Dissecting Innate Immunity to Helminth Parasites

剖析对蠕虫寄生虫的先天免疫

基本信息

批准号：
8056629
负责人：
Mark Christopher Siracusa
金额：
$ 5.13万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-05 至 2013-03-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8056629
关键词：
Address Allergens Allergic Disease Antigen-Presenting Cells Antigens Asthma B Cell Proliferation B-Cell Activation B-Lymphocytes Basophils Bromodeoxyuridine CD4 Positive T Lymphocytes Cell Communication Cell Differentiation process Cell Line Cell physiology Cells Coculture Techniques Coupled Data Developed Countries Development Enzyme-Linked Immunosorbent Assay Exposure to Flow Cytometry Frequencies Gene Expression Profiling Goblet Cells Helminth Antigens Helminths Homing Hour Hyperplasia Hypersensitivity Immune Immune response Immunity Immunoglobulin Class Switching In Vitro Individual Infection Inflammation Inflammatory Response Injection of therapeutic agent Interleukin-13 Interleukin-4 Interleukin-5 Interleukin-9 Intestines Kinetics Laboratories Lymphocyte MHC Class II Genes Mediating Modeling Molecular Monitor Monoclonal Antibodies Mucous body substance Mus Natural Immunity Nematoda Parasites Pathway interactions Play Population Prevalence Production Proliferating Property Protocols documentation Recombinants Recruitment Activity Regulation Role STAT6 gene Schistosoma mansoni Signal Transduction Skin Smooth Muscle Soil Specific qualifier value Staining method Stains Stromal Cells Surface System TNFRSF5 gene TNFSF5 gene Testing Th2 Cells Time Trichuris Wound Healing base cell type chemokine chemokine receptor cytokine egg eosinophil human TSLP protein in vivo lymph nodes mouse model pandemic disease receptor response tool trafficking transcription factor

项目摘要

DESCRIPTION (provided by applicant): Th2 cytokine responses are required for immunity to helminth parasites and are also responsible for the detrimental inflammation associated with allergies and asthma. Given the global prevalence of soil transmitted helminth infections, currently estimated at two billion individuals worldwide, coupled with the pandemic of allergic diseases in industrialized countries, it is critical to gain a better understanding of the pathways that control Th2 cytokine-mediated immunity and inflammation. Despite significant developments in our understanding of the pathways that control the differentiation and regulation of Th2 immunity, the innate immune cells that recognize helminth- or allergen-derived antigens and present them to naive CD4+ T cells remain poorly defined. The aims of this proposal are directed at better understand those cells and mechanisms.

描述（由申请人提供）：TH2细胞因子反应是对蠕虫寄生虫的免疫力所必需的，并且还负责与过敏和哮喘有关的有害炎症。鉴于目前在全球范围内估计有20亿个人的土壤传播的蠕虫感染的全球流行率，再加上工业化国家的过敏性疾病的大流行，因此对控制TH2细胞因子介导的免疫和炎症的途径有更好的了解至关重要。尽管我们对控制Th2免疫分化和调节的途径的理解有了显着的发展，但识别嗜血率或过敏原衍生的抗原的先天免疫细胞，并将其呈现给天真的CD4+ T细胞的定义较差。该提案的目的是更好地理解这些细胞和机制。