A National Resource for Postmortem Brain Research

国家死后脑研究资源

• 批准号: 8112554
• 负责人: FRANCINE M. BENES
• 金额: $ 148.38万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-17 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112554
• 关键词: Age; Alzheimer' s Disease; Autistic Disorder; Autopsy; Bipolar Disorder; Brain; Cessation of life; Chronic; Communities; Computer software; Data; Databases; Dementia; Deposition; Development; Diagnosis; Disease; Dissection; Drug or chemical Tissue Distribution; Dry Ice; Excision; Family; Family member; Freezing; Frontotemporal Dementia; Funding; Gender; Gene Expression Profiling; Goals; Home environment; Human; Huntington Disease; Image; Individual; Informed Consent; Institutionalization; Instruction; Liquid substance; Medical; Medical Records; Molecular; Molecular Biology; Movement Disorders; Neurosciences; Neurosciences Research; Nitrogen; Parkinson Disease; Parkinson' s Dementia; Pathologist; Patients; Pharmaceutical Preparations; Process; Psychotic Disorders; Public Domains; RNA; Reporting; Research; Research Personnel; Resources; Role; Schizophrenia; Services; Slide; Source; Specimen; Staging; Structure; Substance abuse problem; System; Tissue Sample; Tissues; Toxicology; Triplet Multiple Birth; base; brain research; brain tissue; cohort; demographics; flexibility; improved; indexing; interest; meetings; neurochemistry; neuropathology; operation; polysubstance abuse; repository; tissue resource; vapor; web site

DESCRIPTION (provided by applicant): The Harvard Brain Tissue Resource Center (HBTRC) is a national resource for the acquisition, processing, storage and distribution of high quality postmortem (PM) brain tissue to the neuroscience community. The HBTRC collects brains from individuals with a variety of movement disorders (Huntington's chorea and Parkinson's disease), dementias (Alzheimer's disease, frontotemporal dementias), major psychoses (schizophrenia and bipolar disorder) and autism. A key aspect of its functioning involves the acquisition of 70 normal controls representing a broad range of ages. During the current funding period, the HBTRC has continued its core value of maintaining the quality and efficiency of its operation. Each year, the HBTRC collects approximately 275-300 brains and distributes thousands of tissue samples to investigators in the U.S. and abroad. As a result of this effort, the HBTRC provides neuroscientists with well-characterized cohorts consisting of CONs and diseased brains matched for age, PMI, gender and hemisphere. Since almost all of our cases are obtained through community-based referrals, the potential confounding effects of institutionalization, inanition and substance abuse are minimized. To facilitate the donation and processing of brains, the HBTRC has a website with all the necessary forms including a) the Informed Consent for the donor families, b) instructions for handling brains by pathologists or dieners involved in removal, and c) application forms for investigators seeking tissue for their research. The HBTRC also has a User-Interactive Database, so that investigators who receive tissue from the "brain bank" can obtain critical information, such as demographics and neuropathology reports, as well as images of gross dissections and histological slides; To enhance the utility of our tissue, the HBTRC performs gene expression profiling on key regions of interest for each disorder and "deposits" this data in the National Brain Databank (NBD), a public domain repository from which investigators receiving tissue from the HBTRC can download this raw data. In turn, these investigators are encouraged to "deposit" their findings in the NBD so that colleagues studying the same disorder can use them for their respective studies. Over the next funding period, the HBTRC will continue its role as a vital national resource for the distribution of well-characterized, high quality tissue to the neuroscience community.

描述（由申请人提供）：哈佛大学脑组织资源中心（HBTRC）是用于对神经科学界的高质量后脑组织（PM）脑组织的获取，加工，存储和分配的国家资源。 HBTRC从患有多种运动障碍（亨廷顿的唱片和帕金森氏病），痴呆症（阿尔茨海默氏病，额叶痴呆症），主要精神病（精神分裂症和双相情感障碍）和自闭症的人那里收集大脑。其功能的一个关键方面涉及获得70个代表广泛年龄的正常对照。在当前的资金期间，HBTRC继续其核心价值，以保持其运营的质量和效率。每年，HBTRC收集大约275-300个大脑，并向美国和国外的研究人员分发数千个组织样本。由于这一努力，HBTRC为神经科学家提供了良好的人群，包括与年龄，PMI，性别和半球相匹配的缺点和患病的大脑。由于我们几乎所有的案件都是通过基于社区的转诊获得的，因此制度化的潜在混杂影响，侵害和滥用药物的可能性被最小化。为了促进大脑的捐赠和处理，HBTRC拥有一个网站，其中包括所有必要表格，包括a）捐助者家族的知情同意，b）涉及去除的病理学家或dieners处理大脑的指示，以及c）申请表的申请表格，用于寻求研究组织的调查人员。 HBTRC还具有一个用户相互作用的数据库，因此从“脑库”中接收组织的研究人员可以获取关键信息，例如人口统计学和神经病理学报告，以及剖析和组织学幻灯片的图像；为了增强组织的效用，HBTRC对每种疾病的关键区域进行基因表达分析，并“沉积”该数据在国家脑数据库（NBD）（NBD）中，这是一个公共领域存储库，研究人员从HBTRC中从HBTRC接收组织可以下载此原始数据。反过来，鼓励这些研究人员将其发现“沉积”到NBD中，以便研究同一疾病的同事可以将其用于各自的研究。在下一个资金期间，HBTRC将继续其作为向神经科学界分发出良好的高质量组织的重要国家资源。