Drug Abuse Treatment Development and Research Mentoring

药物滥用治疗开发和研究指导

• 批准号: 8069902
• 负责人: Edward V. Nunes
• 金额: $ 17.47万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8069902
• 关键词: Abstinence; Academy; Adolescent; Adult; Age; Aggressive behavior; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; American; American Psychiatric Association; Anticonvulsants; Antidepressive Agents; Anxiety; Attention; Attention deficit hyperactivity disorder; Behavior Therapy; Behavioral; Biography; Biological; Biology; Biometry; Cannabis; Categories; Caucasians; Caucasoid Race; Cerebrum; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials Network; Cocaine; Cocaine Dependence; Cognitive; Cognitive Therapy; Cohort Studies; Collaborations; Combined Modality Therapy; Communities; Comorbidity; Confidence Intervals; DSM-III; DSM-IV; DSM-V; Data; Data Set; Depressed mood; Depression screen; Depressive Syndromes; Depressive disorder; Desipramine; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Disease; Dorsal; Dropout; Drug Addiction; Drug abuse; Drug usage; Early identification; Early treatment; Educational process of instructing; Effectiveness; Emotional; Evaluation; Faculty; Family; Feeling suicidal; Fellowship; Fellowship Program; First Degree Relative; Fluoxetine; Fostering; Free Will; Functional disorder; Funding; Future; Glucose; Goals; Guidelines; HIV; Heterogeneity; Image; Imipramine; Impairment; Inpatients; Intervention; Interview; Journals; K-Series Research Career Programs; Leadership; Link; Long Island; Maintenance; Major Depressive Disorder; Manuals; Marijuana Dependence; Measures; Medical Students; Memory; Mental Depression; Mental disorders; Mentors; Mentorship; Meta-Analysis; Metabolic; Metabolism; Methadone; Methods; Midcareer Investigator Award in Patient-Oriented Research; Mission; Modeling; Modification; Mood Disorders; Moods; Naltrexone; National Institute of Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Negative Reinforcements; Neurologic; Opiate Addiction; Opioid; Outcome; Outpatients; Pain; Paper; Parent-Child Relations; Parents; Pathological Gambling; Patient Self-Report; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Placebo Control; Placebo Effect; Plan B; Population; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Preventive Intervention; Process; Psychiatric Diagnosis; Psychiatry; Psychopathology; Publications; Published Comment; Recommendation; Recording of previous events; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Risk; Risk Factors; Risk Reduction; Sampling; Scanning; Schizophrenia; School-Age Population; Schools; Scientist; Screening procedure; Self Medication; Series; Serotonin; Sertraline; Source; Staging; Structure; Subgroup; Substance Addiction; Substance abuse problem; Substance-Related Disorders; Supervision; Symptoms; Syndrome; System; TNFRSF5 gene; Testing; Time; Toxic effect; Training; Trauma; Tricyclic Antidepressive Agents; Vertical Disease Transmission; Withdrawal; Woman; Work; addiction; alcohol seeking behavior; base; career; cingulate cortex; clinically significant; community based treatment; depressive symptoms; design; disorder later incidence prevention; early onset; effective therapy; effectiveness trial; experience; follow-up; high risk; improved; interest; mental disorder diagnosis; multi-site trial; nefazodone; neuropsychological; next generation; novel; outcome forecast; patient oriented research; placebo controlled study; prognostic; programs; psychosocial; research and development; skills; substance abuse treatment; symposium; theories; therapy development; treatment planning; treatment program; valproate

