NICHD Pelvic Floor Disorders Network Clinical Sites (U10)

NICHD 盆底疾病网络临床站点 (U10)

• 批准号: 8119835
• 负责人: JOSEPH I SCHAFFER
• 金额: $ 9.81万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119835
• 关键词: Address; Caring; Clinic; Clinical Protocols; Clinical Research; Clinical Trials Network; Collaborations; Colorectal Surgery; Estrogen Therapy; Faculty; Female; Hispanics; Hospitals; Housing; Manuscripts; Medical Indigency; Medical center; Medicine; Mission; National Institute of Child Health and Human Development; Nurse Practitioners; Operative Surgical Procedures; Organ; Patient Care; Patients; Pelvic Floor Disorders; Pelvis; Physical therapy; Physicians; Postoperative Period; Preparation; Prevention; Ptosis; Reconstructive Surgical Procedures; Recovery; Recurrence; Research; Scientist; Site; Techniques; Texas; Time; Universities; Urology; Woman; Work; biobank; clinical research site; control trial; experience; improved; patient population; randomized placebo controlled trial

DESCRIPTION (provided by applicant): This application describes the qualifications and experience of the Female Pelvic Medicine and Reconstructive Surgery (FPMRS) faculty and research teams at the University of Texas Southwestern Medical Center and Parkland Hospital and the facilities and patient population available to carry out clinical protocols sponsored by the Pelvic Floor Disorders Network (PFDN). UT Southwestern's Division of FPMRS includes 4 full-time faculty physicians, 1 full-time basic scientist and 4 full-time urogynecology nurse-practitioners. Additionally, the Departments of Urology, Colorectal Surgery and Physical Therapy care for many patients with pelvic floor disorders and maintain an active clinical and research collaboration with the Division of FPMRS. In 2009, there were 2160 women with pelvic floor disorders seen in the FPMRS clinics. Three hundred seventy eight women underwent surgical procedures for correction of pelvic floor disorders and 1782 women were managed with non-surgical techniques. The clinical research team described in this application has participated in the previous 5 year cycle of the PFDN and has had robust recruitment for every PFDN clinical trial. Our clinical and research clinics are targeted at both private patients (UT Southwestern) and medically indigent patients (Parkland Hospital). These clinics provide a diverse patient population which has allowed us to be the leading recruiter of Hispanic patients in the PFDN. Unique to our research team is an urogynecology basic and translational scientist. Through this collaboration, our site has led the effort to develop and implement the ABC Biorepository for the PFDN, which is now housed at UT Southwestern. In the last 5 year cycle we have been active in all aspects of the PFDN including concept proposal, committee participation and manuscript preparation. Importantly, the FPMRS physicians at UT Southwestern are philosophically dedicated to rigorous controlled trials intended to objectively evaluate principles of non-surgical and surgical care consistent with the mission of the PFDN. Included in this application is a concept proposal for a randomized placebo-controlled trial of intravaginal estrogen therapy as an adjunct to sacrocolpopexy for prevention of recurrent pelvic organ prolapse. We believe this trial builds on the previous work of the PFDN and addresses several key research topics including postoperative management to maximize recovery and minimize recurrence of pelvic floor disorders. We are of the view that this trial is ideally suited for the PFDN and has the potential to improve the care of patients with pelvic floor disorders.

描述（由申请人提供）：本申请描述了德克萨斯大学西南部医学中心和Parkland医院的女性骨盆医学和重建手术（FPMR）教师和研究团队的资格和经验，以及可用的设施和患者人群，以执行由Pelvic Floor Disorders网络（PFDN）进行的临床方案。 UT Southwestern的FPMR部门包括4位全日制教职员工，1名全职基础科学家和4位全日制泌尿妇女学护士。此外，许多骨盆底疾病患者的泌尿外科，结直肠手术和物理疗法护理部门，并与FPMR的部门保持了积极的临床和研究合作。 2009年，FPMRS诊所中有2160名骨盆底疾病的妇女。通过非手术技术，对三百七十8名妇女进行了矫正骨盆底部疾病和1782名妇女的手术程序。本应用程序中描述的临床研究小组参加了PFDN的前5年周期，并为每项PFDN临床试验都有强大的招聘。我们的临床和研究诊所针对私人患者（UT西南）和医学贫困患者（Parkland Hospital）。这些诊所提供了多样化的患者人群，使我们能够成为PFDN中西班牙裔患者的主要招聘人员。我们的研究团队独有的是泌尿妇女学基础和转化科学家。通过这项合作，我们的网站领导了为PFDN开发和实施ABC生物座席的努力，PFDN现在位于UT西南部。在过去的五年周期中，我们在PFDN的各个方面都积极活跃，包括概念建议，委员会参与和手稿准备。重要的是，UT西南部的FPMR医生是哲学上致力于严格的对照试验，旨在客观地评估与PFDN的任务一致的非手术和外科护理原则。 本应用中包括的是一项概念提案，用于对阴道雌激素治疗的随机安慰剂对照试验，作为预防复发性骨盆器官脱垂的sapocococolepopexy的辅助试验。我们认为，该试验基于PFDN的先前工作，并介绍了一些关键的研究主题，包括术后管理，以最大程度地恢复并最大程度地减少骨盆底疾病的复发。我们认为该试验非常适合PFDN，并且有可能改善骨盆底疾病患者的护理。