Medical Instrument Compatible Disinfectant Generator

医疗器械兼容消毒剂发生器

基本信息

批准号：
7493579
负责人：
ANJAL C SHARMA
金额：
$ 44.95万
依托单位：
LYNNTECH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7493579
关键词：
Acetic Acid Acetic Acids Acids Address Aluminum Animals Award Back Bacteria Bacterial Spores Benign Biocide Biological Preservation Breathing Capital Caring Cells Chemicals Chlorine Citric Acid Collaborations Colonoscopes Communities Compatible Condition Construction Materials Consultations Corrosion Corrosives Cross Infection Custom Cyst Data Detection Development Devices Diagnostic Procedure Disinfectants Disinfection Dose Drops Drug Formulations Effectiveness Electrolyses Emerging Technologies Emulsions Endoscopes Environment Equilibrium Equipment Ethylene Oxide Evaluation Excision Exposure to Facility Construction Funding Category Food Foundations Frequencies Funding Gases Generations Germicide Glutaral Goals Government Health Health Professional High temperature of physical object Hospitals Hour Human Hydrocarbons Hydrogen Peroxide Hydrolysis Hypochlorite Hypochlorous Acid Hypochlorous Acids Hysteroscopes In Situ Industrial fungicide Industry Intervention Invasive Investments Irritants Joints Laparoscopes Legal patent Letters Licensing Life Liquid substance Maintenance Manufacturer Name Marketing Materials Testing Measures Medical Medical Device Medical center Medicine Membrane Metabolic Methods Microbe Microbial Biofilms Monitor Motivation Names Numbers Operating System Operative Surgical Procedures Oxidants Parents Patients Peracetic Acid Performance Peroxides Persons Phase Phase I Clinical Trials Poison Powder dose form Preparation Procedures Process Production Property Publications Purpose Range Rate Reproduction spores Research Research Personnel Resistance Safety Salts Sodium Chloride Sodium Hypochlorite Solutions Sterilization for infection control Sterilox Surgical Instruments System Techniques Technology Test Result Testing Texas Time Toxic effect Toxin Transportation Ultrasonics United States Environmental Protection Agency United States Food and Drug Administration Universities Virus Water Water Purification Work antimicrobial aqueous bacterial resistance bactericide base chlorine dioxide commercialization concept cost cost effective design desire detector direct application disease transmission dosage food preparation food sanitation fungus hazard inhibitor/antagonist innovation instrument interest killings medical food medical schools microbial microorganism new technology novel occupational hazard pressure prevent prototype skills sodium chlorite sodium sulfate success superoxidized water technology development trend user-friendly vapor virucide

项目摘要

DESCRIPTION (provided by applicant): Lynntech, Inc in collaboration with a reputed medical school proposes the development of an automated, on- demand, electrochemical generator of chlorine dioxide for a variety of high level disinfection applications, including endoscope reprocessing and surgical instrument disinfection. During the Phase I project, Lynntech has already demonstrated the construction and reliable operation of a bench scale automated device which can deliver desired levels of chlorine dioxide in a rapid manner. Lynntech's electrochemically generated chlorine dioxide solutions have been demonstrated to be as effective a disinfectant as commercially available presently used peracetic acid based high level disinfectants. In addition, Lynntech's electrochemically generated chlorine dioxide solutions have been shown to be compatible with a wide variety of medically relevant materials, and in certain cases, significantly less corrosive to medical materials than the widely used peracetic acid based disinfectants. Since complete proof-of-concept for Lynntech's automated electrochemical chlorine dioxide generator has been provided in the Phase I project, this proposed follow on Phase II effort specifically aims to develop a prototype compact device for automated medical device (endoscopes and surgical instruments) reprocessing. The device proposed herein will be fabricated, automated and tested upon retrofitting to a commercially available automated endoscope reprocessor for reliable operation in consultation with a reputed medical school. We will also perform exhaustive testing of the efficacy of the chlorine dioxide generator for low corrosion disinfection of actual surgical instruments and endoscopes during this Phase II effort. We will showcase our device and its operation to large manufacturers of automated endoscope reprocessors. Based on their input we will gear the technology to be commercially attractive to facilitate commercialization beyond Phase II in collaboration with these manufacturers, through either joint development, spin off company formation or outright licensing scenarios. The development of our low cost, fast acting and safe automated chlorine dioxide generator based automated reprocessor device will enable the production of high performance disinfecting solution for reliable medical instrument reprocessing. This will certainly reduce health professional exposure to toxic chemicals and decrease the cost of medical instrument reprocessing. In addition, the hundreds of thousands of patients who undergo endoscopic or surgical procedures annually will be adequately protected against cross infection through the availability of our automated medical instrument reprocessor. The financial benefits to existing automated reprocessing unit manufacturers who can simply modify their existing devices to incorporate the electrochemical chlorine dioxide production technology will therefore be immense.

描述（由申请人提供）：Lynntech, Inc 与一所知名医学院合作，提议开发一种自动化、按需、电化学二氧化氯发生器，用于各种高水平消毒应用，包括内窥镜再处理和手术器械消毒。在第一阶段项目中，Lynntech 已经展示了小型自动化设备的构造和可靠运行，该设备可以快速提供所需水平的二氧化氯。 Lynntech 的电化学产生的二氧化氯溶液已被证明是与市售目前使用的基于过乙酸的高水平消毒剂一样有效的消毒剂。此外，Lynntech 的电化学产生的二氧化氯溶液已被证明与多种医疗相关材料兼容，并且在某些情况下，对医疗材料的腐蚀性明显低于广泛使用的过氧乙酸消毒剂。由于第一阶段项目已经提供了 Lynntech 自动化电化学二氧化氯发生器的完整概念验证，因此拟议的第二阶段工作具体目标是开发用于自动化医疗设备（内窥镜和手术器械）再处理的原型紧凑设备。本文提出的装置将在改装为市售自动内窥镜清洗机后进行制造、自动化和测试，以便与知名医学院协商进行可靠操作。在第二阶段工作中，我们还将对二氧化氯发生器对实际手术器械和内窥镜进行低腐蚀消毒的功效进行详尽的测试。我们将向自动化内窥镜清洗机的大型制造商展示我们的设备及其操作。根据他们的意见，我们将与这些制造商合作，通过联合开发、分拆公司组建或直接许可方案，使该技术具有商业吸引力，以促进第二阶段之后的商业化。我们开发的低成本、快速作用且安全的基于自动二氧化氯发生器的自动再处理设备将能够生产用于可靠的医疗器械再处理的高性能消毒溶液。这肯定会减少卫生专业人员接触有毒化学品的机会，并降低医疗器械再处理的成本。此外，通过我们的自动化医疗器械再处理机，每年接受内窥镜或外科手术的数十万患者将得到充分保护，免受交叉感染。因此，现有的自动化后处理装置制造商可以简单地修改其现有设备以纳入电化学二氧化氯生产技术，从而获得巨大的经济效益。