CORE A: ADMINISTRATIVE CORE

核心 A：行政核心

• 批准号: 8360192
• 负责人: Naren R Vyavahare
• 金额: $ 22.34万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360192
• 关键词: Address; Advisory Committees; Area; Biocompatible Materials; Blood Vessels; Cells; Centers of Research Excellence; Committee Members; Complement; Core Facility; Cost Sharing; Coupling; Developmental Biology; Engineering; Funding; Goals; Grant; Health Care Costs; Histology; Human; In Vitro; Lasers; Medical; Medicine; Mentors; Molecular; Morbidity - disease rate; Muscle Cells; National Center for Research Resources; Nerve Regeneration; Pattern; Pilot Projects; Principal Investigator; Records; Recruitment Activity; Regenerative Medicine; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Source; South Carolina; Stem cells; Stroke; Surgeon; Technology; Testing; Tissue Engineering; Tissues; Training; United States National Institutes of Health; Universities; brain tissue; cellular imaging; clinically relevant; cost; economic cost; end-stage organ failure; functional restoration; mortality; skills; tissue regeneration; urologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary goal of this COBRE proposal is to increase the number of NIH-supported biomedical researchers in the state of South Carolina, particularly at Clemson University (CU). For this purpose, CU's unique strengths in biomaterials and tissue engineering will be complemented by expertise in medicine and developmental biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) to establish a Center of Biomaterials for Tissue Regeneration (CBTR) at CU. To accomplish the center's goal, an outstanding cadre of mentors mentor junior investigators toward independence as NIH-supported investigators. The center's tissue-regeneration theme simultaneously fits South Carolina's strength in regenerative medicine while addressing a significant cause of mortality and morbidity worldwide: End-stage organ failure and tissue loss create healthcare costs of nearly $400 billion annually in the US alone. Research in tissue regeneration offers the possibility of relief for these human and economic costs through restoration of functional tissues. The scientific focus of this center is regulation of tissue regeneration through cell biomaterials interactions. Five projects from junior investigators have been rigorously selected to fit this theme. These projects are 1) Stem cell-myocyte electrical coupling via a laser-patterned cell bridge; 2) Biomaterials for guided neural regeneration; 3) Understanding and Controlling Tissue-specific Vascular Patterning; 4) Mechanically guided urological tissue regeneration in vitro; and 5) Enabling Technology for Brain Tissue Regeneration after Stroke. Two pilot projects are also supported from cost share money. These target investigators are paired with mentors who are established, NIH-supported researchers with excellent track records in mentoring and with surgeons who will keep projects clinically relevant. The projects are supported by a well-organized infrastructure and three state-of-the-art core facilities (Materials Synthesis, Characterization and Testing, Histology and Imaging, and Cell and Molecular Engineering). Our nationally recognized External Advisory Committee members will critically evaluate the center's progress. This COBRE center will significantly augment collaborative efforts in South Carolina to recruit, train, and retain a critical mass of investigators with cross-disciplinary skills to collaborate effectively in the research area of regenerative medicine.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该杂种提案的主要目的是增加南卡罗来纳州，特别是在克莱姆森大学（CU）的NIH支持的生物医学研究人员的数量。为此，CU在生物材料和组织工程方面的独特优势将由南卡罗来纳州医科大学（MUSC）和南卡罗来纳大学（USC）建立生物材料组织再生（CBTR）生物材料中心的医学和发育生物学专业知识得到补充。为了实现该中心的目标，作为NIH支持的调查员，一位出色的导师导师少年调查员致力于独立。该中心的组织再生主题同时符合南卡罗来纳州的再生医学实力，同时解决了全球死亡率和发病率的重大原因：仅在美国，终末期器官衰竭和组织损失每年在美国就创造了近4000亿美元的医疗费用。组织再生的研究通过恢复功能组织为这些人类和经济成本提供了缓解的可能性。该中心的科学重点是通过细胞生物材料相互作用调节组织再生。严格选择了初级调查人员的五个项目以适合此主题。这些项目是1）通过激光图案的细胞桥进行干细胞肌细胞电耦合； 2）用于引导神经再生的生物材料； 3）理解和控制组织特异性血管图案； 4）体外机械引导的泌尿外科组织再生； 5）启用中风后脑组织再生的技术。成本共享资金也支持两个试点项目。这些目标研究人员与成立，由NIH支持的研究人员建立的导师配对，并具有出色的指导记录以及将保持临床相关项目的外科医生。这些项目得到了组织良好的基础设施和三个最先进的核心设施（材料合成，表征和测试，组织学和成像以及细胞和分子工程）的支持。我们全国认可的外部咨询委员会成员将对中心的进步进行严格评估。这个毛绒中心将大大增加南卡罗来纳州的合作努力，以招募，培训和保留大量的具有跨学科技能的调查员，以在再生医学研究领域有效地合作。