Research Core

研究核心

• 批准号: 8544032
• 负责人: Shafiq A Khan
• 金额: $ 16.93万
• 依托单位: CLARK ATLANTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8544032
• 关键词: Advisory Committees; African American; Age; American; Androgens; Area; Basic Science; Bioinformatics; Biological; Biological Factors; Biomedical Research; Cancer Biology; Cancer Etiology; Caucasians; Caucasoid Race; Cellular biology; Cessation of life; Chemistry; Clinical; Collaborations; Communities; Contracts; Death Rate; Diet; Disease; Education; Environmental Risk Factor; Fostering; Genetic; Genomics; Goals; Healthcare; Histology; Housing; Human; Image; Immune; Incidence; Individual; Inflammatory; Institution; Instruction; Laboratories; Life Style; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical center; Metastatic Neoplasm to the Bone; Molecular Biology; Monitor; NCI Center for Cancer Research; Neoplasm Metastasis; Onset of illness; Pathway interactions; Personal Satisfaction; Phase; Positioning Attribute; Proteomics; Reagent; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Role; Sampling; Scientist; Services; Signal Transduction; Skin Cancer; Tissues; Transforming Growth Factor beta; Universities; Work; angiogenesis; anticancer research; base; cancer health disparity; design; health disparity; instrumentation; meetings; member; men; mortality; programs; repository; research and development; socioeconomics; structural biology; therapeutic development; transcription factor

PROJECT SUMMARY (See instructions): Prostate cancer is the second leading of cancer deaths among american men after skin cancer. In African- American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate in African Americans are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University is continuing to build a comprehensive research program to investigate the cellular and genetic factors involved in transformation, angiogenesis and metastasis of prostate cancer and how these factors may differ in African-American men. Three research projects in this renewal application will investigate 1) Role of TGFbeta signaling during different phases of prostate cancer, 2) Impact of androgen regulated immune/inflammatory pathways in prostate cancer, and 3) The role;of SNAIL transcription factor in prostate cancer bone metastasis. All investigators are housed in the same building and have access to state-of-the art research core laboratories. These cores provide instrumentation and technical assistance in cell biology/imaging, molecular biology, histology, proteomics, structural biology and bioinformatics, tissue repository and genomics. These facilities are managed by a Senior Research Scientist and a Facilities Coordinator. The reagents, clinical samples and materials generated for individual projects will be handled by the research core and will be shared by all investigators. The research projects from individual investigators are based on very interactive approaches and provide opportunities for collaborations among multiple investigators at CCRTD and scientists at several other institutions. The Pis of the different projects and the research staff meet once a week to monitor and discuss the progress of individual projects. The scientific program of the center is overseen by internal and external advisory committees with several members in the area of prostate cancer biology and chemistry.

项目摘要（参见说明）： 前列腺癌是美国男性癌症死亡的第二大原因，仅次于皮肤癌。与白人男性相比，非裔美国男性前列腺癌的发病率高出 65%，死亡率高出一倍多。非裔美国人发病率和死亡率存在种族差异的原因尚不清楚，但可能涉及生物和环境因素。克拉克亚特兰大大学癌症研究和治疗开发中心 (CCRTD) 正在继续建立一项综合研究计划，以调查参与前列腺癌转化、血管生成和转移的细胞和遗传因素，以及这些因素在非洲裔美国人中的差异。男人。本次更新申请中的三个研究项目将调查 1) TGFbeta 信号传导在前列腺癌不同阶段的作用，2) 雄激素调节的免疫/炎症途径对前列腺癌的影响，以及 3) SNAIL 转录因子在前列腺癌骨中的作用转移。所有研究人员都位于同一栋大楼内，并可以使用最先进的研究核心实验室。这些核心提供细胞生物学/成像、分子生物学、组织学、蛋白质组学、结构生物学和生物信息学、组织存储库和基因组学方面的仪器和技术援助。这些设施由一名高级研究科学家和一名设施协调员管理。各个项目产生的试剂、临床样本和材料将由研究核心处理，并由所有研究者共享。个别研究人员的研究项目基于高度互动的方法，为 CCRTD 的多名研究人员和其他几个机构的科学家之间的合作提供了机会。不同项目的 Pi 和研究人员每周举行一次会议，监督和讨论各个项目的进展。该中心的科学计划由内部和外部咨询委员会监督，该委员会有几名前列腺癌生物学和化学领域的成员。