ROLE OF LEUKOTRIENE B4 METABOLISM IN SEVERE ASTHMA

白三烯 B4 代谢在严重哮喘中的作用

• 批准号: 7375111
• 负责人: ELIZABETH R JACOBS
• 金额: $ 0.06万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375111
• 关键词: ROLE; LEUKOTRIENE; B4; METABOLISM; SEVERE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study examines the potential contribution of CYP4F3 to clinical asthma. 40 patients with severe or persistent asthma will be recruited from the Asthma and Obstructive Disease clinics, while 40 controls will be recruited from the community at large. Blood will be drawn for genetics and evaluation of leukotriene metabolism, and the exhaled breath condensate will be collected for evaluation of NO and leukotriene levels, as well as IgE and RAST testing. In addition, the control subjects will complete a questionnaire and undergo spirometry testing. The patients will receive 4-6 months of clinical, educational, physiological, and pharmacological assessment and optimization, including high doses of inhaled corticosterones and long-acting inhaled beta-agonists to minimize symptoms and optimize lung function, after which they will again visit the GCRC for blood and exhale breath condensate testing. During the outpatient GCRC visits, nursing staff will be asked to administer the questionnaire, obtain informed consent, and draw and process blood samples. Biostatistics support is also requested to assist with the analysis of sample power.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。本研究探讨了 CYP4F3 对临床哮喘的潜在贡献。将从哮喘和阻塞性疾病诊所招募 40 名患有严重或持续性哮喘的患者，同时将从整个社区招募 40 名对照者。抽血用于遗传学和白三烯代谢评估，并收集呼出气冷凝物用于评估 NO 和白三烯水平以及 IgE 和 RAST 测试。此外，对照受试者将完成一份调查问卷并接受肺活量测定测试。患者将接受4-6个月的临床、教育、生理和药理学评估和优化，包括高剂量吸入皮质酮和长效吸入β受体激动剂，以尽量减少症状并优化肺功能，之后他们将再次就诊GCRC 用于血液和呼出气体冷凝物测试。在门诊 GCRC 就诊期间，护理人员将被要求填写调查问卷、获得知情同意、抽取和处理血样。还需要生物统计学支持来协助样本功效分析。