Neurobiological Mechanisms of Drug Reinforcement

药物强化的神经生物学机制

基本信息

批准号：
7491590
负责人：
JAMES E SMITH
金额：
$ 0.91万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-02-01 至 2008-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7491590
关键词：
Acetylcholine Address Affect Agonist Alkylating Agents Alkylation Animal Experiments Animals Area Attenuated Award Behavioral Behavioral Model Biological Brain Brain region Breeding Cell Nucleus Cells Chemosensitization Choline O-Acetyltransferase Cholinergic Agents Cholinergic Receptors Circadian Rhythms Cocaine Collaborations Complex Condition Data Development Diagonal Band of Broca Dopamine Dopamine D2 Receptor Dose Drug abuse Drug usage Elevation Enkephalin, Ala(2)-MePhe(4)-Gly(5)-Enkephalin, D-Penicillamine (2,5)-Enkephalins Experimental Designs Extracellular Fluid Fire - disasters Food Funding GABA Antagonists GABA Receptor Gene Expression Globus Pallidus Glutamates Goals Harvest Heroin Hippocampus (Brain)Human Immunoglobulin G Immunotoxins Individual Injection of therapeutic agent Institution Intake International Interneurons Intravenous Investigation Japan Justice Kainic Acid Receptors Laboratories Left Lesion Limb structure Measurement Medial Mediating Methodology Methods Mexico Microdialysis Modeling Modification Mosses Mouse Strains Mus Muscarinic Acetylcholine Receptor Muscarinic Agonists Muscarinics NGFR Protein National Institute of Drug Abuse Nerve Endings Neurobiology Neurons Neurotoxins Neurotransmitters Nicotinic Receptors Nucleus Accumbens Nucleus Basalis Magnocellularis Numbers Octanes Opiates Opioid Opioid Receptor Output Oxidopamine Oxotremorine Pattern Peptides Pharmaceutical Preparations Polymerase Chain Reaction Population Principal Investigator Procedures Process Progress Reports Prosencephalon Proteins Proteomics Psychological reinforcement Purpose Rate Rattus Receptor Activation Receptor Inhibition Relative (related person)Research Research Personnel Research Project Grants Research Scientist Award Reverse Transcriptase Polymerase Chain Reaction Rodent Rodent Model Role Russia Schedule Scientist Self Administration Self-Administered Series Site Slice Specificity Structure Students Substance abuse problem System Techniques Testing Time Tissues Training Transgenic Mice Transgenic Organisms Universities Ventral Tegmental Area Western Blotting basal forebrain base career chlornaltrexamine cholinergic cholinergic neuron deltorphin design drug maintenance drug reinforcement extracellular follow-up forest functional genomics gamma-Aminobutyric Acid high school human CHRM4 protein in vivo indexing interest leucyl-alanine medical schools methylcarbachol mouse model naltrindole 5&apos -isothiocyanate nerve supply neurobiological mechanism neuronal cell body neurotransmission octane oxazolidine programs receptor research and development research study response transcriptional coactivator p75 treatment effect

项目摘要

DESCRIPTION (provided by applicant): This award will continue to permit the candidate to concentrate on individual and collaborative research efforts on substance abuse. During the next five years the candidate will be significantly involved in studies of the neurobiological mechanisms of the self-administration of cocaine, heroin and cocaine/heroin combinations that include investigation of the role of cholinergic systems in cocaine self-administration (DA 03628) and investigation of the mechanisms underlying the ability of heroin to potentiate the reinforcing effects of cocaine demonstrated in this last funding period. This includes identification of the opioid receptor subtypes and their loci responsible for this potentiation (DA12498) and the use of a discrete trial procedure for drug presentation that may provide a rodent model for the transition from drug use to abuse (NIDA funded Center- DA06634 Project 3). During this last funding period international collaborations were initiated that included interactions with scientists in Russia and Mexico with common interests in the neurobiology of drug abuse which will continue and expand in scope. In addition, the candidate will continue to participate in the training of high school, undergraduate and graduate students in the responsible conduct of research. During this next funding period the major career development effort for the candidate will be to acquire expertise in functional genomics and proteomics which are expected to be integrated into his research program. Research, research development and research administration are expected to consume a significant portion of the candidate's efforts. This Senior Research Scientist award will continue to permit the candidate to broaden his and the institution's drug abuse research efforts to further enhance the impact of the drug abuse research program at Wake Forest University School of Medicine.

描述（由申请人提供）：该奖项将继续允许候选人专注于药物滥用方面的个人和合作研究工作。在接下来的五年中，候选人将大力参与可卡因、海洛因和可卡因/海洛因组合自我给药的神经生物学机制的研究，包括研究胆碱能系统在可卡因自我给药中的作用（DA 03628）和对最后一个资助期间所展示的海洛因增强可卡因增强作用的能力的机制进行了调查。这包括鉴定阿片受体亚型及其负责这种增强作用的位点（DA12498），以及使用离散试验程序进行药物呈现，这可能为从药物使用到滥用的过渡提供啮齿动物模型（NIDA 资助的中心 - DA06634 项目） 3）。在最后一个资助期间，启动了国际合作，其中包括与俄罗斯和墨西哥对药物滥用神经生物学有共同兴趣的科学家的互动，这种合作将继续下去并扩大范围。此外，候选人将继续参加高中、本科生和研究生的培训，以负责任的方式进行研究。在下一个资助期内，候选人的主要职业发展努力将是获得功能基因组学和蛋白质组学方面的专业知识，这些专业知识预计将纳入他的研究计划中。研究、研究开发和研究管理预计将消耗候选人的大部分精力。该高级研究科学家奖将继续允许候选人扩大他和该机构的药物滥用研究工作，以进一步增强维克森林大学医学院药物滥用研究项目的影响。