DESCRIPTION (provided by applicant): The goal of this K24 Mid-Career Clinician-Scientist proposal is to allow the Candidate, Dr. Edward Nunes, to continue to expand his program of research and research mentorship in the field of drug abuse treatment development. The Candidate's research program focuses on two related themes, the treatment of co-occurring psychopathology in substance dependent patients, and the development of combinations of behavioral and pharmacological treatments for drug dependence. Major activities and accomplishments have included a series of studies examining the efficacy of antidepressant medications for treatment of opioid, cocaine, and alcohol dependent patients with depression, projects applying advances in behavioral therapies to naltrexone maintenance for opioid dependence and to treatment of depression among methadone maintained patients, applications of behavioral therapy to enhance the design of cocaine medications development trials, and multi-site effectiveness trials in the NIDA Clinical Trials Network. Through collaborations and the work of colleagues Dr. Nunes has, and continues to mentor, his agenda has expanded to examine structured psychiatric diagnostic methods, HIV risk reduction, and other co-occurring psychopathology including attention deficit hyperactivity disorder, impulsive aggression, post-traumatic stress disorder, pathological gambling, neuropsychological functioning, and childhood psychopathology and risk for drug dependence. Over the course of the proposed K24 Dr. Nunes will serve as Principle Investigator on a Center Project, two R01s, and the Long Island Node of the Clinical Trials Network, and as Co-l, Sponsor, or Co-Sponsor on funded projects of junior colleagues and mentored K awards. In particular the K24 will free Dr. Nunes' time and provide resources to pursue the development of new initiatives and collaborations in treatment research and to create opportunities in patient-oriented research for junior colleagues. The mentoring plan will serve young investigators at three main levels, 1) junior faculty with early or emerging independent research programs many of whom Dr. Nunes has mentored since fellowship or during K awards, 2) three current K23 awardees for whom Dr. Nunes serves as Sponsor, and three current (or anticipated) K23 or K01 awardees for whom he serves as Co-Sponsor or Consultant, and 3) Post doctoral fellows in clinical research in the Department's NIDA funded T32 research fellowship program. In addition Dr. Nunes will seek to foster independent research initiatives and collaborations involving the clinical leadership of community-based treatment programs participating in the Clinical Trials Network. The ultimate goals are to improve the treatment of drug dependent patients through clinical research and to help foster the next generation of clinician-researchers.

描述（由申请人提供）：这项 K24 职业中期临床医生-科学家提案的目标是让候选人 Edward Nunes 博士继续扩大他在药物滥用治疗开发领域的研究计划和研究指导。该候选人的研究计划侧重于两个相关主题：物质依赖患者中同时发生的精神病理学的治疗，以及针对药物依赖的行为和药物治疗组合的开发。主要活动和成就包括一系列研究，检查抗抑郁药物治疗阿片类药物、可卡因和酒精依赖抑郁症患者的功效，项目将行为疗法的进展应用于维持阿片类药物依赖的纳曲酮以及治疗美沙酮中的抑郁症患者、应用行为疗法来增强可卡因药物开发试验的设计，以及 NIDA 临床试验网络中的多中心有效性试验。通过与同事的合作和工作，努内斯博士已经并将继续指导他的议程扩大到检查结构化精神病学诊断方法、降低艾滋病毒风险以及其他同时发生的精神病理学，包括注意力缺陷多动障碍、冲动攻击、创伤后应激障碍、病态赌博、神经心理功能、儿童精神病理学和药物依赖风险。在拟议的 K24 过程中，Nunes 博士将担任中心项目、两个 R01 和临床试验网络长岛节点的首席研究员，并担任以下资助项目的 Co-l、发起人或共同发起人：初级同事并指导 K 奖。特别是，K24 将释放 Nunes 博士的时间并提供资源，以推动治疗研究方面的新举措和合作的发展，并为初级同事创造以患者为导向的研究机会。该指导计划将为三个主要级别的年轻研究人员提供服务，1）拥有早期或新兴独立研究项目的初级教师，其中许多人是 Nunes 博士在获得奖学金后或在 K 奖期间所指导的；2）Nunes 博士所服务的三名当前 K23 获奖者作为发起人，以及由他担任共同发起人或顾问的三名当前（或预期）K23 或 K01 获奖者，以及 3）该部门 NIDA 临床研究的博士后研究员资助 T32 研究奖学金计划。此外，努内斯博士将寻求促进独立研究计划和合作，涉及参与临床试验网络的社区治疗项目的临床领导。最终目标是通过临床研究改善药物依赖患者的治疗，并帮助培养下一代临床医生研究人员。