RESEARCH CORE

研究核心

• 批准号: 7348273
• 负责人: Shafiq A Khan
• 金额: $ 11.37万
• 依托单位: CLARK ATLANTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-10-01 至 2012-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7348273
• 关键词: 1-Phosphatidylinositol 3-Kinase; Address; Advisory Committees; African American; Age; American; Androgens; Apoptosis; Applications Grants; Area; Arts; Biological; Biological Markers; Biology; Cancer Biology; Cancer Etiology; Caucasians; Caucasoid Race; Cell Proliferation; Cellular biology; Cessation of life; Chemistry; Clinical; Collaborations; Communities; Death Rate; Development; Diet; Disease; Disseminated Malignant Neoplasm; Economics; Environmental Risk Factor; Faculty; Genetic; Goals; Growth Factor; Hormones; Housing; Image; Immune; Immunity; Incidence; Individual; Inflammatory; Institution; Interleukin-10; Laboratories; Lead; Life Style; Malignant Neoplasms; Malignant neoplasm of prostate; Mentors; Metastatic Neoplasm to the Bone; Molecular Biology; Monitor; NCI Center for Cancer Research; Neoplasm Metastasis; Onset of illness; Pathway interactions; Phase; Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide; Pilot Projects; Protein Isoforms; Race; Rate; Reagent; Research; Research Activity; Research Personnel; Research Project Grants; Role; Sampling; Scientist; Signal Transduction; Skin Cancer; Snails; Stem Cell Factor; Sterols; Techniques; Therapeutic; Transforming Growth Factor beta; Universities; Week; Work; angiogenesis; anticancer research; base; cancer cell; chromatin remodeling; design; early onset; health disparity; instrumentation; member; men; mortality; programs; symposium; transcription factor

Prostate cancer is the second leading of cancer deaths among american men after skin cancer. In African- American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate due to this disease in African-American are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development at Clark Atlanta University is building a comprehensive research program to investigate the cellular and genetic factors involved in transformation, angiogenesis and metastasis of prostate cancer and how these factors may differ in African- American men. Three research projects in this grant application will investigate 1. Role of TGFbeta signaling during different phases of prostate cancer, 2. Impact of androgen regulated immune/inflammatory pathways in prostate cancers, and 3. The role of SNAIL transcription factor and TGFbeta in bone metastasis of prostate cancer cells. In addition, we are proposing six pilot projects which will focus on different aspects of prostate cancer biology such as: the role of IL-10 in prostate cancer immunity, c-kit ligand and signaling in metastatic cancer cells, role of PI3-kinase isoforms in prostate cancer, chromatin remodeling and its impact in prostate cancer cells, role of sterols in prostate cancer cell proliferation and apoptosis, and development of highly sensitive techniques to detect prostate cancer biomarkers. All investigators are housed in the same building and have access to state-of- the Art research core laboratories. These cores provide instrumentation and technical assistance in cell biology, molecular biology, and imaging. These facilites are managed by a Senior Research Scientist and a Facilites Coordinator. The reagents, clinical samples and materials generated for individual projects will be handled by the research core and will be shared by all investigators. The research projects from individual investigators are based on very interactive approaches and provide opportunities for collaborations among multiple investigators at the Center and scientists at several other institutions. The Pis of different projects and the research staff meets once a week to monitor and discuss the progress of individual projects and the scientific program of the center is overseen by external advisory committees with several members in the area of prostate cancer biology and chemistry.

前列腺癌是美国男性癌症死亡的第二大原因，仅次于皮肤癌。在非洲—— 美国男性前列腺癌发病率高出65%，死亡率高出一倍多 与白人男性相比。造成发病率和死亡率种族差异的原因 对非洲裔美国人的疾病知之甚少，但可能涉及生物和环境 因素。克拉克亚特兰大大学癌症研究和治疗开发中心 建立一个全面的研究计划来调查涉及的细胞和遗传因素 前列腺癌的转化、血管生成和转移以及这些因素在非洲人中的差异 美国男人。本拨款申请中的三个研究项目将调查 1. TGFbeta 信号传导的作用 前列腺癌不同阶段2.雄激素调节免疫/炎症通路的影响 3. SNAIL 转录因子和 TGFbeta 在前列腺癌骨转移中的作用 前列腺癌细胞。此外，我们还提出了六个试点项目，这些项目将侧重于不同方面 前列腺癌生物学，例如：IL-10 在前列腺癌免疫中的作用、c-kit 配体和信号传导 转移性癌细胞、PI3 激酶亚型在前列腺癌中的作用、染色质重塑及其影响 在前列腺癌细胞中，甾醇在前列腺癌细胞增殖和凋亡中的作用以及 检测前列腺癌生物标志物的高灵敏度技术。所有调查员都被安置在同一个房间 建设并使用最先进的研究核心实验室。这些核心提供仪器 以及细胞生物学、分子生物学和成像方面的技术援助。这些设施由 高级研究科学家和设施协调员。试剂、临床样本和材料 为各个项目生成的数据将由研究核心处理，并由所有研究人员共享。 个别研究人员的研究项目基于非常互动的方法，并提供 该中心的多名研究人员与其他几个机构的科学家之间进行合作的机会 机构。不同项目的PI和研究人员每周开会一次，进行监督和讨论 该中心的各个项目和科学计划的进展由外部顾问监督 由前列腺癌生物学和化学领域的多名成员组成的委员会。