STATISTICAL GENETICS AND TREATMENT ANALYSIS

统计遗传学和治疗分析

基本信息

批准号：
8120342
负责人：
ROBERT R FREEDMAN
金额：
$ 9.52万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8120342
关键词：
Accounting Admixture Affect Alleles Antipsychotic Agents Area Biometry Brain Candidate Disease Gene Clinical Research Clinical Trials Collaborations Collection Colorado Commit Communication Complex Consult Data Data Analyses Development Doctor of Philosophy Ensure Epidemiology Faculty Family Frequencies Gene Expression Gene Frequency Genes Genetic Genetic Polymorphism Genetic Variation Genome Genotype Haplotypes Heterogeneity Human Human Resources Impaired cognition Individual Infant Development Instruction Insulin Resistance Intervention Joints Linear Regressions Logistic Regressions Measurement Methodology Methods Modeling Molecular Genetics Mus NRG1 gene Nature Neuregulins Nicotine Nicotinic Receptors Outcome Paper Persons Pharmaceutical Preparations Phase II Clinical Trials Phenotype Plasma Predisposition Preparation Principal Investigator Psychotic Disorders Recording of previous events Regulation Reporting Research Design Research Personnel Sampling Schizophrenia Series Services Statistical Methods Students Subjects Selections Symptoms TNFRSF5 gene Techniques Testing Therapy Clinical Trials Time Universities Variant Vertebrates Weight Work base case control comparison group design experience follow-up gene interaction genetic association genetic epidemiology genetic variant graduate student human subject improved interest member new therapeutic target novel therapeutics prevent proband professor programs promoter research study sensory gating statistics tool trait

项目摘要

The Statistical Genetics and Treatment Analysis Core is designed to provide support in study design, data analysis, and interpretation. All Core members participate in preparation of reports, presentations, and manuscnpts. In addition. Core members will continue their efforts to develop new statistical approaches that will improve the analytic techniques available to Center investigators. Specific developments include methods to increase the power for association analysis in an area with a known linkage and methods to assign a false discovery rate to multiple gene expression measurements in a microarray experiment. Core B provides services to all five Projects. RELEVANCE (See instructions): New therapeutic strategies for schizophrenia are needed to improve cognitive dysfunction and negative symptoms and to prevent the development of psychosis. The Center investigates a nicotinic acetylcholine receptor as a new therapeutic target. Investigational results are used to design a new drug treatment for schizophrenia and a preventative nutnent intervention dunng infant development, both of which activate this rpr.pntr>r

统计遗传学和治疗分析核心旨在为研究设计提供支持分析和解释。所有核心成员都参与准备报告，演示和 manuscnpts。此外。核心成员将继续努力开发新的统计方法将改善可用于中心研究人员的分析技术。具体发展包括在具有已知联系和方法的区域中增加关联分析功能的方法在微阵列实验中为多个基因表达测量分配错误的发现率。核心B为所有五个项目提供服务。相关性（请参阅说明）：需要针对精神分裂症的新治疗策略来改善认知功能障碍和阴性症状并防止精神病的发展。该中心研究了烟碱乙酰胆碱受体作为新的治疗靶点。研究结果用于设计一种新药物治疗精神分裂症和预防性的干预措施厌倦了婴儿的发育，这两者都激活了这一点 rpr.pntr> r