Core-A Administative

核心A行政管理

• 批准号: 8105266
• 负责人: David A Lewis
• 金额: $ 11.78万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105266
• 关键词: Address; Arts; Biological Markers; Clinical; Clinical Research; Clinical Services; Communities; Development; Diagnostic; Disease; Environment; Functional disorder; Human; Imaging Device; In Vitro; Individual; Intervention; Knowledge; Link; Mental disorders; Methods; Molecular; Molecular Abnormality; Monitor; Neurons; Neurosciences; Pathology; Pattern; Positron-Emission Tomography; Process; Research; Research Activity; Research Personnel; Role; Schizophrenia; Science; Syndrome; Testing; Training; Universities; base; career development; cell type; cognitive system; data management; gamma-Aminobutyric Acid; improved; in vivo; information processing; knowledge base; medical schools; neurotransmission; nonhuman primate; novel therapeutic intervention; statistics; synergism; translational approach; translational study

This Conte Center for the Neuroscience of Mental Disorders (CCNMD) offers a highly interactive scientific environment that integrates the basic and clinical research activities of multiple investigators from the University of Pittsburgh's Schools of Medicine and Arts and Sciences and the adjacent Carnegie Mellon University. Collectively, the CCNMD represents a broad array of expertise spanning molecular, systems, cognitive, computational and clinical neuroscience that provides complementary approaches to testing the central hypothesis that a distinctive pattern of molecular alterations in subpopulations of GABA neurons (pathology) gives rise to conserved disturbances in cortical network oscillations (pathophysiology) that underlie the core information processing deficits (clinical syndrome) of schizophrenia. The proposed 5 projects, supported by Administrative, Clinical Services and Diagnostics, and Statistics and Data Management Cores, examine 1) molecular abnormalities in schizophrenia in distinct subsets of cortical GABA neurons thought to generate oscillatory activity (Project 1-Lewis); 2) integrated computational, electrophysiological and anatomical approaches to determine the relationship between cell type-specific cortical GABA neurotransmission and oscillations in vitro (Project 2-Ermentrout); 3) the role of GABA neurotransmission in cortical oscillations elicited by tasks that tap in non-human primates the same information processing domains that are altered in schizophrenia (Project 3-Olson); 4) specific types of information processing disturbances in schizophrenia that are linked to altered activation of, and impaired network oscillations in, certain cortical regions (Project 4-Phillips); and 5) the development of new PET imaging tools for studying the function of human cortical GABA neurons in vivo (Project 5-Mathis). The synergism and bi-directional interactions of these projects facilitates a translational approach to schizophrenia research directing at identifying pathophysiology-based targets for novel therapeutic interventions and developing biomarkers of the pathophysiology that can be used to monitor the efficacy of such interventions. Thus, the proposed Center is a multi-disciplinary effort directed at testing a mechanistic hypothesis in order to improve our understanding of a core component of the disease process of schizophrenia. In addition, the Center provides 1) a rich environment for training and career development in which individuals can become involved in studies that bring the methods and knowledge base of basic neuroscience to address critical questions in clinical schizophrenia research, and 2) a mechanism for disseminating the importance of, and the knowledge gained from, translational studies of schizophrenia to the broader scientific and lay communities.

该康特精神障碍神经科学中心 (CCNMD) 提供高度互动的科学 整合来自多个研究人员的基础和临床研究活动的环境 匹兹堡大学医学院、艺术与科学学院以及邻近的卡内基梅隆大学 大学。总的来说，CCNMD 代表了涵盖分子、系统、 认知、计算和临床神经科学提供了测试的补充方法 中心假设是 GABA 神经元亚群中分子改变的独特模式 （病理学）引起皮质网络振荡的保守性干扰（病理生理学） 是精神分裂症核心信息处理缺陷（临床综合征）的基础。拟议的 5 项目由行政、临床服务和诊断以及统计和数据支持 管理核心，检查 1) 精神分裂症不同皮质亚群的分子异常 GABA 神经元被认为会产生振荡活动（项目 1-Lewis）； 2）综合计算， 电生理学和解剖学方法来确定细胞类型特异性之间的关系 体外皮质 GABA 神经传递和振荡（项目 2-Ermentrout）； 3）GABA的作用 在非人类灵长类动物中进行同样的任务所引发的皮质振荡中的神经传递 精神分裂症中改变的信息处理域（项目 3-Olson）； 4）具体类型 精神分裂症的信息处理障碍与激活改变和受损有关 某些皮质区域的网络振荡（Project 4-Phillips）； 5）新型PET的开发 用于研究体内人类皮质 GABA 神经元功能的成像工具（项目 5-Mathis）。这 这些项目的协同作用和双向互动促进了转化方法 精神分裂症研究旨在确定基于病理生理学的新治疗目标 干预措施和开发可用于监测疗效的病理生理学生物标志物 此类干预措施。因此，拟议的中心是一个多学科的努力，旨在测试机械 假说，以提高我们对疾病过程核心组成部分的理解 精神分裂症。此外，中心还提供：1）丰富的培训和职业发展环境 哪些人可以参与带来基本方法和知识基础的研究 神经科学解决临床精神分裂症研究中的关键问题，以及 2) 一种机制 传播精神分裂症转化研究的重要性以及从中获得的知识 更广泛的科学界和非专业界。