NICHD Pelvic Floor Disorders Network

NICHD 盆底疾病网络

• 批准号: 7161976
• 负责人: JOSEPH I SCHAFFER
• 金额: $ 23.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161976
• 关键词: birth; clinical research; clinical trials; cooperative study; experimental designs; fecal incontinence; female; female reproductive system disorder; human subject; human therapy evaluation; injury; medical outreach /case finding; muscle strength; outcomes research; patient oriented research; pelvis; postoperative complications; quality of life; rectum /anus; surgery; women' s health

DESCRIPTION (provided by applicant): This application describes the qualifications and experience of the urogynecology and urology faculty and research teams at the University of Texas Southwestern (UT Southwestern) Medical Center and Parkland Hospital and the facilities and patient population available to carry out clinical protocols sponsored by the Pelvic Floor Disorders Network. In 2004, there were more than 2,100 women with pelvic floor disorders seen in our clinics and 617 women underwent surgical procedures for correction of pelvic floor disorders. The Departments of Obstetrics and Gynecology and Urology have increasingly collaborated since 1997 to offer comprehensive care of women with pelvic floor disorders. In addition to urogynecology and urology, collaboration includes faculty from colorectal surgery, radiology, physical therapy, and maternal-fetal medicine. The clinical research teams described in this application have successful prior as well as on-going experience in NIH sponsored national multi-center trials. Centerpieces in this application are two existing research clinics, one targeted at private patients (operated by the Urology Department) and the other focused on medically indigent patients (operated by the Obstetrics and Gynecology Department). Also included in this application is a concept application for a randomized trial designed to assess the efficacy of end-to-end versus overlapping repair of the external anal sphincter lacerated during childbirth. The primary outcome is anal incontinence which is a significant consequence of such lacerations. This trial would permit accurate evaluation of the outcome of specific surgical procedures which is one of the prime areas of interest leading to creation of the Pelvic Floor Disorders Network. We are of the view that along with strategies for prevention of anal sphincter laceration during childbirth, optimal management of the torn sphincter should also be studied since more than 200,000 women sustain such pelvic floor injuries each year in the United States.

描述（由申请人提供）：本申请描述了德克萨斯大学西南大学（UT Southwestern）医疗中心和Parkland医院的泌尿妇女学和泌尿外科教师和研究团队的资格和经验，以及可用于执行Pelvicloes障碍网络发起的临床方案的设施和患者人群。 2004年，我们的诊所中有2100多名骨盆底疾病的女性，有617名妇女接受了骨盆底疾病的手术程序。自1997年以来，妇产科和泌尿科的妇产科和泌尿科部门越来越多地合作，为患有骨盆底疾病的妇女提供全面的护理。除了泌尿疗法和泌尿外科外，合作还包括结肠直肠外科，放射学，物理疗法和孕产妇医学的教师。该应用程序中描述的临床研究团队在NIH赞助的国家多中心试验中都具有成功的事先和持续的经验。该应用程序中的核心是两个现有的研究诊所，一个针对私人患者（由泌尿外科部门运营），另一个针对医学贫穷的患者（由妇产科和妇科部门运营）。此应用程序还包括一个概念应用程序，用于一项随机试验，旨在评估端到端的效果与分娩过程中外部肛门括约肌的重叠修复的功效。主要结果是肛门尿失禁，这是这种撕裂的重要结果。该试验将允许对特定手术程序的结果进行准确的评估，这是引起骨盆底部疾病网络的主要关注领域之一。我们认为，还应研究分娩期间预防肛门括约肌裂缝的策略，还应研究对括号内撕裂的最佳管理，因为在美国，超过20万名女性每年会承受这种骨盆底损伤。