Trihalomethane Exposures in NHANES 1999-2001

1999-2001 年 NHANES 中的三卤甲烷暴露

基本信息

批准号：
8118629
负责人：
Nelson K Steenland
金额：
$ 7.67万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8118629
关键词：
Adult Age Air American Bathing Beverages Biological Markers Birth Blood Body Burden Body mass index CYP2E1 gene Centers for Disease Control and Prevention (U.S.)Characteristics Colorectal Data Data Analyses Data Set Detection Development Disinfection Environmental Health Enzymes Epidemiologic Studies Ethnic Origin Exposure to Fetal Growth Retardation Frequencies GSTT1 gene Goals Health Individual Intake Investigation Journals Laboratories Light Linear Regressions Malignant neoplasm of urinary bladder Manuscripts Measurement Modeling National Health and Nutrition Examination Survey Outcome Peer Review Population Predisposition Pregnancy Pregnant Women Premature Birth Public Health Public Health Schools Questionnaires Race Recommendation Regression Analysis Reporting Research Research Personnel Sampling Science Scientist Small for Gestational Age Infant Swimming Trihalomethanes United States National Center for Health Statistics Universities Water Woman Xenobiotics disorder prevention inhibitor/antagonist men public health relevance

项目摘要

DESCRIPTION (provided by investigator The 1999-2001 National Health and Nutrition Examination Survey (NHANES) included a special investigation on body burdens and major predictors among U.S. adults of exposure to trihalomethanes (THMs), toxic and carcinogenic by-products of water disinfection. The NHANES blood measurements show evidence of widespread exposure in the population, with detection frequencies ranging from 79- 98 percent for individual THMs. This is a national public health concern since epidemiologic studies show associations between long-term exposure to treated water (through, for example, showering/bathing, . swimming, and consuming hot beverages made with tap water) and certain cancers (bladder, colorectal) as well as adverse birth outcomes (preterm delivery, small for gestational age/intrauterine growth restriction). Our long-term goal is to elucidate the factors predicting inter-individual variability in blood THM levels. Our specific aims are to use the NHANES 1999-2001 data to investigate the influence of pregnancy status on the relationship between water and blood THM levels among U.S. women, and to investigate the influence of intake of common inducers/inhibitors of CYP2E1, GSTT1, CYPD6 and other THM-metabolizing enzymes on blood THM levels in U.S. women and men. We will construct multiple linear regression models to evaluate these relationships, controlling for tap water THM concentrations. Results of the proposed investigations could help inform the development of recommendations on lowering THM body burdens among susceptible individuals. PUBLIC HEALTH RELEVANCE: The majority of Americans have detectable levels of trihalomethanes, toxic and carcinogenic by- products of water disinfection, in their blood. We will analyze data from the special trihalomethane investigation of the 1999-2001 U.S. National Health and Nutrition Examination Survey to investigate the influence of pregnancy status and the intake of common inducers/inhibitors of CYP2E1, GSTT1, CYPD6 and other xenobiotic metabolizing enzymes on blood trihalomethane levels. Results of the proposed investigations could help inform the development of recommendations on lowering THM body burdens among susceptible individuals.

描述（由研究者提供的1999 - 2001年国家健康和营养检查调查（NHANES）包括对美国成年人暴露于三级甲烷（THMS）（THMS），有毒和致癌的副产品的特殊调查，并进行了79次曝光的证据。对于个人THM，这是一个全国性的公共健康问题，因为流行病学研究表明，长期接触经过的水（例如，通过淋浴/沐浴，。游泳，用自来水饮料制成的热饮料）预测血液THM水平的个体差异。我们将构建多个线性回归模型来评估这些关系，以控制自来水THM浓度。拟议的调查结果可以帮助告知有关降低易感人群的身体负担的建议。公共卫生相关性：大多数美国人在血液中具有可检测水平的三乙烷，有毒和致癌的副产品。我们将分析1999 - 2001年美国国家健康和营养检查调查的特殊三甲烷研究的数据，以研究妊娠状态的影响以及CYP2E1，GSTT1，CYPD6和其他异氧化胺分类酶对血液三氨基甲烷水平的普通诱导剂/抑制剂的摄入。拟议的调查结果可以帮助告知有关降低易感人群的身体负担的建议。