3D Functional Photoacoustic Imaging of Human Brain with a Stretchable Ultrasound Matrix Array

使用可拉伸超声矩阵阵列对人脑进行 3D 功能光声成像

• 批准号: 10252441
• 负责人: Yun Jing
• 金额: $ 86.74万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-05 至 2024-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252441
• 关键词: 3-Dimensional; Acoustics; Address; Adopted; Aging; Algorithms; Anatomy; Animal Model; Architecture; Bathing; Biological; Biological Markers; Brain; Brain imaging; Clinical; Cognitive; Coupling; Data; Detection; Development; Disease; Elements; Functional Imaging; Functional Magnetic Resonance Imaging; Geometry; Goals; Grant; Head; Heterogeneity; Human; Image; Imaging Techniques; Imaging technology; Ionizing radiation; Light; Methods; Modeling; Molecular Conformation; Motion; Near-Infrared Spectroscopy; Neurosciences Research; Operative Surgical Procedures; Optics; Penetration; Performance; Phase; Positioning Attribute; Process; Property; Research; Resolution; Scalp structure; Shapes; Signal Transduction; Speed; Stretching; Sulfur; Surface; System; Technology; Time; Tissues; Transducers; Ultrasonic Transducer; Ultrasonics; Ultrasonography; Water; X-Ray Computed Tomography; absorption; anatomic imaging; base; cost; cranium; design and construction; human imaging; human subject; image reconstruction; imaging approach; imaging capabilities; imaging modality; imaging system; improved; innovation; interest; molecular imaging; next generation; non-invasive imaging; nonhuman primate; novel; operation; optical fiber; optical imaging; optoacoustic tomography; photoacoustic imaging; reconstruction; response; sound; temporal measurement; translational neuroscience; two photon microscopy

Abstract Many scientific efforts have been devoted to understanding the brain functions, and the relevance of its dynamics during development, aging, and in diseased conditions. Alterations of the brain functions can result from multifactorial processes and be reflected by various biomarkers. The ability to quantify these changes at multiple scales will improve our understanding of brain anatomical and functional architectures, and the relations between these networks in both normal and diseased conditions. By virtue of the rich optical absorption contrast, high spatial and temporal resolutions, and relatively deep penetration, photoacoustic tomography (PAT) is a promising imaging modality that can address the limitations of functional magnetic resonance imaging (fMRI) and functional optical imaging for humans. There are major challenges associated with the skull that need to be addressed before PAT can be adopted to functional human brain imaging. The human skull severely distorts the photoacoustic (PA) signals, giving rise to suboptimal images. The standard approach to mitigate the distortion is to use CT-scans of the skull in concert with an image reconstruction method that considers the heterogeneity of the speed of sound. In addition, conventional ultrasound arrays are rigid and therefore cannot conform to the curvature of the skull. This creates a major challenge for efficient tissue-transducer coupling. Here, we propose to develop an ultrasound image- based approach for skull phase correction, which would eliminate the need of CT scans as well as image co- registration. To address the tissue-transducer coupling issue, we propose to use a stretchable matrix array that can seamlessly conform to the skull’s non-developable surface. Optical fibers will be integrated with the array to provide contact light delivery. The specific tasks to be completed during this grant period are: First, develop, fabricate, and characterize a 256-element stretchable sparse matrix array, second, numerically verify our phase correction and imaging algorithms, third, assess the array and algorithms experimentally using head-mimicking phantoms. At the end of this project we would have confirmed the performance of the stretchable matrix array and the accuracy of the phase correction and imaging algorithms. The preliminary results obtained from this proof-of- concept project will provide the basis upon which we can expand the size of the array and the number of elements to 1024. Such an array will offer a wide field of view for probing human brain functions and will be evaluated on human subjects.

抽象的 许多科学努力致力于了解大脑功能及其动态的相关性 在发育、衰老和疾病状态下，大脑功能可能会发生变化。 多因素过程并通过各种生物标志物反映的能力在多个方面量化这些变化。 量表将提高我们对大脑解剖和功能结构以及之间关系的理解 这些网络在正常和患病条件下都凭借丰富的光学吸收对比度，高。 光声断层扫描（PAT）具有空间和时间分辨率以及相对较深的穿透力，是一种很有前途的技术 可以解决功能性磁共振成像 (fMRI) 和功能性磁共振成像 (fMRI) 局限性的成像方式 人类光学成像。 在采用 PAT 之前，需要解决与头骨相关的重大挑战。 功能性人脑成像。人类头骨严重扭曲光声 (PA) 信号，从而产生 减轻失真的标准方法是同时使用头骨 CT 扫描。 采用考虑声速异质性的图像重建方法。 传统的超声波阵列是刚性的，因此无法符合头骨的曲率。 高效组织-传感器耦合的主要挑战在这里，我们建议开发超声图像- 基于颅骨相位校正的方法，这将消除 CT 扫描以及图像协同的需要 为了解决组织-传感器耦合问题，我们建议使用可拉伸矩阵阵列。 可以无缝地贴合头骨的不可展开表面 光纤将与阵列集成在一起。 提供接触式光传输。本次资助期间要完成的具体任务是：一是开发、 制造并表征 256 元素可拉伸稀疏矩阵阵列，其次，数值验证我们的相位 校正和成像算法，第三，评估阵列算法并使用模仿头部进行实验 幻影。 在这个项目结束时，我们将确认可拉伸矩阵阵列的性能和 从这个证明中获得的初步结果是相位校正和成像算法的准确性。 概念项目将为我们扩展数组的大小和元素的数量提供基础 到 1024。这样的阵列将为探测人脑功能提供广阔的视野，并将在 人类受试者。