A 1.5-T superconducting solenoid-dipole magnet for a magic-angle spinning field

用于魔角旋转场的 1.5T 超导螺线管偶极磁体

• 批准号: 8239103
• 负责人: Yukikazu Iwasa
• 金额: $ 64.73万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8239103
• 关键词: Adopted; Bathing; Data; Detection; Devices; Diagnosis; Disease; Drug toxicity; Ensure; France; Frequencies; Head; Health; Helium; Housing; Human; Laboratories; Liquid substance; Lung; Magic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Measures; Mechanics; Methods; Mission; Monitor; Nitrogen; Pacific Northwest; Phase; Predisposition; Public Health; Research; Research Personnel; Rotation; Science; Solid; Source; Staging; System; Temperature; Testing; Therapy Evaluation; Time; Tissues; Work; cold temperature; cryogenics; cryostat; design; disorder prevention; improved; innovation; metabolic abnormality assessment; novel; operation; programs; tool; vector

DESCRIPTION (provided by applicant): Phase 1 of this 2-phase program has two specific aims: 1) successful completion of a magic-angle-field (MAF) magnet of a significant field strength with an NMR-quality field homogeneity for slow MAS (magic-angle-spinning) MRI/NMR; and 2) application and demonstration with the proposed system of an innovative cryogenic system suitable for a superconducting magnet spinning in Phase 1 slowly (~0.1 Hz) and in Phase 2 at 6 Hz. Unlike a conventional NMR or MRI magnet that has a field vector of NMR quality directed only in one axis, an MAF vector may be decomposed into two field vectors, one directed in one axis and the other in the direction normal to the first axis. The best, and perhaps the easiest, way to ensure an NMR-quality field directed at an angle of 54.74o from the magnet axis (also the rotation axis) is to ensure independently an NMR-quality field generated by each of the coils comprising an MAF magnet. This is the crux of our innovative design concept to build a successful superconducting MAF magnet: a combination of an axial z-field solenoid coil and an x-axis field dipole coil, each generating an NMR-quality field of a specific strength. By adjusting each coil's field strength, we will be able to achieve with this Phase 1 magnet both requirements of field strength (here 1.5 T) and angle (54.74o). With this magnet, for the very first time, MAS NMR/MRI sciences will have a superconducting MAF magnet that generates an NMR- quality field of significant strength, e.g., 1.5 T >> 36 gauss (the previous high by the UC Berkeley group), operated in persistent mode. Another notable significance is an innovative cryogenics design applied to this magnet (also to used in Phase 2). Instead of operated in a bath of liquid helium (LHe), the magnet will be immersed in solid nitrogen (SN2). (In phase 2,the magnet will be housed in a cryostat which will rotate at 6 Hz.) This all-solid cold body ameliorates thermo-fluid issues associated with LHe under rotation. Also, the presence of SN2 in the cold body not only ensures a more uniform temperature throughout the windings but also provides a large thermal mass, enabling the magnet to maintain its operating field over a time period even when the primarily cooling source (LHe in Phase 1) is shut off. In summary, the successful completion of this 2-phase program will open new opportunities in MAS NMR/MRI sciences, which in turn will open new avenues to modern instrumental analysis, ultimately leading to novel non-invasive biomedical tools for analysis, diagnosis, and disease prevention. PUBLIC HEALTH RELEVANCE: Magnetic Resonance Imaging (MRI) together with localized Magnetic Resonance Spectroscopy (MRS) is a non-invasive method for studying metabolic changes associated with diseases, with applications to detection, diagnosis, monitoring the progress of therapy, and evaluation of drug toxicity. The proposed research is relevant to public health since it promises to extend the capabilities of MRI/MRS to tissues with highly inhomogeneous magnetic susceptibility, such as lung. It is relevant to NIH's mission since it leads directly to innovative research strategies with applications which will ultimately enhance and improve human health.

描述（由申请人提供）：该2相计划的第1阶段具有两个具体的目的：1）成功完成具有重要场强的魔法磁场（MAF）磁铁，具有NMR质量的田间同质性，用于缓慢的MAS（魔术 - 角旋转）MRI/NMR； 2）与提议的制度进行和演示，该系统适用于适合于阶段1（〜0.1 Hz）中的超导磁铁旋转的创新低温系统，在6 Hz时2阶段2中进行了旋转。与仅针对一个轴的NMR质量的野外向量的常规NMR或MRI磁铁不同，MAF矢量可以分解为两个磁场向量，一个针对一个轴，另一个针对另一个轴的方向，向第一轴正常。最好，也许是最简单的方法来确保从磁铁轴（也是旋转轴）以54.74O角度为54.74O的NMR质量场是确保由每个线圈组成MAF磁铁生成的NMR质量场。这是我们创新设计概念的关键，它可以建立成功的超导MAF磁铁：轴向Z线电磁螺线管和X轴偶极偶极线圈的组合，每个线圈都会产生特定强度的NMR质量场。通过调整每个线圈的场强度，我们将能够使用该阶段1磁铁的磁场强度（此处为1.5 T）和角度（54.74O）实现。使用此磁铁，MAS NMR/MRI科学将首次具有超导MAF磁铁，该磁铁会产生一个具有重要强度的NMR质量领域，例如1.5 T >> 36 Gauss（UC Berkeley Group的先前高高），以持久的模式运行。另一个值得注意的意义是应用于该磁铁的创新低温设计（也用于第2阶段）。磁铁将浸入固体氮（SN2）中。 （在第2阶段中，磁铁将容纳在低温恒温器中，该低温恒温器将以6 Hz的速度旋转。）这种全稳态的冷体可以改善与旋转旋转相关的热流体问题。同样，寒冷体内SN2的存在不仅可以确保整个绕组中的温度更加均匀，而且还提供了较大的热量，从而使磁铁能够在一段时间内维持其工作场，即使主要冷却源（第1阶段中的LHE）被关闭。总而言之，该2阶段计划的成功完成将为MAS NMR/MRI科学开放新的机会，这反过来又将为现代工具分析开辟新的途径，最终导致新型的非侵入性生物医学工具进行分析，诊断和预防疾病。 公共卫生相关性：磁共振成像（MRI）与局部磁共振光谱（MRS）是一种用于研究与疾病相关的代谢变化的非侵入性方法，以及用于检测，诊断，监测治疗进展和评估药物毒性的方法。拟议的研究与公共卫生有关，因为它有望将MRI/MRS的能力扩展到具有高度不均匀的磁敏感性（例如肺）的组织。它与NIH的使命相关，因为它直接导致了具有应用的创新研究策略，最终将改善和改善人类健康。