MATERNAL HIGH FAT DIET PROGRAMS VASCULAR PATHOLOGY IN INFANTS

母亲高脂肪饮食计划 婴儿血管病理学

• 批准号: 8173252
• 负责人: KEVIN L GROVE
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173252
• 关键词: Animals; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Child; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Diet; Fatty acid glycerol esters; Fetus; Funding; Grant; Human; Hyperlipidemia; Infant; Institution; Intake; Metabolic; Metabolic Diseases; Modeling; Monkeys; Mothers; Neonatal; Obesity; Pathology; Play; Process; Reporting; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; early onset; fetal; high risk; hypercholesterolemia; nonhuman primate; offspring; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence indicates that an abnormal maternal metabolic status, such as diabetes, exerts deleterious effects on the cardiovascular system of the fetus that may last for a lifetime. Arthrosclerosis is the process responsible for most cardiovascular disease. Recently it was reported that children born to obese mothers had a high risk of early development of fatty streaks in major vessels (an early sign of arthrosclerosis); however, it is unknown what maternal factors may be contributing to the early signs of cardiovascular disease in these children. Maternal obesity, diabetes, fat intake, hypercholesterolemia and hyperlipidemia are some factors that could play a critical pathophysiological role in the development of arthrosclerosis in children. We have developed a nonhuman primate model maternal diet induced obesity/diabetes, where monkeys are maintained on a high fat diet (HFD) for 2-4 years. These animals develop the full compliment of metabolic disease as humans and are thus an excellent model to begin to investigate the contributing factors to early onset cardiovascular disease. The purpose of this project is to begin to determine if there are signs of cardiovascular complications in fetal and neonatal offspring of HFD animals. Furthermore, these studies will provide the preliminary data to develop a hypothesis about what maternal factors may be contributing to the cardiovascular disease in the offspring.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 有证据表明，异常的母亲代谢状态（例如糖尿病）会对胎儿的心血管系统产生有害影响，这种影响可能会持续一生。关节硬化是导致大多数心血管疾病的过程。最近有报道称，肥胖母亲所生的孩子在主要血管中早期出现脂肪纹（关节硬化的早期征兆）的风险很高；然而，尚不清楚哪些母亲因素可能导致这些儿童出现心血管疾病的早期症状。母亲肥胖、糖尿病、脂肪摄入、高胆固醇血症和高脂血症是可能在儿童关节硬化的发展中发挥关键病理生理作用的一些因素。我们开发了一种非人类灵长类动物模型，母体饮食诱发肥胖/糖尿病，其中猴子维持高脂肪饮食 (HFD) 2-4 年。这些动物与人类一样发展出代谢疾病的全面补充，因此是开始研究早发性心血管疾病的促成因素的绝佳模型。该项目的目的是开始确定 HFD 动物的胎儿和新生儿后代是否存在心血管并发症的迹象。此外，这些研究将提供初步数据，以提出关于哪些母亲因素可能导致后代心血管疾病的假设。