始成员、医学教授 Lipsitz 博士将继续担任首席研究员。经过正式的征集和审查过程，我们选择了 3 个 RCD、3 个试点、2 个小型试点和 12 个外部项目进行支持。这些与我们的主题密切相关，具有强大的未来资助潜力，可解决我们概念模型中的知识差距，并为我们的 Pepper 中心带来内皮前体细胞生物学、脂肪因子和肥胖研究、视网膜血管图像分析、内皮功能测量、肾素血管紧张素生理学、蛋白质组学、信息学和动态心血管信号的非线性分析。哈佛 OAIC 将汇集教职员工参加研究研讨会、文化能力培训和科学晚宴，并将促进致力于血管衰老转化研究的多元化新科学家群体的职业发展。我们强有力的机构承诺、优秀的教师、广泛的资源以及才华横溢的学员和初级教师的渠道将有助于确保我们实现我们的目标。 公共卫生相关性：衰老是冠心病、心力衰竭和中风等血管疾病的主要危险因素之一，这些疾病是老年人死亡和残疾的主要原因。哈佛 OAIC 将加强和扩展我们在血管医学和衰老方面的知识和科学资源，帮助我们更好地了解血管在与年龄相关的身体和认知衰退中的作用，设计新的干预措施来改善这种衰退，并培训新的研究人员来研究这一关键疾病问题。