Feasibility of In-vivo Determination of Absolute Elastic Tissue

绝对弹性组织体内测定的可行性

• 批准号: 7452150
• 负责人: TIMOTHY J HALL
• 金额: $ 24.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7452150
• 关键词: Acoustics; Algorithms; Biomechanics; Biopsy; Breast; Breast Cancer Detection; Breast Cancer Early Detection; Cations; Cities; Clinical; Clinical Trials; Condition; Data; Data Set; Detection; Development; Devices; Diagnosis; Differential Diagnosis; Disease; Early Diagnosis; Elastic Tissue; Elasticity; Environment; Facility Construction Funding Category; Feasibility Studies; Frequencies; Funding; Future; Goals; Histocompatibility Testing; Image; Imaging Phantoms; Imaging Techniques; In Vitro; Malignant Neoplasms; Mammary Gland Parenchyma; Measurement; Measures; Mechanics; Methods; Noninfiltrating Intraductal Carcinoma; Outcome; Patients; Performance; Phase I Clinical Trials; Probability; Property; Public Health; Radio; Range; Rate; Relative (related person); Research; Resolution; Sampling; Scanning; Schedule; Skin; Stress; Surface; System; Technology; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissue Sample; Tissues; Transducers; Ultrasonic Transducer; Ultrasonography; data acquisition; improved; in vivo; novel; outcome forecast; performance tests; pressure; reconstruction; research study; sensor; soft tissue; two-dimensional

DESCRIPTION (provided by applicant): The proposed research will investigate the feasibility of integrating a force sensor into a two-dimensional (2D) ultrasound transducer array for measuring the contact force during ultrasound elasticity imaging procedures. The contact force information will provide an absolute measure of the time at which contact is made with the skin surface and the total force applied at any point during scanning. That information will be used to calibrate (relative) mechanical strain images for comparing strain image contrast changes with increasing deformation and can be used for absolute elastic modulus reconstruction. Preliminary data demonstrate the potential gain from such a device. First, significant improvement in strain image quality is available when 3D tracking, enabled by a 2D array, is employed. Second, the elastic nonlinearity of various tissue types appears to be unique, and of potential significance, but a quantitative measure of the contact force is needed for an unbiased comparison of data. Third, recent results suggest it is possible to image the elastic nonlinearity parameter of breast tissues, and in vitro measurements of breast tissue samples found that ductal carcinoma in situ (DCIS) has the highest elastic nonlinearity. So, it might be possible to directly image the 3D distribution of DCIS in the breast. This could have a profound impact on breast cancer screening, early detection and treatment prognosis. The study involves a limited Phase I clinical trial to test performance of the combined imaging/force sensor device in a clinical environment. The subject pool for testing this technology will focus on patients with the highest probability of malignancy (i.e., BIRADS 4b or 4c) who are scheduled for ultrasound-guided biopsy. Feasibility of the device will be demonstrated if 2-D B-mode images are suitable for guiding clinical breast elastography, if the volume data acquisition rate is sufficiently fast to allow freehand elasticity imaging, if reliable, stable, force sensor measurements are obtained, and if the force sensor is robust, sensitive and has sufficient dynamic range to determine the initial contact with the skin surface and the total contact force during clinical breast imaging. If feasibility is demonstrated, future funding will be requested to optimize the combined transducer for a more comprehensive clinical trial of nonlinear breast elasticity imaging potentially targeting DCIS detection. PUBLIC HEALTH RELEVANCE: This is a proposal to study the feasibility of creating a two-dimensional ultrasound array transducer that has an integrated force sensor for detecting the contact force during elasticity imaging experiments. This transducer will enable clinically estimating the nonlinear mechanical properties of soft tissues and might eventually enable directly imaging ductal carcinoma in situ and thereby improve early detection of breast cancer.

描述（由申请人提供）：拟议的研究将调查将力传感器集成到二维（2D）超声换能器阵列中以测量超声弹性成像过程中的接触力的可行性。接触力信息将提供与皮肤表面接触的时间以及扫描期间任何点施加的总力的绝对测量值。该信息将用于校准（相对）机械应变图像，以比较应变图像对比度随变形增加的变化，并可用于绝对弹性模量重建。初步数据证明了这种设备的潜在收益。首先，当采用 2D 阵列支持的 3D 跟踪时，应变图像质量可以得到显着改善。其次，各种组织类型的弹性非线性似乎是独特的，并且具有潜在的意义，但是需要对接触力进行定量测量以进行数据的无偏比较。第三，最近的结果表明可以对乳腺组织的弹性非线性参数进行成像，并且对乳腺组织样本的体外测量发现导管原位癌（DCIS）具有最高的弹性非线性。因此，直接对乳腺 DCIS 的 3D 分布进行成像是可能的。这可能对乳腺癌筛查、早期检测和治疗预后产生深远影响。该研究涉及有限的一期临床试验，以测试组合成像/力传感器设备在临床环境中的性能。用于测试该技术的受试者池将重点关注计划进行超声引导活检的恶性肿瘤可能性最高的患者（即 BIRADS 4b 或 4c）。如果二维 B 模式图像适合指导临床乳腺弹性成像，如果体积数据采集速率足够快以允许徒手弹性成像，如果获得可靠、稳定的力传感器测量，并且如果力传感器坚固、灵敏并且具有足够的动态范围来确定临床乳腺成像期间与皮肤表面的初始接触和总接触力。如果可行性得到证实，未来将需要资金来优化组合传感器，以进行更全面的非线性乳腺弹性成像临床试验，可能针对 DCIS 检测。公共健康相关性：这是一项研究创建二维超声阵列换能器的可行性的提案，该换能器具有集成力传感器，用于检测弹性成像实验期间的接触力。该传感器将能够在临床上评估软组织的非线性机械特性，并最终可能能够直接对原位导管癌进行成像，从而改善乳腺癌的早期检测。