CENTRAL SYMPATHETIC REGULATION OF THERMOGENESIS IN FEVER

发烧时中枢交感神经对产热的调节

• 批准号: 8173281
• 负责人: SHAUN F MORRISON
• 金额: $ 12.37万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173281
• 关键词: Affect; Amphetamine Abuse; Anesthesia procedures; Body Temperature; Computer Retrieval of Information on Scientific Projects Database; Energy Metabolism; Fever; Funding; Grant; Hot flushes; Hypothalamic structure; Institution; Life; Malignant Neoplasms; Mediating; Meningitis; Menopause; Neurons; Operative Surgical Procedures; Pharmaceutical Preparations; Preoptic Areas; Pyrogens; Regulation; Research; Research Personnel; Resources; Role; Sepsis; Septic Toxemia; Serotonin; Source; Spinal; Therapeutic; Thermogenesis; United States National Institutes of Health; base; clinically significant; combat; induced hypothermia; neuromechanism; paraventricular nucleus; prostate surgery

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding of the central neural mechanisms mediating fever and cold defense will be relevant for developing therapeutic approaches to combat life-threatening excessive fevers (as during sepsis, toxemia, meningitis, some cancers) and to the management of the effects of thermal dysregulation that occurs during such clinically significant conditions as the abuse of amphetamine-based drugs, the hot flashes accompanying menopause and prostate surgery or the hypothermia induced during surgical anesthesia. The aims of this project are to elucidate the CNS circuits that regulate body temperature and how they are affected by pyrogens. Recent findings include the identification of distinct projections from the fever-inhibited neurons in the preoptic area to the BAT sympathoexcitatory regions of the dorsomedial hypothalamus and to the raphe pallidus, the demonstration that the principal effect of neuronal activation in the paraventricular hypothalamic nucleus is an inhibition of BAT thermogenesis and the elucidation of a prominent disinhibitory role for spinal serotonin release in the cooling-evoked increase in BAT thermogenesis and energy expenditure.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 了解介导的发烧和冷防御的中枢神经机制的理解与开发治疗方法，以打击生命的过度发烧（如败血症，毒血症，毒素，脑膜炎，某些癌症），以及在伴随着伴有秋葵胺的疾病伴随着伴随着炎症性疾病的情况下发生的临床严重状况，伴随着炎症性的药物和腐蚀性疾病的效果的影响，伴随着炎症性的药物和腐蚀性疾病。手术麻醉期间诱导的体温过低。该项目的目的是阐明调节体温的中枢神经系统电路以及如何受到金刚元的影响。 Recent findings include the identification of distinct projections from the fever-inhibited neurons in the preoptic area to the BAT sympathoexcitatory regions of the dorsomedial hypothalamus and to the raphe pallidus, the demonstration that the principal effect of neuronal activation in the paraventricular hypothalamic nucleus is an inhibition of BAT thermogenesis and the elucidation of a prominent disinhibitory role for脊柱血清素在冷却引起的蝙蝠热发生和能量消耗的增加中释放。