Clinical Retrovirology

临床逆转录病毒学

• 批准号: 8281554
• 负责人: Robert W. Coombs
• 金额: $ 31.59万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8281554
• 关键词: Acquired Immunodeficiency Syndrome; Adhesions; Adult; Advisory Committees; Anti-Retroviral Agents; Antibodies; Antigen-Antibody Complex; Antigens; Antiretroviral drug resistance; Antiviral resistance; Autologous; Biological Assay; Biostatistics Core; Blood; CCR5 gene; CD4 Positive T Lymphocytes; Cell Line; Cells; Centers for Disease Control and Prevention (U.S.); Cerebrospinal Fluid; Cervical; Clinical; Clinical Research; Clinical Trials Network; Computational Biology; Coombs' Test; DNA; DNA-Directed DNA Polymerase; Databases; Dementia; Detection; Development; Disease Progression; Disease regression; Doctor of Medicine; Doctor of Philosophy; Electronics; Epidemiology; Equipment; Evolution; Female; Genetic Polymorphism; Genital system; Genotype; Goals; Grant; HIV; HIV Core Protein p24; HIV Envelope Protein gp120; HIV Infections; HIV Vaccine Trials Network; HIV-1; HLA-DQ Antigens; Health Services Research; Health system; Host Defense; Immunobiology; Immunoblotting; Immunology; Infection; Institution; International; Irrigation; Laboratories; Ligation; Liquid substance; Lung; Maintenance; Malignant Neoplasms; Measurement; Medicine; Molecular; Molecular Immunology; Molecular Virology; Monitor; Mucositis; Mucous Membrane; Mycobacterium Infections; National Institute of Allergy and Infectious Disease; Oligonucleotides; Pathogenesis; Peer Review; Peer Review Grants; Peripheral Blood Mononuclear Cell; Plasma; Polymerase Chain Reaction; Population; Predisposition; Prevention; Prevention Research; Procedures; Process; Proteins; RNA; Recombinants; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Retrieval; Retrovirology; SIV; Saliva; Seminal fluid; Serodiagnoses; Services; Simplexvirus; Site; Social Behavior; Specimen; Surface; Techniques; Thymus Gland; Time; Tissues; Training Programs; Tropism; Umbilical Cord Blood; Universities; Vaccines; Variant; Viral; Viral Antigens; Virion; Washington; base; chemokine receptor; effective therapy; genital secretion; macrophage; mathematical model; pediatric AIDS; pol genes; professor; programs; quality assurance; rectal; repository; simian human immunodeficiency virus; transmission process; treatment strategy; vaccine development; virology

CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert W Coombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine & Medicine; Co-Director, Tuofu Zhu, M.D., Ph.D., Associate Professor, Department of Laboratory Medicine. SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED. The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational and interdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection by providing and developing HIV virology laboratory support and services for CFAR investigators. This purpose will be accomplished by providing virological markers of disease progression and regression and maintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, to serological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIV shedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virological laboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which are major themes of the UW CFAR proposal. The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratory include: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664; Al- 32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005); HIV-1 shedding, transmission and tropism (AI-38518; R21 pending); Evolution of HIV-1 variants in semen and blood (Al- 32885, AI-35539); Virological and host determinants of HIV-1 shedding in semen (DK-49477); Effect of female genital tract infection on HIV-1 shedding and evolution (HD40540); Effect of mucosal inflammation and HSV on HIV shedding (AI-4798; CFAR/CIPRA programs); Lymphoctye adhesion and HIV activation in the lung (RO1-HL083481); Mycobacterium infection and host defense (K08-HL03577); Pathogenesis of HIV env and vaccines (AI-47086; AI-065328; HD-38653); and HIV CNS infection and dementia (R21-MH63647).

CORE F - 华盛顿大学 CFAR 临床逆转录病毒学实验室核心。导演-Robert W Coombs，医学博士、博士、检验医学和医学系教授；联合主任朱托夫, 医学博士、博士、检验医学系副教授。 支持特定目的和关键科学项目。 临床逆转录病毒学实验室核心的具体目的是促进转化和 HIV感染的预防、发病机制和治疗的跨学科CFAR研究议程 为 CFAR 研究人员提供和开发 HIV 病毒学实验室支持和服务。这个目的 将通过提供疾病进展和消退的病毒学标记物来完成 与临床研究核心一起维护 CFAR 样本库。此外 HIV 血清学诊断、病毒分离、RNA 和 DMA 定量以及 HIV 检测程序 还可以利用 Core F 的特殊专业知识来检测粘膜表面的脱落情况。 实验室基础对于阐明艾滋病毒发病机制、疫苗和治疗策略具有重要意义， 华盛顿大学 CFAR 提案的主要主题。 临床逆转录病毒学核心实验室正在开展和目前支持的重点科研项目 包括：成人和儿童艾滋病临床试验网络的持续实验室支持（AI-27664；Al- 32910）、HIV 疫苗试验网络（AI-26503）和初次感染计划（AI-57005）； HIV-1 脱落， 传播和向性（AI-38518；R21 待定）；精液和血液中 HIV-1 变异体的进化（Al- 32885、AI-35539）；精液中 HIV-1 脱落的病毒学和宿主决定因素 (DK-49477)；效果 女性生殖道感染对 HIV-1 脱落和进化的影响 (HD40540)；粘膜炎症的影响 和 HSV 对 HIV 脱落的影响（AI-4798；CFAR/CIPRA 计划）；淋巴细胞粘附和 HIV 激活 肺（RO1-HL083481）；分枝杆菌感染和宿主防御（K08-HL03577）；艾滋病毒的发病机制 env 和疫苗（AI-47086；AI-065328；HD-38653）； HIV 中枢神经系统感染和痴呆 (R21-MH63647)。