INDUCED SPUTUM TO EVALUATE ANTI-INFLAMMATORY AGENTS IN CF PATIENTS

诱导痰法评估 CF 患者的抗炎药物

• 批准号: 7377032
• 负责人: RICHARD C AHRENS
• 金额: $ 1.39万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377032
• 关键词: INDUCED; SPUTUM; EVALUATE; ANTI; INFLAMMATORY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammation clearly contributes to the progression of cystic fibrosis (CF) lung disease. Anti-inflammatory therapy with alternative-day corticosteroids and twice-daily high-dose ibuprofen in patients with CF has shown clinical benefit. However, this therapy probably does not improve lung function as much as it slows the rate of decline in lung function. This poses certain constraints on the design of trials to test new anti-inflammatory agents, especially as it pertains to selection of efficacy outcome parameters. The hypothesis is that ibuprofen and celecoxib will reduce neutrophils, active elastase, and pro-inflammatory cytokines in induced sputum after 4 weeks of therapy in patients with CF. The specific aim of this study is to determine whether neutrophils, active elastase, and cytokines measured in sputum induced by using hypertonic saline are useful screening tests for determining if a particular agent with known anti-inflammatory properties is a suitable candidate for further clinical trials in CF subjects. This aim will be addressed using one anti-inflammatory agent, ibuprofen, that has been shown to have clinical benefit in CF, and one anti-inflammatory agent, celecoxib, that has potential to have clinical benefit in CF. A "no treatment" arm will be included as the control group.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。炎症显然会导致囊性纤维化（CF）肺病的进展。对 CF 患者使用隔日皮质类固醇和每日两次大剂量布洛芬进行抗炎治疗已显示出临床益处。然而，这种疗法可能并不能改善肺功能，而是可以减缓肺功能下降的速度。这对测试新抗炎药物的试验设计造成了一定的限制，特别是在疗效结果参数的选择方面。假设布洛芬和塞来昔布在 CF 患者治疗 4 周后会减少诱导痰中的中性粒细胞、活性弹性蛋白酶和促炎细胞因子。本研究的具体目的是确定使用高渗盐水诱导的痰中测量的中性粒细胞、活性弹性蛋白酶和细胞因子是否是有用的筛选试验，以确定具有已知抗炎特性的特定药物是否适合进行进一步的临床试验。 CF 科目。这一目标将通过使用一种抗炎药布洛芬和一种抗炎药塞来昔布来实现，布洛芬已被证明对 CF 具有临床益处，而塞来昔布可能对 CF 具有临床益处。 “未治疗”组将被纳入作为对照组。