Response variability in primary auditory cortex of behaving squirrel monkey

行为松鼠猴初级听觉皮层的反应变异性

• 批准号: 8141348
• 负责人: STEPHEN G LISBERGER
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141348
• 关键词: Address; Affect; Afferent Neurons; Animals; Attention; Auditory; Auditory area; Behavior; Behavioral; Birds; Cell physiology; Code; Detection; Discrimination; Electrodes; Elements; Exhibits; Frequencies; Generations; Goals; Incidence; Learning; Link; Maps; Measurement; Measures; Methods; Modality; Monkeys; Motor; Nature; Neurons; Operant Conditioning; Outcome; Perceptual learning; Performance; Positioning Attribute; Process; Psychophysiology; Rattus; Regimen; Research; Rodent; Role; Saimiri; Sensory; Stimulus; Stratum Granulosum; System; Task Performances; Testing; Training; Variant; awake; base; improved; interest; operation; programs; receptive field; relating to nervous system; research study; response; sensorimotor system; sensory stimulus; sound

The auditory cortex exhibits a broad range of response modes spanning from phasic, single spike or binary responses to tonic, multi-spike, sustained random firing sequences per stimulus. The goal of this project is to determine the character of response variability of different types of auditory cortical neurons in the awaken squirrel monkey. This will allow us to assess the potential role and influence of variability on neuronal encoding, and its impact on behavioral performance and to compare the results to other response modalities. To achieve this, it is necessary to obtain simultaneous estimates of neural and behavioral performance in the awaken animal. Response variability will be assessed under three conditions, in the passive listening animal to serve as a baseline, in the animal actively involved in a behavioral sound discrimination task to assess attention effects, and in animals that are highly trained to assess the effects of learning on the expression of response variability. In conjunction with the other projects, these studies will contribute to establishing general rules, across sensory and motor systems, of the nature and role of response variability in the generation of behavior.

听觉皮层表现出跨越阶段，单峰或二进制的各种响应模式 每个刺激的补品，多尖峰，持续的随机射击序列的响应。这个项目的目标是 确定觉醒中不同类型的听觉皮质神经元的响应变异性的特征 松鼠猴。这将使我们能够评估变异性对神经元的潜在作用和影响 编码及其对行为绩效的影响，并将结果与​​其他响应进行比较 方式。为了实现这一目标，有必要同时估计神经和行为 觉醒动物的表现。响应可变性将在三个条件下评估 被动听力动物作为基准，在积极参与行为声音的动物中 评估注意力效应的歧视任务，以及经过高度训练的动物来评估 学习响应变异性的表达。结合其他项目，这些研究将 有助于建立跨感官和运动系统，性质和作用的一般规则 行为产生的响应差异。