2010 Mammary Gland Biology GRC

2010年乳腺生物学GRC

• 批准号: 8074052
• 负责人: D. Joseph Jerry
• 金额: $ 0.9万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8074052
• 关键词: Adopted; Affect; Biological; Biology; Breast Cancer Prevention; Breast Cancer Treatment; Cessation of life; Child; Collaborations; Developing Countries; Development; Environmental Exposure; Environmental Risk Factor; European; Fostering; Friendships; Funding; International; Lactation; Mammary gland; Nutritional; Pathway interactions; Postdoctoral Fellow; Prevention; Request for Proposals; Research; Research Personnel; Risk; Running; Site; Students; Time; Trust; United States National Institutes of Health; Woman; Work; cancer risk; expectation; falls; lifestyle factors; lifetime risk; malignant breast neoplasm; mammary gland development; meetings; multidisciplinary; public health relevance; social; success; symposium; unpublished works

DESCRIPTION (provided by applicant): This application seeks three years of funding support for the 23rd-25th Gordon Research Conference (GRC) on Mammary Gland Biology. This long-established conference is one of just a few annual meetings that falls into the "must-attend" class for mammary biologists and breast cancer researchers. The meeting aims to integrate research into the how the mechanisms underlying normal mammary gland development and environmental exposures contribute to both the risk and prevention of breast cancer as well as assuring competent lactation to meet the nutritional needs of children around the world. This multidisciplinary conference is the key meeting for the dissemination of findings that reveal the aberrant biological features of breast cancer by placing them into the context of normal function. The unique Gordon Conference format, where researchers share three meals per day and mandated social time over a working week, encourages the friendship and trust that very fosters both incisive discussions and the initiation of collaborative ventures. It is also the only meeting in this highly competitive field that maintains the tradition and expectation of revealing unpublished work. It also offers students and postdocs unprecedented access and exposure with a large number of slots reserved for presentations by this group. The international participation offers opportunities for unique perspectives and collaborations. For all of the reasons above, the demand for places at the Mammary Gland Biology GRC is high, as evidenced by the fact that it is one of the most popular conferences run by the GRC. To meet demand the GRC organization places this conference in their largest venues, and unlike most GRCs, the Mammary Gland Biology GRC is run every year, alternating between European and US sites fostering international collaborations. Even by adopting annual conferences, demand for the meeting routinely exceeds the limits placed on the conference by venue seating capacity. Further, the conference routinely receives high praise from its attendees when polled by the GRC organization, emphasizing the high value this conference provides to the attendees. The Mammary Gland Biology GRC has received unbroken NIH support for more than 6 years. This support has underpinned the success of the conference. To assure the continuity of its success, this proposal requests support for the next three conference years. PUBLIC HEALTH RELEVANCE: The lifetime risk of developing breast cancer is currently 1 in 8 among women in the U.S.A., with over 190,000 cases of invasive breast cancer and 40,000 deaths expected in 2009 alone. Though less frequent in developing countries the rates of breast cancer are rising at alarming rates underscoring the environmental and lifestyle factors that contribute to breast cancer. The Mammary Gland Biology Gordon Research Conference is an international conference dedicated to (i) understanding the developmental pathways that assure competent lactation to meet the nutritional needs of children around the world, (ii) how perturbations in developmental pathways and environmental exposures affect breast cancer risk and (iii) identify targets for prevention and treatment of breast cancer.

描述（由申请人提供）：本申请为第23届第25届戈登研究会议（GRC）提供了三年的资金支持。这次悠久的会议是乳腺生物学家和乳腺癌研究人员的“必不可少”课程中的几次年度会议之一。该会议旨在将研究的研究整合到正常乳腺发育和环境暴露的基础机制中如何有助于乳腺癌的风险和预防，并确保有能力的哺乳以满足世界各地儿童的营养需求。这次多学科会议是传播发现的关键会议，这些发现通过将乳腺癌的生物学特征置于正常功能的背景下，从而揭示了乳腺癌的异常生物学特征。 独特的戈登会议格式，研究人员每天共享三顿饭，并在一个工作周内要求社交时间，这鼓励了友谊和信任，这既促进了敏锐的讨论又促进了合作企业的启动。这也是这个高度竞争领域的唯一会议，以保持传统和期望揭示未出版的工作。它还为学生和博士后提供了前所未有的访问和曝光，并为该小组保留了大量的插槽。国际参与为独特的观点和合作提供了机会。 出于上述所有原因，对乳腺生物学GRC的地方的需求很高，这证明了这是GRC最受欢迎的会议之一。为了满足GRC组织的需求，该会议将本次会议放置在其最大的场所，与大多数GRC不同，乳腺生物学GRC每年都会运行，在促进国际合作的欧洲和美国站点之间交替。即使通过年度会议，对会议的需求通常超过场地座位容量在会议上的限制。此外，在由GRC组织进行民意调查时，会议通常会受到与会者的高度赞扬，这强调了这次会议向与会者提供的高价值。 乳腺生物学GRC已获得不间断的NIH支持已有6年以上。这项支持为会议的成功提供了支持。为了确保其成功的连续性，该提案要求支持未来三年的会议。 公共卫生相关性：美国妇女中目前患乳腺癌的终生风险目前为八分之一，仅在2009年就预计，有超过19万例侵入性乳腺癌和40,000例死亡。尽管发展中国家的频率较小，但乳腺癌的速度却增加了，这引起了促进乳腺癌的环境和生活方式因素的惊人速度。乳腺生物学戈登研究会议是一个国际会议，致力于（i）了解开发途径，以确保有能力哺乳以满足世界各地儿童的营养需求，（ii）发育途径和环境暴露的扰动如何影响乳腺癌的风险和（iii）对乳腺癌的预防和治疗靶标。