UNDERSTANDING NEURODEVELOPMENT IN MACAQUES WITH DIFFERENT REARING EXPERIENCES

了解不同饲养经历的猕猴的神经发育

• 批准号: 8172398
• 负责人: MAR M SANCHEZ
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172398
• 关键词: Adolescence; Adolescent; Affect; Age; Amygdaloid structure; Animals; Brain; Brain region; Caring; Computer Retrieval of Information on Scientific Projects Database; Development; Diffusion Magnetic Resonance Imaging; Employee Strikes; Funding; Grant; Gray unit of radiation dose; Hippocampus (Brain); Hydrocortisone; Infant; Institution; Life; Life Stress; Long-Term Effects; Macaca; Macaca mulatta; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modeling; Parietal; Period Analysis; Prefrontal Cortex; Research; Research Personnel; Resources; Source; Stress; Structure; Technology; United States National Institutes of Health; Visual Cortex; brain volume; experience; in vivo; infancy; interest; myelination; neurodevelopment; neuroimaging; nonhuman primate; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We used a naturalistic nonhuman primate model of early life stress (ELS) consisting of poor maternal care to characterize the long-term impact on neurodevelopment using in vivo neuroimaging technology, using structural MRI, diffusion tensor imaging (DTI) and MR spectroscopy. In order to understand the effects on brain development, we had to examine normative brain development during the rhesus monkey infant period, and analyzed potential associations with socioemotional maturation. Our findings revealed dramatic brain developmental changes during infancy, particularly fast and striking between 2 weeks and 3 months, including increased brain volume, deepening of sulci and intense rates of myelination. We found that at 2 weeks some cortical regions, such as the prefrontal cortex, were not yet myelinated. These findings underscored the high vulnerability of the brain, particularly prefrontal circuits with protracted development, to stress experienced at these early ages, which could result in alterations in normal brain developmental trajectories. We demonstrated that ELS indeed affects brain development using a model of poor maternal care. For example, long-term alterations in brain myelinated tracts were detected during adolescence, particularly in prefrontal, temporal, parietal and visual cortices. We found a significant decrease in amygdala volume of animals with ELS, despite no differences in overall brain, gray or white matter volumes, or in other regions of interest (e.g. hippocampus). Interestingly, the amygdala volume negatively correlated with basal cortisol at month 1, when animals experienced the highest levels of stress as infants. Altogether, our findings suggest the ELS has long-term effects on the structure and connectivity of limbic brain regions of nonhuman primates. The reduced amygdala volume detected during the adolescent period seems related to the stress-induced elevations in cortisol early in life.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们使用结构MRI，扩散量张量成像（DTI）和MR Spectroscopicy使用了由不良母体护理组成的自然主义非人类生命应力（EL）（ELS）（ELS）（ELS）来表征对神经发育的长期影响。 为了了解对大脑发育的影响，我们必须检查恒河猴婴儿时期规范性的大脑发育，并分析了与社会情感成熟的潜在关联。我们的发现表明，婴儿期的大脑发育变化发生了巨大的变化，尤其是在2周至3个月之间的快速和惊人的变化，包括大脑体积增加，硫酸的加深和强烈的髓鞘率。我们发现，在2周时，一些皮质区域（例如前额叶皮层）尚未髓鞘。这些发现强调了大脑的高脆弱性，尤其是前额叶发育的前额叶回路，在这些早期时代所经历的压力可能会导致正常脑发育轨迹的改变。 我们证明了EL确实使用不良的孕产妇护理模型影响大脑发育。例如，在青春期，尤其是在额叶，颞叶，顶叶和视觉皮层中，检测到脑髓倾斜的长期改变。我们发现，尽管整体大脑，灰色或白质体积或其他感兴趣的区域没有差异（例如，海马），但杏仁核的杏仁核体积显着减少。有趣的是，杏仁核体积与第1个月的基底皮质醇负相关，当时动物作为婴儿的压力最高。 总的来说，我们的发现表明ELS对非人类灵长类动物的边缘大脑区域的结构和连通性具有长期影响。在青少年时期检测到的杏仁核体积减少似乎与生命早期皮质醇升高的升高有关。