CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT

棕色脂肪交感神经活动的中枢调节

• 批准号: 8173282
• 负责人: SHAUN F MORRISON
• 金额: $ 12.37万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173282
• 关键词: Adipose tissue; Body Weight; Brown Fat; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diabetes Mellitus; Disease; Energy Intake; Energy Metabolism; Equilibrium; Funding; Glucose; Grant; Homeostasis; Hypertension; Hypothalamic structure; Institution; Insulin; Leptin; Maintenance; Metabolic; Neural Pathways; Neurons; Obesity; Preoptic Areas; Regulation; Research; Research Personnel; Resources; Role; Serotonin; Signal Pathway; Signal Transduction; Source; Spinal; Testing; Therapeutic; Thermogenesis; United States National Institutes of Health; body system; design; prevent; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Balancing energy expenditure with energy intake, metabolic requirements and energy storage is critical for maintenance of body weight, for sustained responsiveness to metabolic signals such as glucose, insulin and leptin and for homeostatic regulation of many body systems. Our experiments are defining and testing the hypothesis that energy expenditure in BAT is a potential sink for the consumption of surplus energy intake to prevent excess energy storage in white adipose tissue. Defining energy afferent signaling pathways, as well as those efferent neural pathways controlling the BAT energy expenditure effector will contribute to our understanding of the regulation of body weight and of energy substrate availability and to the design of therapeutic strategies to control disturbances in body energy homeostasis that result in diseases such as obesity, diabetes and hypertension. Recent findings include the identification of distinct projections from the preoptic area to the dorsomedial hypothalamus and to the raphe pallidus, the characterization of an inhibitory influence on BAT from paraventricular hypothalamic neurons and the determination of a prominent role for spinal serotonin release in the cooling-evoked increase in BAT thermogenesis and energy expenditure.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 平衡能量消耗与能量摄入，代谢需求和能量储存对于维持体重至关重要，对于葡萄糖，胰岛素和瘦素等代谢信号的持续响应以及许多身体系统的稳态调节。我们的实验定义了并检验的假设，即BAT中的能量消耗是消耗剩余能量摄入以防止在白色脂肪组织中储存过多的储能。定义能源传入的信号通路，以及控制BAT能量消耗效应器的那些传出的神经途径将有助于我们理解体重的调节，能量底物的可用性以及治疗策略的设计，以控制体内能量的障碍，从而导致疾病，例如肥胖，糖尿病和糖尿病，糖尿病和高血压。 最近的发现包括鉴定从原骨前区到背部下丘脑和raphe pallidus的不同预测，抑制性下丘脑神经元对蝙蝠的抑制作用的表征以及确定脊柱蛋白在冷却诱发的蝙蝠热发生和能量中的脊柱脊髓蛋白释放的重要作用。