Core-A Administative

核心A行政管理

• 批准号: 8105266
• 负责人: David A Lewis
• 金额: $ 11.78万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8105266
• 关键词: Address; Arts; Biological Markers; Clinical; Clinical Research; Clinical Services; Communities; Development; Diagnostic; Disease; Environment; Functional disorder; Human; Imaging Device; In Vitro; Individual; Intervention; Knowledge; Link; Mental disorders; Methods; Molecular; Molecular Abnormality; Monitor; Neurons; Neurosciences; Pathology; Pattern; Positron-Emission Tomography; Process; Research; Research Activity; Research Personnel; Role; Schizophrenia; Science; Syndrome; Testing; Training; Universities; base; career development; cell type; cognitive system; data management; gamma-Aminobutyric Acid; improved; in vivo; information processing; knowledge base; medical schools; neurotransmission; nonhuman primate; novel therapeutic intervention; statistics; synergism; translational approach; translational study

This Conte Center for the Neuroscience of Mental Disorders (CCNMD) offers a highly interactive scientific environment that integrates the basic and clinical research activities of multiple investigators from the University of Pittsburgh's Schools of Medicine and Arts and Sciences and the adjacent Carnegie Mellon University. Collectively, the CCNMD represents a broad array of expertise spanning molecular, systems, cognitive, computational and clinical neuroscience that provides complementary approaches to testing the central hypothesis that a distinctive pattern of molecular alterations in subpopulations of GABA neurons (pathology) gives rise to conserved disturbances in cortical network oscillations (pathophysiology) that underlie the core information processing deficits (clinical syndrome) of schizophrenia. The proposed 5 projects, supported by Administrative, Clinical Services and Diagnostics, and Statistics and Data Management Cores, examine 1) molecular abnormalities in schizophrenia in distinct subsets of cortical GABA neurons thought to generate oscillatory activity (Project 1-Lewis); 2) integrated computational, electrophysiological and anatomical approaches to determine the relationship between cell type-specific cortical GABA neurotransmission and oscillations in vitro (Project 2-Ermentrout); 3) the role of GABA neurotransmission in cortical oscillations elicited by tasks that tap in non-human primates the same information processing domains that are altered in schizophrenia (Project 3-Olson); 4) specific types of information processing disturbances in schizophrenia that are linked to altered activation of, and impaired network oscillations in, certain cortical regions (Project 4-Phillips); and 5) the development of new PET imaging tools for studying the function of human cortical GABA neurons in vivo (Project 5-Mathis). The synergism and bi-directional interactions of these projects facilitates a translational approach to schizophrenia research directing at identifying pathophysiology-based targets for novel therapeutic interventions and developing biomarkers of the pathophysiology that can be used to monitor the efficacy of such interventions. Thus, the proposed Center is a multi-disciplinary effort directed at testing a mechanistic hypothesis in order to improve our understanding of a core component of the disease process of schizophrenia. In addition, the Center provides 1) a rich environment for training and career development in which individuals can become involved in studies that bring the methods and knowledge base of basic neuroscience to address critical questions in clinical schizophrenia research, and 2) a mechanism for disseminating the importance of, and the knowledge gained from, translational studies of schizophrenia to the broader scientific and lay communities.

这个孔戴神经科学中心精神障碍（CCNMD）提供了高度互动的科学 整合来自多个研究人员的基本和临床研究活动的环境 匹兹堡大学医学与艺术与科学学校以及邻近的卡内基·梅隆（Carnegie Mellon） 大学。总体而言，CCNMD代表了跨越分子，系统， 认知，计算和临床神经科学，提供了测试的补充方法 中心假设是GABA神经元亚群中分子改变的独特模式 （病理）引起了皮质网络振荡（病理生理学）的保守干扰 基于精神分裂症的核心信息处理缺陷（临床综合征）。提议的5 由行政，临床服务和诊断以及统计和数据支持的项目 管理核心，检查1）精神分裂症的分子异常在不同的皮质子集中 GABA神经元被认为会产生振荡活动（项目1-刘易斯）； 2）集成计算， 电生理和解剖方法，以确定细胞类型特异性之间的关系 皮质GABA神经传递和体外振荡（项目2-ErmentRout）； 3）GABA的作用 在非人类灵长类动物中点击的任务引起的皮质振荡中的神经传递 精神分裂症中改变的信息处理领域（项目3-Olson）； 4）特定类型的 精神分裂症中的信息处理障碍与改变的激活有关，并受到损害 网络振荡，某些皮质区域（项目4-Phillips）； 5）新宠物的发展 研究体内人体皮质GABA神经元功能的成像工具（Project 5-Mathis）。这 这些项目的协同作用和双向互动有助于转化方法 精神分裂症研究指导鉴定基于病理生理学的新治疗靶标 干预措施和开发可用于监测功效的病理生理学的生物标志物 这样的干预措施。因此，拟议的中心是一种旨在测试机械的多学科努力 假设是为了提高我们对疾病过程中核心组成部分的理解 精神分裂症。此外，该中心提供1）培训和职业发展的丰富环境 哪些人可以参与带来基本方法和知识基础的研究 神经科学解决临床精神分裂症研究中的关键问题，以及2）一种机制 传播精神分裂症转化研究的重要性和知识 更广泛的科学和外行社区。